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Age-Related Differences in the Human Hippocampus: Behavioral, Structural and Functional Measures

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The Hippocampus from Cells to Systems

Abstract

In this chapter we review the behavioral and neuroimaging literature on age-related differences in hippocampal function. Although it is well known that older adults have reduced relational memory, which depends on the hippocampus, and that hippocampal volume is reduced in older adults, activity in this region is not uniformly lower in older than younger adults during encoding and retrieval tasks. Nevertheless, when the functional neuroimaging evidence is examined in light of current theories of the pattern separation and completion processes carried out by the hippocampus, both processes appear to be altered in older age. We conclude with some suggestions for future work in this field.

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Notes

  1. 1.

    Some authors (e.g., Naveh-Benjamin 2000) have used the term “associative memory” in their descriptions of these age-related memory deficits. As has been done in the past (e.g., Ryan et al. 2007), we use the term “relational memory” here. For further explanation about differences in the interpretation of these terms, readers can consult Moses et al. (2008b).

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Authors and Affiliations

  1. Rotman Research Institute at Baycrest, University of Toronto, Toronto, ON, Canada

    Cheryl L. Grady & Jennifer D. Ryan

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  1. Cheryl L. Grady
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  2. Jennifer D. Ryan
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Correspondence to Cheryl L. Grady .

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Editors and Affiliations

  1. Department of Psychology, University of Wisconsin - Milwaukee, Milwaukee, Wisconsin, USA

    Deborah E. Hannula

  2. Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Melissa C. Duff

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Grady, C.L., Ryan, J.D. (2017). Age-Related Differences in the Human Hippocampus: Behavioral, Structural and Functional Measures. In: Hannula, D., Duff, M. (eds) The Hippocampus from Cells to Systems. Springer, Cham. https://doi.org/10.1007/978-3-319-50406-3_7

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