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Application of LIPUS to the Temporomandibular Joint

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Therapeutic Ultrasound in Dentistry

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Abstract

The most common joint pathology affecting the temporomandibular joint (TMJ) is degenerative joint disease, also known as osteoarthritis (OA). TMJ-OA is characterized by mandibular condylar cartilage degradation due to mechanical overloading. Rheumatoid arthritis (RA) is also a systemic, chronic inflammatory disease of the TMJ with cartilage destruction and infiltration of inflammatory cells into synovial tissue. Since the fibrocartilage covering both the TMJ condyle and articular eminence is avascular, these fibrocartilage cells have limited ability to self-repair. Therefore, once the breakdown in the joint starts, TMJ-OA and TMJ-RA can be crippling, leading to a variety of morphological and functional deformities. From in vitro and in vivo studies, low-intensity pulsed ultrasound (LIPUS) downregulates COX-2 and PGE2 expression, upregulates HAS2 and HAS3 expression, and suppresses the proliferation and growth in IL-1β-stimulated synovial membrane cells and reduces COX-2 expression and synovial hyperplasia in RA joints. These results are indicative of distinct anabolic effect of LIPUS application that enhances the TMJ metabolism and regeneration. In conclusion, LIPUS may be a medical treatment option for degenerative joint diseases such as RA and OA.

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Authors and Affiliations

  1. Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    Eiji Tanaka & Minami Sato

  2. Department of Orthodontics, King Abdulaziz University, Jeddah, Saudi Arabia

    Eiji Tanaka

  3. Kawakami Orthodontic Clinic, Takamatsu, Japan

    Tatsuya Nakamura

  4. Department of Dentistry, University of Alberta, Edmonton, Canada

    Harmanpreet Kaur

  5. Dentistry/Orthodontics and Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

    Tarek El-Bialy

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  1. Eiji Tanaka
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  2. Tatsuya Nakamura
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  3. Minami Sato
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  4. Harmanpreet Kaur
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  5. Tarek El-Bialy
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Correspondence to Eiji Tanaka .

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Editors and Affiliations

  1. Dentistry/Orthodontics and Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

    Tarek El-Bialy

  2. Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    Eiji Tanaka

  3. Technion—Faculty of Medicine Oral Biology Research Laboratory, Rambam Health Care Campus, Haifa, Israel

    Dror Aizenbud

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Tanaka, E., Nakamura, T., Sato, M., Kaur, H., El-Bialy, T. (2018). Application of LIPUS to the Temporomandibular Joint. In: El-Bialy, T., Tanaka, E., Aizenbud, D. (eds) Therapeutic Ultrasound in Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-319-66323-4_6

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  • DOI: https://doi.org/10.1007/978-3-319-66323-4_6

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