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Inhibition of Bacterial Quorum Sensing Systems by Metal Nanoparticles

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Metal Nanoparticles in Pharma

Abstract

Quorum sensing (QS ) is a commonly used way for intercellular communication utilizing small, self-generated signal molecules called autoinducers . QS-controlled genes can constitute as much as 10% of bacterial genome. This system controls a variety of bacterial physiological traits, including biofilm formation and pathogenesis. QS signaling pathways are well described in several species including Pseudomonas aeruginosa and Staphylococcus aureus . The inhibition of QS, called quorum quenching (QQ ), can be a potential and promising strategy to combat bacterial infections. Nanoparticles (NPs ) are considered to be potential QS inhibitors which was proved mainly by in vitro experiments. The QQ potential was proved for silver nanoparticles (AgNPs ) which was demonstrated by their ability to inhibit bacterial biofilms. Antibiofilm activity of gold nanoparticles (AuNPs ), zinc oxide nanoparticles (ZnONPs ), copper nanoparticles (CuNPs ), and platinum nanoparticles (PtNPs ) was also shown. As an antibacterial potential of metal NPs is well documented, the ability to inhibit QS additionally argues toward their future usage as an alternative of antibiotics . Moreover, the development of bacterial resistance to NPs was not yet well documented.

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Abbreviations

AgNPs :

Silver nanoparticles

Agr :

Accessory gene regulator

AIPs :

Autoinducing peptides

AuNPs :

Gold nanoparticles

CF :

Cystic fibrosis

CuNPs :

Copper nanoparticles

HSLs :

Homoserine lactones

MRSA:

Methicillin-resistant S. aureus

PIA:

Polysaccharide intercellular antigen

PQS :

Pseudomonas quorum sensing

PtNPs :

Platinum nanoparticles

QQ :

Quorum quenching

QS :

Quorum sensing

RIP:

RNAIII inhibiting peptide

ROS :

Reactive oxygen species

ZnONPs:

Zinc oxide nanoparticles

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Authors and Affiliations

  1. Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland

    Krystyna I. Wolska, Anna M. Grudniak & Katarzyna Markowska

Authors
  1. Krystyna I. Wolska
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  2. Anna M. Grudniak
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  3. Katarzyna Markowska
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Correspondence to Krystyna I. Wolska .

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Editors and Affiliations

  1. Nanobiotechnology laboratory, Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India

    Mahendra Rai, Ph.D

  2. Institute of Pharmacy, Department Pharmaceutics, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin, Germany

    Ranjita Shegokar, Ph.D

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Wolska, K.I., Grudniak, A.M., Markowska, K. (2017). Inhibition of Bacterial Quorum Sensing Systems by Metal Nanoparticles. In: Rai, Ph.D, M., Shegokar, Ph.D, R. (eds) Metal Nanoparticles in Pharma. Springer, Cham. https://doi.org/10.1007/978-3-319-63790-7_7

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