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Oral Cancer and Chewing Habits

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Development of Oral Cancer

Abstract

Oral cancer (OC) is highly prevalent worldwide with significant mortality and morbidity. An individual inflicted by this disease may experience devastating consequences such as disfiguring of the face after surgery and possibly an inability to take food through the oral cavity and disruption of normal speech. Smoking, alternate chewing habits, and alcohol are major risk factors. Other factors include high-risk HPV, diet, oral hygiene, and socioeconomic status. In the West, cigarette smoking and alcohol are the key risk factors. Betel quid (areca nut; major component) and its related products are chewed commonly in many parts of the world, being most prevalent in the Asian continent. More than 600 million people are known to chew betel quid worldwide. Unlike tobacco smoking, betel quid is culturally well accepted and openly consumed by all strata of society. Other commercially distributed products include gutka and naswar which almost always contain a significant component of chewable tobacco and are easily available and consumed widely by both adults and children. On the face of such high burden of OC, there is an urgent need to implement control on these products. Screening methods may also be implemented for high-risk populations, keeping in mind the cost and resources involved.

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References

  1. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132(5):1133–45. doi:10.1002/ijc.27711. Epub 2012 Jul 26

    Article  CAS  PubMed  Google Scholar 

  2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86. doi:10.1002/ijc.29210. Epub 2014 Oct 9

    Article  CAS  PubMed  Google Scholar 

  3. Krishna Rao SV, Mejia G, Roberts-Thomson K, Logan R. Epidemiology of oral cancer in Asia in the past decade – an update (2000–2012). Asian Pac J Cancer Prev. 2013;14(10):5567–77.

    Article  PubMed  Google Scholar 

  4. IARC. IARC monographs on the evaluation of carcinogenic risks to humans, volume 85: Betel quid and areca nut derived nitrosamines. Lyon: IARC; 2004.

    Google Scholar 

  5. Howlader N, Ries LA, Mariotto AB, Reichman ME, Ruhl J, Cronin KA. Improved estimates of cancer-specific survival rates from population-based data. J Natl Cancer Inst. 2010;102(20):1584–98. doi:10.1093/jnci/djq366. Epub 2010 Oct 11

    Article  PubMed  PubMed Central  Google Scholar 

  6. Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R, EUROCARE Working Group. EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. Eur J Cancer. 2009;45(6):931–91. doi:10.1016/j.ejca.2008.11.018. Epub 2009 Jan 24

    Article  PubMed  Google Scholar 

  7. Sankaranarayanan R, Swaminathan R, Jayant K, Brenner H. An overview of cancer survival in Africa, Asia, the Caribbean and Central America: the case for investment in cancer health services. IARC Sci Publ. 2011;162:257–91.

    Google Scholar 

  8. Sankaranarayanan R, Swaminathan R, Brenner H, et al. Cancer survival in Africa, Asia, and Central America: a population-based study. Lancet Oncol. 2010;11(2):165–73. doi:10.1016/S1470-2045(09)70335-3. Epub 2009 Dec 10

    Article  PubMed  Google Scholar 

  9. Bhurgri Y, Bhurgri A, Usman A, Pervez S, Kayani N, Bashir I, Ahmed R, Hasan SH. Epidemiological review of head and neck cancers in Karachi. Asian Pac J Cancer Prev. 2006;7(2):195–200.

    PubMed  Google Scholar 

  10. Radoı¨ L, Luce D. A review of risk factors for oral cavity cancer: the importance of a standardized case definition. Community Dent Oral Epidemiol. 2013;41:97–109.

    Article  PubMed  Google Scholar 

  11. Johnson NW, Warnakulasuriya S, Gupta PC, Dimba E, Chindia M, et al. Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions. Adv Dent Res. 2011;23(2):237–46.

    Article  CAS  PubMed  Google Scholar 

  12. Marshall M. An overview of drugs in oceania. In: Lindstorm L, editor. Drugs in Western Pacific societies: relations of substance. Association for Social Anthropology in Oceania Monograph 11. Lanham: University Press of America; 1987. p. 15–21.

