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Retroperitoneal Tumors in Adults

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Urologic Oncology

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Abstract

Retroperitoneal tumors are a heterogeneous group of rare tumors arising in the retroperitoneum, but not from the retroperitoneal organs. Most retroperitoneal tumors are malignant and derive from soft tissue, sarcomas being the most common. Primary extragonadal germ cell tumors and primary retroperitoneal lymphomas are rare differential diagnoses. A hallmark of malignant retroperitoneal soft tissue tumors is their large size upon diagnosis and their poor prognosis. CT scans and core needle biopsies are the mainstay of diagnosis. Extended radical and complete en bloc surgery is the only potentially curative treatment. Surgery should always be image-guided and never be exploratory. Despite surgery, local recurrence is common and accounts for most of the disease’s morbidity. Even though the scientific evidence is weak, neoadjuvant chemotherapy and/or preoperative radiation might be of some value for selected patients and histological subtypes. Guidelines strongly recommend a multidisciplinary treatment approach at a specialized center and data collection in international registries. Since all these cases are rare, advances can only be made in collaboration.

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References

  • Anaya DA, et al. Establishing prognosis in retroperitoneal sarcoma: a new histology-based paradigm. Ann Surg Oncol. 2009;16(3):667–75.

    Article  Google Scholar 

  • Armstrong JR, Cohn I Jr. Primary malignant retroperitoneal tumors. Am J Surg. 1965;110(6):937–43.

    Article  CAS  Google Scholar 

  • Avances C, et al. CCAFU’s contribution to the French National Cancer Institute’s reference frame: retroperitoneal sarcomas. Prog Urol J Assoc Fr Urol Soc Fr Urol. 2013;23(Suppl 2):S161–6.

    Google Scholar 

  • Baldini EH, et al. Treatment guidelines for preoperative radiation therapy for retroperitoneal sarcoma: preliminary consensus of an international expert panel. Int J Radiat Oncol Biol Phys. 2015;92(3):602–12.

    Article  Google Scholar 

  • Bjerkehagen B, et al. Radiation-induced sarcoma: 25-year experience from the Norwegian Radium Hospital. Acta Oncol. 2008;47(8):1475–82.

    Article  CAS  Google Scholar 

  • Bonvalot S, et al. Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(1):31–7.

    Article  Google Scholar 

  • Bremjit PJ, et al. A contemporary large single-institution evaluation of resected retroperitoneal sarcoma. Ann Surg Oncol. 2014;21(7):2150–8.

    Article  Google Scholar 

  • Brennan C, et al. Solid malignant retroperitoneal masses-a pictorial review. Insights Imaging. 2014;5(1):53–65.

    Article  Google Scholar 

  • Bubendorf L, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol. 2000;31(5):578–83.

    Article  CAS  Google Scholar 

  • Burningham Z, et al. The epidemiology of sarcoma. Clin Sarcoma Res. 2012;2(1):14.

    Article  Google Scholar 

  • Chen L, et al. Hematologic malignancies with primary retroperitoneal presentation: clinicopathologic study of 32 cases. Arch Pathol Lab Med. 2005;129(5):655–60.

    PubMed  Google Scholar 

  • Erzen D, Sencar M, Novak J. Retroperitoneal sarcoma: 25 years of experience with aggressive surgical treatment at the Institute of Oncology, Ljubljana. J Surg Oncol. 2005;91(1):1–9.

    Article  Google Scholar 

  • ESMO Guidelines Working Group. Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. 2012;23(Suppl 7):vii92–9.

    Google Scholar 

  • Feng M, et al. Long-term outcomes after radiotherapy for retroperitoneal and deep truncal sarcoma. Int J Radiat Oncol Biol Phys. 2007;69(1):103–10.

    Article  Google Scholar 

  • Fletcher CDM, et al. WHO classification of tumours of soft tissue and bone. 4th ed. Geneva: WHO Press; 2014.

    Google Scholar 

  • Gemici K, et al. Management of patients with retroperitoneal tumors and a review of the literature. World J Surg Oncol. 2015;13:143.

    Article  Google Scholar 

  • Gronchi A, et al. Retroperitoneal soft tissue sarcomas: patterns of recurrence in 167 patients treated at a single institution. Cancer. 2004;100(11):2448–55.

    Article  Google Scholar 

  • Gronchi A, et al. Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(1):24–30.

    Article  Google Scholar 

  • Gronchi A, et al. Variability in patterns of recurrence after resection of primary retroperitoneal sarcoma (RPS): a report on 1007 patients from the multi-institutional collaborative RPS working group. Ann Surg. 2016;263(5):1002–9.

    Article  Google Scholar 

  • Hueman MT, Herman JM, Ahuja N. Management of retroperitoneal sarcomas. Surg Clin North Am. 2008;88(3):583–97. vii

    Article  Google Scholar 

  • Jaques DP, et al. Management of primary and recurrent soft-tissue sarcoma of the retroperitoneum. Ann Surg. 1990;212(1):51–9.

    Article  CAS  Google Scholar 

  • Jo VY, Fletcher CD. WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition. Pathology. 2014;46(2):95–104.

    Article  CAS  Google Scholar 

  • Kim KS, et al. Radiation-induced sarcoma: a 15-year experience in a single large tertiary referral center. Cancer Res Treat Off J Kor Cancer Assoc. 2016;48(2):650–7.

    CAS  Google Scholar 

  • Krege S, et al. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. Eur Urol. 2008;53(3):478–96.

