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Genetics of (Premature) Coronary Artery Disease

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Clinical Cardiogenetics

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Abstract

Coronary artery disease (CAD) and its major complication, myocardial infarction (MI), remain the number one cause of death in industrialized society, causing approximately one in every six deaths in the United States in 2010. CAD is the clinical manifestation of a chronic pathomorphological process that occurs in the vascular wall. Carl Müller (1886–1983) was the first to identify a link between high plasma cholesterol, xanthoma, and premature coronary heart disease in 1939, providing early evidence of a genetic component of CAD and its association with cholesterol. Today, it is well established that CAD arises from the interaction of multiple genetic and environmental factors. Likewise, a multifactorial etiology applies to many of the underlying cardiovascular risk factors, including hypercholesterolemia, hypertension, diabetes mellitus, and smoking.

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Authors and Affiliations

  1. Institute for Integrative and Experimental Genomics, University of Lübeck, Maria-Goeppert-Str. 1, 23562, Lübeck, Germany

    Jeanette Erdmann PhD

  2. Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany

    Heribert Schunkert MD

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Correspondence to Jeanette Erdmann PhD .

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Editors and Affiliations

  1. Department of Cardiology, St. Elisabeth-TweeSteden Ziekenhuis, Tilburg, The Netherlands

    Hubert F. Baars

  2. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands

    Pieter A. F. M. Doevendans

  3. Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands

    Arjan C. Houweling

  4. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

    J. Peter van Tintelen

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Erdmann, J., Schunkert, H. (2016). Genetics of (Premature) Coronary Artery Disease. In: Baars, H., Doevendans, P., Houweling, A., van Tintelen, J. (eds) Clinical Cardiogenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-44203-7_22

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