    Google Scholar 

  13. Boucher BJ, Mannan N. Metabolic effects of the consumption of Areca catechu. Addict Biol. 2002;7:103–10.

    Article  CAS  PubMed  Google Scholar 

  14. Zain RB, Ikeda N, Gupta PC, Warnakulasuriya S, van Wyk CW, Shrestha P, Axéll T. Oral mucosal lesions associated with betel quid, areca nut and tobacco chewing habits: consensus from a workshop held in Kuala Lumpur, Malaysia, November 25–27, 1996. J Oral Pathol Med. 1999;28(1):1–4. Review

    Article  CAS  PubMed  Google Scholar 

  15. Gardner S, Sidisunthorn P, Ee L. Heritage trees of Penang. Penang: Areca Books; 2011. p. 206. ISBN 978-967-57190-6-6.

    Google Scholar 

  16. Norton SA. Betel: consumption and consequences. J Am Acad Dermatol. 1998;1:38.

    CAS  Google Scholar 

  17. Gupta PC, Warnakulasuriya KAAS. Global epidemiology of areca nut use. Addict Biol. 2002;7:77–83.

    Article  CAS  PubMed  Google Scholar 

  18. Raghavan V, Baruah HK. Arecanut: India’s popular masticatory history, chemistry and utilization. Econ Bot. 1958;12:315–45.

    Article  Google Scholar 

  19. Pindborg JJ, Murthi PR, Bhonsle RB, Gupta PC. Global aspects of tobacco use and its implications for oral health. In: Gupta PC, Hamner J III, Murti P, editors. Control of tobacco-related cancers and other disease. Proceedings of an international symposium; 1990 Jan 15–19. Mumbai: Oxford University Press; 1992. p. 13–23.

    Google Scholar 

  20. Lee CH, Ko AM, Warnakulasuriya S, Yin BL, et al. Intercountry prevalence and practices of betel-quid use in south, southeast and eastern Asia regions and associated oral pre-neoplastic disorders: an international collaborative study by Asian betel-quid consortium of south and east Asia. Int J Cancer. 2011;129(7):1741–51. doi:10.1002/ijc.25809. Epub 2011 Mar 8

    Article  CAS  PubMed  Google Scholar 

  21. Talonu NT. Observations on betel nut use, habituation, addiction and carcinogenesis in Papua New Guineans. P N G Med J. 1989;32:195–7.

    CAS  PubMed  Google Scholar 

  22. Chandra PS, Mullah U. Areca nut: the hidden Indian ‘gateway’ to future tobacco use and oral cancers among youth. Indian J Med Sci. 2007;61(6):319–21.

    Article  PubMed  Google Scholar 

  23. Amarasinghe HK, Usgodaarachchi US, Johnson NW, Lalloo R, Warnakulasuriya S. Public awareness of oral cancer, of oral potentially malignant disorders and of their risk factors in some rural populations in Sri Lanka. Community Dent Oral Epidemiol. 2010;38:540–8.

    Article  PubMed  Google Scholar 

  24. Nair U, Bartsch H, Nair J. Alert for an epidemic of oral cancer due to use of the betel quid substitutes, gutka and pan masala: a review of agents and causative mechanisms. Mutagenesis. 2004;19(4). UK Environmental Mutagen Society.

    Google Scholar 

  25. Amonkar AJ, Padma PR, Bhide SV. Protective effect of hydroxychavicol, a phenolic component of betel leaf, against the tobacco-specific carcinogens. Mutat Res. 1989;210(2):249–53.

    Article  CAS  PubMed  Google Scholar 

  26. Padma PR, Lalitha VS, Amonkar AJ, Bhide SV. Anticarcinogenic effect of betel leaf extract against tobacco carcinogens. Cancer Lett. 1989;45(3):195–202.

    Article  CAS  PubMed  Google Scholar 

  27. Gupta PC. Gutka: a major new tobacco hazard in India. Tob Control. 1999;8(2):134.

    Article  CAS  PubMed  Google Scholar 

  28. Mahapatra S, Kamath R, Shetty BK, Binu VS. Risk of oral cancer associated with gutka and other tobacco products: a hospital-based case control study. J Cancer Res Ther. 2015;11(1):199–203.

    Article  CAS  PubMed  Google Scholar 

  29. Gupta PC. Mouth cancer in India: a new epidemic? J Indian Med Assoc. 1999;97:370–3.

    CAS  PubMed  Google Scholar 

  30. Dongre A, Deshmukh P, Murali N, Garg B. Tobacco consumption among adolescents in rural Wardha: where and how tobacco control should focus its attention? Indian J Cancer. 2008;45:100–6.

