Abstract
The therapeutic window of radiotherapy is defined by the balance between the tumor control probability (TCP) and the normal tissue complication probability (NTCP). The tremendous evolution from bony-landmark two-dimensional radiotherapy over CT-based three-dimensional radiotherapy towards highly-conformal radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) has broadened the therapeutic window substantially.
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References
Verellen D, De Ridder M, Linthout N, Tournel K, Soete G, Storme G (2007) Innovations in image-guided radiotherapy. Nat Rev Cancer 7(12):949–960
Jaffray DA (2012) Image-guided radiotherapy: from current concept to future perspectives. Nat Rev Clin Oncol 9(12):688–699
van Herk M, Remeijer P, Rasch C, Lebesque JV (2000) The probability of correct target dosage: dose-population histograms for deriving treatment margins in radiotherapy. Int J Radiat Oncol Biol Phys 47(4):1121–1135
Stroom JC, de Boer HC, Huizenga H, Visser AG (1999) Inclusion of geometrical uncertainties in radiotherapy treatment planning by means of coverage probability. Int J Radiat Oncol Biol Phys 43(4):905–919
Nijkamp J, Swellengrebel M, Hollmann B et al (2012) Repeat CT assessed CTV variation and PTV margins for short- and long-course pre-operative RT of rectal cancer. Radiother Oncol 102(3):399–405
Bondar L, Intven M, Burbach JP et al (2014) Statistical modeling of CTV motion and deformation for IMRT of early-stage rectal cancer. Int J Radiat Oncol Biol Phys 90(3):664–672
Kasabasić M, Faj D, Ivković A, Jurković S, Belaj N (2010) Rotation of the sacrum during bellyboard pelvic radiotherapy. Med Dosim 35(1):28–30
Kim TH, Chie EK, Kim DY, Park SY, Cho KH, Jung KH et al (2005) Comparison of the belly board device method and the distended bladder method for reducing irradiated small bowel volumes in preoperative radiotherapy of rectal cancer patients. Int J Radiat Oncol Biol Phys 62(3):769–775
Nijkamp J, Doodeman B, Marijnen C, Vincent A, van Vliet-Vroegindeweij C (2012) Bowel exposure in rectal cancer IMRT using prone, supine, or a belly board. Radiother Oncol 102(1):22–29
Nuyttens JJ, Robertson JM, Yan D, Martinez A (2002) The variability of the clinical target volume for rectal cancer due to internal organ motion during adjuvant treatment. Int J Radiat Oncol Biol Phys 53(2):497–503
Nijkamp J, de Jong R, Sonke JJ, van Vliet C, Marijnen C (2009) Target volume shape variation during irradiation of rectal cancer patients in supine position: comparison with prone position. Radiother Oncol 93(2):285–292
Nijkamp J, de Jong R, Sonke JJ, Remeijer P, van Vliet C, Marijnen C (2009) Target volume shape variation during hypo-fractionated preoperative irradiation of rectal cancer patients. Radiother Oncol 92(2):202–209
Nijkamp J, Swellengrebel M, Hollmann B et al (2012) Repeat CT assessed CTV variation and PTV margins for short- and long-course pre-operative RT of rectal cancer. Radiother Oncol 102(3):399–405
Yan D, Vicini F, Wong J, Martinez A (1997) Adaptive radiation therapy. Phys Med Biol 42:123–132
Nijkamp J, Marijnen C, van Herk M, van Triest B, Sonke JJ (2012) Adaptive radiotherapy for long course neo-adjuvant treatment of rectal cancer. Radiother Oncol 103(3):353–359
Maggiulli E, Fiorino C, Passoni P et al (2012) Characterisation of rectal motion during neo-adjuvant radiochemotherapy for rectal cancer with image-guided tomotherapy: implications for adaptive dose escalation strategies. Acta Oncol 51(3):318–324
Roels S, Slagmolen P, Nuyts J et al (2008) Biological image-guided radiotherapy in rectal cancer: is there a role for FMISO or FLT, next to FDG? Acta Oncol 47(7):1237–1248
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Haustermans, K., Joye, I. (2018). When Should IGRT Be Done?. In: Valentini, V., Schmoll, HJ., van de Velde, C. (eds) Multidisciplinary Management of Rectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-43217-5_23
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