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Treatment and Prognosis

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Precision Molecular Pathology of Hodgkin Lymphoma

Part of the book series: Molecular Pathology Library ((MPLB))

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Abstract

This chapter will outline the current state of the art of the treatment for Hodgkin lymphoma (HL) with a focus on prognostic factors and risk assessment tools. For newly diagnosed patients with HL, the goal of treatment should be a therapeutic strategy which maximizes the possibility of cure while minimizing the risk of long-term toxicity. Here we discuss clinical prognostic scoring systems, positron emission tomography (PET), and biomarkers, currently used or under investigation, as guide to therapeutic decision making. We further discuss the current standards for first-line therapy of HL, with a special focus on risk-adapted approaches. For relapsed patients we discuss standard treatments and highlight newly approved and promising immunotherapy. Finally we discuss treatment standards for special classes of patients: the elderly, pediatric patients, and patients with lymphocyte predominant (LP) HL. This is an exciting time, as our knowledge of HL biology deepens, evolving risk assessment tools model new treatment strategies, and new therapies are approved, leading the way to patient tailored approaches.

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Authors and Affiliations

  1. Center for Lymphoid Malignancies, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 51 West 51st Street, 2nd Floor, New York, NY, 10019, USA

    Francesca Montanari M.D.

  2. NYU Perlmutter Cancer Center, NYU Cancer Center, 240 East 38th Street, 19th Floor, New York, NY, 10016, USA

    Catherine S. M. Diefenbach M.D.

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  1. Francesca Montanari M.D.
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  2. Catherine S. M. Diefenbach M.D.
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Correspondence to Catherine S. M. Diefenbach M.D. .

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  1. Department of Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    S. David Hudnall

  2. Universität Duisburg-Essen, Institute for Cell Biology, Essen, Nordrhein-Westfalen, Germany

    Ralf Küppers

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Montanari, F., Diefenbach, C.S.M. (2018). Treatment and Prognosis. In: Hudnall, S., Küppers, R. (eds) Precision Molecular Pathology of Hodgkin Lymphoma . Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-68094-1_9

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  • DOI: https://doi.org/10.1007/978-3-319-68094-1_9

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