    Article  PubMed  Google Scholar 

  31. Gupta PC, Ray CS. Smokeless tobacco and health in India and South Asia. Respirology. 2003;8(4):419–31.

    Article  PubMed  Google Scholar 

  32. Javed F, Altamash M, Klinge B, Engstrom PE. Peridontal conditions and oral symptoms in gutka-chewers with and without type 2 diabetes. Acta Odontol Scand. 2008;66:268–73.

    Article  PubMed  Google Scholar 

  33. Ali NS, Khuwaja AK, Ali T, Hameed R. Smokeless tobacco use among adult patients who visited family practice clinics in Karachi, Pakistan. J Oral Pathol Med. 2009;66:268–73.

    Google Scholar 

  34. Javed F, et al. Oral mucosal disorders associated with the habitual gutka usage: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:857–64.

    Article  PubMed  Google Scholar 

  35. Gangane N, Chawla S, Anshu, Gupta SS, Sharma S. Reassessment of risk factors for oral cancer. Asian Pac J Cancer Prev. 2007;8:243–8.

    PubMed  Google Scholar 

  36. Guha N, Warnakulasuriya S, Vlaanderen J, Straif K. Betel quid chewing and the risk of oral and oropharyngeal cancers: a meta-analysis with implications for cancer control. Int J Cancer. 2014;135(6):1433–43. doi:10.1002/ijc.28643. Epub 2014 May 14

    Article  CAS  PubMed  Google Scholar 

  37. Bhide SV, Shivapurkar NM, Gothoskar SV, Ranadive KJ. Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenolic fraction of betel nut. Br J Cancer. 1979;40:922–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Ranadive KJ, Gothoskar SV, Rao AR, Tezabwalla BU, Ambaye RY. Experimental studies on betel nut and tobacco carcinogenicity. Int J Cancer. 1989;43:728–32.

    Article  Google Scholar 

  39. Surki K, Goldman HM, Wells H. Carcinogenic effect of a dimethyl sulphoxide extract of betel nut on the mucosa of the hamster buccal pouch. Nature. 1971;230:383–4.

    Article  Google Scholar 

  40. Wary KK, Sharan RN. Cytotoxic and cytostatic effects of arecoline and sodium nitrite on human cells in vitro. Int J Cancer. 1991;47:396–400.

    Article  CAS  PubMed  Google Scholar 

  41. Wary KK, Sharan RN. Aqueous extract of betel-nut of Northeastern India induces DNA strand breaks and enhances rate of cell proliferation in vitro. J Cancer Res Clin Oncol. 1988;114:579–82.

    Article  CAS  PubMed  Google Scholar 

  42. Lai KC, Lee TC. Genetic damage in cultured human keratinocytes stressed by long term exposure to areca nut extracts. Mutat Res. 2006;599:66–75.

    Article  CAS  PubMed  Google Scholar 

  43. Chen YJ, Chang JT, Liao CT, Wang HM, Yen TC, Chiu CC, Lu YC, Li HF, Cheng AJ. Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci. 2008;99(8):1507–14. doi:10.1111/j.1349-7006.2008.00863.x.

    Article  CAS  PubMed  Google Scholar 

  44. Jeng JH, Chang MC, Hahn LJ. Role of areca nut in betel quid associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol. 2001;37:477–92.

    Article  CAS  PubMed  Google Scholar 

  45. Shirname LP, Menon MM, Nair J, Bhide SV. Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients. Nutr Cancer. 1983;5:87–91.

    Article  CAS  PubMed  Google Scholar 

  46. Mathew AG. Formation of red color on chewing areca nut with slaked lime. J Food Sci Technol. 1971;8:140–2.

    CAS  Google Scholar 

  47. Reichart PA, Lenz H, Becker J, Mohr U. The black layer on the teeth of betel quid chewers: a light microscopic, micro-radiographic and electron microscopic study. J Oral Pathol. 1985;14:466–75.

    Article  CAS  PubMed  Google Scholar 

  48. Yeh CJ. Fatigue root fracture: a spontaneous root fracture non-endodontically treated teeth. Br Dent J. 1997;182:261–6.

    Article  CAS  PubMed  Google Scholar 

  49. Thomas SJ, Harris R, Ness AR, Taulo J, Maclennan R, Howes N, Bain CJ. Betel quid not containing tobacco and oral leukoplakia: A report on across-sectional study in Papua New Guinea and a meta-analysis of current evidence. Int J Cancer. 2008;123:1871–6.

