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Therapeutic Index and Its Clinical Significance

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Practical Radiation Oncology

Abstract

The main purpose of delivering curative radiotherapy is maximizing cure with minimal normal tissue complications. The therapeutic index is a correlation of tumor control probability and normal tissue complication probability at different doses of radiation. Usually tumors with a wide therapeutic index are easily curable by radiotherapy. This chapter aims at understanding the definition of therapeutic index and its clinical implications.

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References

  1. Chargari C, Magne N, Guy JB, Rancoule C, Levy A, Goodman KA, et al. Optimize and refine therapeutic index in radiation therapy: overview of a century. Cancer Treat Rev. 2016;45:58–67.

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  2. Beasley M, Driver D, Dobbs HJ. Complications of radiotherapy: improving the therapeutic index. Cancer Imaging. 2005;5:78–84.

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  3. Montay-Gruel P, Meziani L, Yakkala C, Vozenin MC. Expanding the therapeutic index of radiation therapy by normal tissue protection. Br J Radiol. 2018:20180008. https://doi.org/10.1259/bjr.20180008.

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Benson, R., Mallick, S. (2020). Therapeutic Index and Its Clinical Significance. In: Mallick, S., Rath, G., Benson, R. (eds) Practical Radiation Oncology. Springer, Singapore. https://doi.org/10.1007/978-981-15-0073-2_31

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  • DOI: https://doi.org/10.1007/978-981-15-0073-2_31

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-0072-5

  • Online ISBN: 978-981-15-0073-2

  • eBook Packages: MedicineMedicine (R0)

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