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Metabotropic Glutamate Receptors in Cancer

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mGLU Receptors

Part of the book series: The Receptors ((REC,volume 31))

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Abstract

Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers. More recently, aberrant glutamate signaling has been shown to participate in the transformation and maintenance of various cancer types, including glioma, melanoma skin cancer, breast cancer, and prostate cancer, indicating that genes encoding mGluRs, GRMs, can function as oncogenes. Here, we provide a review on the interactions of mGluRs and their ligand, glutamate, in processes that promote the growth of tumors of neuronal and non-neuronal origins. Further, we discuss the evolution of riluzole, a glutamate release inhibitor approved for amyotrophic lateral sclerosis (ALS), but now fashioned as an mGluR1 inhibitor for melanoma therapy and as a radiosensitizer for tumors that have metastasized to the brain. With the success of riluzole, it is not farfetched to believe that other drugs that may act directly or indirectly on other mGluRs can be beneficial for multiple applications.

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Authors and Affiliations

  1. Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, 08854, USA

    Lumeng J. Yu, Brian A. Wall, Janet Wangari-Talbot & Suzie Chen Ph.D.

  2. Global Product Safety, Colgate-Palmolive Company, Piscataway, NJ, 08854, USA

    Brian A. Wall

  3. The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA

    Suzie Chen Ph.D.

Authors
  1. Lumeng J. Yu
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  2. Brian A. Wall
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  3. Janet Wangari-Talbot
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  4. Suzie Chen Ph.D.
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Corresponding author

Correspondence to Suzie Chen Ph.D. .

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Editors and Affiliations

  1. Neuropharmacology Unit I.N.M. Neuromed, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Richard Teke Ngomba

  2. Department of Physiology and Biochemistry, University of Malta, Malta, Italy

    Giuseppe Di Giovanni

  3. Neuropharmacology Unit, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Giuseppe Battaglia

  4. Dipartimento di Fisiologia Umana, Università di Roma, Roma, Italy

    Ferdinando Nicoletti

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Yu, L.J., Wall, B.A., Wangari-Talbot, J., Chen, S. (2017). Metabotropic Glutamate Receptors in Cancer. In: Ngomba, R., Di Giovanni, G., Battaglia, G., Nicoletti, F. (eds) mGLU Receptors. The Receptors, vol 31. Humana Press, Cham. https://doi.org/10.1007/978-3-319-56170-7_9

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