    Article  CAS  PubMed  Google Scholar 

  50. Hashibe M, Mathew B, Kuruvilla B, Thomas G, Sankaranarayanan R, Maxwell Parkin D, Zhang Z-F. Chewing tobacco, alcohol, and the risk of erythroplakia. Cancer Epidemiol Biomark Prev. 2000;9:639–45.

    CAS  Google Scholar 

  51. Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: review on etiology and pathogenesis. Oral Oncol. 2006;42:561–8.

    Article  CAS  PubMed  Google Scholar 

  52. Reichart PA, Schmidtberg W, Scheifele CH. Betel chewers mucosa in elderly Cambodian women. J Oral Pathol Med. 1996;25:367–70.

    Article  CAS  PubMed  Google Scholar 

  53. Gupta PC, Mehta FS, Dk D, Pindborg JJ, Bhonsle RB, Jalanwalla PN, et al. Incidence of oral cancer and natural history of oral pre-cancerous lesions in a 10year follow-up study of Indian villagers. Community Dent Oral Epidemiol. 1980;8:283–333.

    Article  CAS  PubMed  Google Scholar 

  54. Daftary DK, Bhonsle RB, Murti RB, Pindborg JJ, Mehta FS. An oral lichen planus-like lesion in Indian betel-tobacco chewers. Scand J Dent Res. 1980;88:244–9.

    CAS  PubMed  Google Scholar 

  55. Anand R, Dhingra C, Prasad S, Menon I. Review article: betel nut chewing and its deleterious effects on oral cavity. J Cancer Res Ther. 2014;10(3):499–505.

    PubMed  Google Scholar 

  56. Thomas SJ, Harris R, Ness AR, Taulo J, Maclennan R, Howes N, Bain CJ. Betel quid not containing tobacco and oral leukoplakia: Areport on a cross-sectional study in Papua New Guinea and a meta-analysis of current evidence. Int J Cancer. 2008;123:1871–4.

    Article  CAS  PubMed  Google Scholar 

  57. Lee CH, Ko YC, Huang HL, Chao YY, Tsai CC, Shieh TY, et al. The pre-cancer risk of betel quid chewing, tobacco use, and alcohol consumption in oral leukoplakia in aborgines of Taiwan. J Oral Pathol Med. 2001;30:213–9.

    Article  PubMed  Google Scholar 

  58. Walker DM, Boey G, Mcdonald LA. The pathology of oral cancer. Pathology. 2003;35:376–83.

    Article  PubMed  Google Scholar 

  59. Bouquot JE, Ephros H. Erythroplakia: the dangerous red mucosa. Prac Peridontics Aesthet Dent. 1995;6:9–17.

    Google Scholar 

  60. Pindborg JJ, Sirsat SM. Oral submucous fibrosis. Oral Surg Oral Med Oral Pathol. 1966;22:764–79.

    Article  CAS  PubMed  Google Scholar 

  61. Chung CH, Yang YH, Wang TY, Shieh TY, Warnakulasuriya S. Oral pre-cancerous disorders associated with areca quid chewing, smoking and alcohol drinking in southern Taiwan. J Oral Pathol Med. 2005;34:460–6.

    Article  PubMed  Google Scholar 

  62. Yang YH, Lien YC, Ho PS, Chen CH, Chang JS, Cheng TC, et al. The effects of chewing areca/betel quid with and without cigarette smoking on oral submucous fibrosis and oral mucosal lesions. Oral Dis. 2005;11:88–94.

    Article  PubMed  Google Scholar 

  63. Arakeri G, Brennan PA. Oral submucous fibrosis: an overview of the etiology, pathogenesis, classification, and principles of management. Br J Oral Maxillofac Surg. 2013;51:587–93.

    Article  PubMed  Google Scholar 

  64. Haider SM, Merchant AT, Fikree FF, Rahbar MH. Clinical and functional staging of oral submucous fibrosis. Br J Oral Maxillofac Surg. 2000;38:12–5.

    Article  CAS  PubMed  Google Scholar 

  65. Gupta MK, Mhaske S, Ragavendra R, Imtiaz. Oral submucous fibrosis- current concepts in etiopathogenesis. People’s J Sci Res. 2008;1:39–44.

