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Dependency on Non-myogenic Cells for Regeneration of Skeletal Muscle

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Innovations in Molecular Mechanisms and Tissue Engineering

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Humans and other vertebrates have evolved a robust repair mechanism required to respond to overuse, trauma, and disease. In amphibians, some reptiles and fish, entire muscles can be regenerated in response to amputation. Understanding the underlying mechanisms that control these processes has therapeutic implications for individuals where the severe loss of muscle or chronic destabilization has led to the histopathological accumulation of fibrotic scars and fat. Much of the past 30 years has focused on defining the regulatory pathways that control development of skeletal muscle and the additional layers of regulation necessary for recapitulating myogenesis in adults. More recently, it has become clear that efficient skeletal muscle repair and regeneration cannot be understood solely through the lens of a single cell lineage. In this chapter, we discuss current findings on the contribution of the immune system, fibroadipogenic cells and the extracellular matrix in regulating myogenic progenitor cell activation, proliferation, and differentiation of myotubes in response to injury or amputation.

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Authors and Affiliations

  1. School of Life Sciences, Arizona State University, Life Sciences C Bldg, Tempe, AZ, 85287-4501, USA

    Cherie Alissa Lynch, Alexander B. Andre & Alan Rawls

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  1. Cherie Alissa Lynch
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  2. Alexander B. Andre
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  3. Alan Rawls
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Correspondence to Alan Rawls .

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Editors and Affiliations

  1. School of Life Sciences Arizona State University, Tempe, Arizona, USA

    Jeanne Wilson-Rawls

  2. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA

    Kenro Kusumi

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Lynch, C.A., Andre, A.B., Rawls, A. (2016). Dependency on Non-myogenic Cells for Regeneration of Skeletal Muscle. In: Wilson-Rawls, J., Kusumi, K. (eds) Innovations in Molecular Mechanisms and Tissue Engineering. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-44996-8_3

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