Abstract
With as high as 60 % of drugs in company pipelines exhibiting poor aqueous solubility, the ability to successfully develop a poorly water-soluble drug has become essential. Gaining a detailed understanding of a compound through preformulation studies can be especially challenging for poorly water-soluble drugs limiting their development. Therefore, this chapter focuses on the application of preformulation studies essential in understanding a poorly water-soluble drug, including solubility studies, solid-state characterization of the active ingredient and formulations thereof, and in vitro and in vivo testing of the lead formulations.
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Ellenberger, D., O’Donnell, K.P., Williams, R.O. (2016). Optimizing the Formulation of Poorly Water-Soluble Drugs. In: Williams III, R., Watts, A., Miller, D. (eds) Formulating Poorly Water Soluble Drugs. AAPS Advances in the Pharmaceutical Sciences Series, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-42609-9_2
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