    Google Scholar 

  66. Jhonson NW. A global view of the epidemiology of oral cancer. Cambridge: Cambridge University Press; 1991. p. 3–326.

    Google Scholar 

  67. Orr IM. Oral cancer in betel chewers in Travancore, it’s etiology, pathology and treatment. Lancet. 1933;2:575–80.

    Article  Google Scholar 

  68. Fells A. Cance of the mouth in Southern India. A summary of 1700 cases. Br Med J. 1908;37:414.

    Google Scholar 

  69. Tobacco habits other than smoking; betel quid and areca nut chewing; and some related nitrosamines. IARC working group. Lyon, 23–30 October 1984. IARC Monogr Eval Carcinog Risk Chem Hum. 1985;37:1–268.

    Google Scholar 

  70. Gupta B, Johnson NW. Systematic review and meta-analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific. PLoS One. 2014;9(11):e113385. doi:10.1371/journal.pone.0113385.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Burnell AC, Yule HA. In: Crooke W, editor. Hobson-Jobson: a glossary of colloquial Anglo Indian words; 1903.

    Google Scholar 

  72. Winstock AR, Trivedy CR, Warnakulasuriya KAAS, Peters TJ. A dependency syndrome related to areca nut use: some medical and psychological aspects among areca nut users in the UK. Addict Biol. 2000;5:173–9.

    Article  CAS  PubMed  Google Scholar 

  73. Benegal V, Rajkumar RP, Muralidharan K. Does areca nut use lead to dependence? Drug Alcohol Depend. 2008;97(1–2):114–21.

    Article  PubMed  Google Scholar 

  74. Yamada T, Hara K, Kadowaki T. Chewing betel quid and risk of metabolic disease, cardiovascular disease, and all-cause mortality: a meta-analysis. PLOS ONE. 2013;8(8):e70679.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. IARC. IARC monographs on the evaluation of carcinogenic risks to humans, Volume 83: Tobacco smoke and involuntary smoking. Lyon: IARC; 2004.

    Google Scholar 

  76. IARC. IARC monographs on the evaluation of carcinogenic risks to humans, volume 96: Alcohol consumption and ethyl carbonate. Lyon: IARC; 2010.

    Google Scholar 

  77. Sankaranarayanan R, Ramadas K, Amarasinghe H, Subramanian S, Jhonson N. Cancer: disease control priorities, Third Edition (Volume 3). Washington: The International Bank for Reconstruction and Development/The World Bank; 2015. Chapter 5

    Google Scholar 

  78. IARC. IARC monographs on the evaluation of carcinogenic risks to humans, volume 89: Smokeless tobacco and some tobacco-specific N-Nitrosamines. Lyon: IARC; 2007.

    Google Scholar 

  79. Ali SMA, Awan MS, Ghaffar S, Salahuddin I, Khan S, Mehraj V, Pervez S. Human Papillomavirus infection in oral squamous cell carcinoma: correlation with histologic variables and survival outcome in a high risk population. Oral Surg. 2008;1(2):96–105. ISSN 1752-2441

    Article  Google Scholar 

  80. IARC. IARC monographs on the evaluation of carcinogenic risks to humans, volume 64: Papillomavirus. Lyon: IARC; 1995.

    Google Scholar 

  81. Werness BA, Levine AJ, Howley PM. Association of human papillomavirus type 16 and 18 E6 proteins with p53. Science. 1990;248:76–9.

    Article  CAS  PubMed  Google Scholar 

  82. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008;26(4):612–9.

    Article  PubMed  Google Scholar 

  83. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Zur Hausen H. Human papillomavirus and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol. 1977;78:1–30.

    CAS  PubMed  Google Scholar 

  85. Franceschi S, Munoz N, Bosch XF, Snijders PJ, Walboomers JM. Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence. Cancer Epidemiol Biomark Prev. 1996;5:567–75.

    CAS  Google Scholar 

  86. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomark Prev. 2005;14:467–75.

    Article  CAS  Google Scholar 

  87. Termine N, Panzarella V, Falaschini S, Russo A, Matranga D, Lo ML, et al. HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988–2007). Ann Oncol. 2008;19:1681–90.

    Article  CAS  PubMed  Google Scholar 

  88. Deschler DG, Richmon JD, Khariwala SS, Ferris RL, Wang MB. The “new” head and neck cancer patient-young, nonsmoker, nondrinker, and HPV positive: evaluation. Otolaryngol Head Neck Surg. 2014;151(3):375–80.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Shukla S, Bharti AC, Mahata S, et al. infection of human papillomavirus in cancers of different human organ sites. Indian J Med Res. 2009;130:222–33.

    CAS  PubMed  Google Scholar 

  90. Young D, Xiao CC, Murphy B, Moore M, Fakhry C, Day TA. Increase in head and neck cancer in younger patients due to human papillomavirus (HPV). Oral Oncol. 2015;51(8):727–30. doi:10.1016/j.oraloncology.2015.03.015. Epub 2015 Jun 9

    Article  PubMed  Google Scholar 

  91. Conway DI, Petticrew M, Marlborough H, Berthiller J, Hashibe M, Macpherson LMD. Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studies. Int J Cancer. 2008;122:2811–9.

    Article  CAS  PubMed  Google Scholar 

  92. Stewart BW, Kleihues P. The cause of: cancer in world cancer report. Lyon: IARC Press; 2003. p. 62–5.

    Google Scholar 

  93. Key TJ, Schatzkin A, Willett WC, Allen NE, Spencer EA, Travis RC. Diet, nutrition and the prevention of cancer. Public Health Nutr. 2004;7(1A):187–200.

    Article  PubMed  Google Scholar 

  94. Llewellyn CD, Linklater K, Bell J, Johnson NW, Warnakulasuriya S. An analysis of risk factors for oral cancer in young people: a case-control study. Oral Oncol. 2004;40:304–13.

    Article  PubMed  Google Scholar 

  95. Hashibe M, Sankaranarayanan R, Thomas G, et al. Alcohol drinking, body mass index and the risk of oral leukoplakia in an Indian population. Int J Cancer. 2000;88:129–34.

    Article  CAS  PubMed  Google Scholar 

  96. Pavia M, Pileggi C, Nobile CG, Angelillo IF. Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr. 2006;83:1126–34.

    CAS  PubMed  Google Scholar 

  97. Maher R, Aga P, Johnson NW, Sankaranarayanan R, Warnakulasuriya S. Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan. Nutr Cancer. 1997;27:41–7.

    Article  CAS  PubMed  Google Scholar 

  98. Sankaranarayanan R, Mathew B, Varghese C, et al. Chemoprevention of oral leukoplakia with vitamin A and beta carotene: an assessment. Oral Oncol. 1997;33:231–6.

    Article  CAS  PubMed  Google Scholar 

  99. Zheng TZ, Boyle P, Hu HF, et al. Dentition, oral hygiene and risk of oral cancer: a case control study in Beijing, Peoples Republic of China. Cancer Causes Control. 1990;1:235–41.

    Article  CAS  PubMed  Google Scholar 

  100. Marshall JR, Graham S, Haughey BP, et al. Smoking, alcohol, dentition and epidemiology of oral cancer. Eur J Cancer B Oral Oncol. 1992;28B:9–15.

    Article  CAS  PubMed  Google Scholar 

  101. World Health Organization. Control of oral cancer in developing countries. Bull World Health Org. 1984;62:817–30.

    Google Scholar 

  102. IARC. International Agency for Research on Cancer (IARC) – Summaries & evaluations: betel-quid and areca-nut chewing. IARC monograph evaluating carcinogenic risk from chemicals to humans, volume 85. Lyon: IARC; 2004. p. 39.

    Google Scholar 

  103. Walsh T, Liu JL, Brocklehurst P, Glenny AM, Lingen M, Kerr AR, Ogden G, Warnakulasuriya S, Scully C. Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. Cochrane Database Syst Rev. 2013;11:CD010173. doi:10.1002/14651858.CD010173.pub2.

    Google Scholar 

  104. Subramanian S, Sankaranarayanan R, Bapat B, Somanathan T, Thomas G, Matthew B, et al. Cost-effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India. Bull World Health Organ. 2009;87(3):200–6.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Rethman MP, Carpenter W, Cohen EE, et al. Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas. J Am Dent Assoc. 2010;141(5):509–20.

    Article  PubMed  Google Scholar 

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Pervez, S., Abro, B. (2017). Oral Cancer and Chewing Habits. In: Al Moustafa, AE. (eds) Development of Oral Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-48054-1_8

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