    Article  Google Scholar 

  • Le Pechoux C, et al. Should adjuvant radiotherapy be administered in addition to front-line aggressive surgery (FAS) in patients with primary retroperitoneal sarcoma? Ann Oncol Off J Eur Soc Med Oncol. 2013;24(3):832–7.

    Article  Google Scholar 

  • Lewis JJ, et al. Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg. 1998;228(3):355–65.

    Article  CAS  Google Scholar 

  • Mariani A, et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol Oncol. 2008;109(1):11–8.

    Article  Google Scholar 

  • Mendenhall WM, et al. Retroperitoneal soft tissue sarcoma. Cancer. 2005;104(4):669–75.

    Article  Google Scholar 

  • Miura JT, et al. Impact of chemotherapy on survival in surgically resected retroperitoneal sarcoma. Eur J Surg Oncol: J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2015;41(10):1386–92.

    Article  CAS  Google Scholar 

  • Murez T, et al. CCAFU french national guidelines 2016–2018 on retroperitoneal sarcoma. Prog Urol J Assoc Fr Urol Soc Fr Urol. 2016;27(Suppl 1):S183–90.

    Google Scholar 

  • Osswald M, et al. Treatment of a population based sample of men diagnosed with testicular cancer in the United States. Urol Oncol. 2009;27(6):604–10.

    Article  Google Scholar 

  • Pawlik TM, et al. Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma. Ann Surg Oncol. 2006;13(4):508–17.

    Article  Google Scholar 

  • Pervaiz N, et al. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer. 2008;113(3):573–81.

    Article  Google Scholar 

  • Pinson CW, et al. Long-term results with primary retroperitoneal tumors. Arch Surg. 1989;124(10):1168–73.

    Article  CAS  Google Scholar 

  • Pliess G. Proceedings: retroperitoneal tumors: pathology (author’s transl). Langenbecks Arch Chir. 1973;334:127–40.

    Article  CAS  Google Scholar 

  • Porpiglia AS, Reddy SS, Farma JM. Retroperitoneal Sarcomas. Surg Clin N Am. 2016;96(5):993–1001.

    Article  Google Scholar 

  • Porter GA, Baxter NN, Pisters PW. Retroperitoneal sarcoma: a population-based analysis of epidemiology, surgery, and radiotherapy. Cancer. 2006;106(7):1610–6.

    Article  Google Scholar 

  • Ribeiro Gomes J, Belotto M, D’Alpino Peixoto R. The role of surgery for unusual sites of metastases from colorectal cancer: a review of the literature. Eur J Surg Oncol. 2017;43(1):15–19.

    Article  CAS  Google Scholar 

  • Robert-Koch-Institute. Zentrum für Krebsregisterdaten. www.krebsdaten.de. 2016.

  • Roett MA, Evans P. Ovarian cancer: an overview. Am Fam Physician. 2009;80(6):609–16.

    PubMed  Google Scholar 

  • Schmalz O. Retroperitoneal tumors. Der Urol Ausg A. 2016;55(6):748–55.

    Article  CAS  Google Scholar 

  • Scholz M, et al. Extragonadal retroperitoneal germ cell tumor: evidence of origin in the testis. Ann Oncol Off J Eur Soc Med Oncol. 2002;13(1):121–4.

    Article  CAS  Google Scholar 

  • Sheth GR, et al. Radiation-induced sarcoma of the breast: a systematic review. Oncologist. 2012;17(3):405–18.

    Article  Google Scholar 

  • Singer S, et al. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 2003;238(3):358–70; discussion 370–1

    PubMed  PubMed Central  Google Scholar 

  • Stein ME, et al. Radiation-induced sarcoma following curative radiotherapy for testicular seminoma: case report and brief review of the literature. Tumori. 1997;83(3):721–3.

    Article  CAS  Google Scholar 

  • Strauss DC, Hayes AJ, Thomas JM. Retroperitoneal tumours: review of management. Ann R Coll Surg Engl. 2011;93(4):275–80.

    Article  Google Scholar 

  • Tambo M, et al. Clinicopathological review of 46 primary retroperitoneal tumors. Int J Urol Off J Jpn Urol Assoc. 2007;14(9):785–8.

    Google Scholar 

  • Trans-Atlantic RPS Working Group. Management of primary retroperitoneal sarcoma (RPS) in the adult: a consensus approach from the Trans-Atlantic RPS Working Group. Ann Surg Oncol. 2015;22(1):256–63.

    Google Scholar 

  • Trans-Atlantic RPS Working Group. Management of recurrent retroperitoneal sarcoma (RPS) in the adult: a consensus approach from the Trans-Atlantic RPS Working Group. Ann Surg Oncol. 2016;23(11):3531–40.

    Google Scholar 

  • Van Roggen JF, Hogendoorn PC. Soft tissue tumours of the retroperitoneum. Sarcoma. 2000;4(1–2):17–26.

    Article  Google Scholar 

  • Virseda Rodriguez JA, et al. Primary retroperitoneal tumors: review of our 10-year case series. Arch Esp Urol. 2010;63(1):13–22.

    Article  Google Scholar 

  • von Mehren M, et al. Soft tissue sarcoma, version 2.2014. J Natl Compr Cancer Netw JNCCN. 2014;12(4):473–83.

    Article  Google Scholar 

  • Zlotecki RA, et al. Adjuvant radiation therapy for resectable retroperitoneal soft tissue sarcoma: the University of Florida experience. Am J Clin Oncol. 2005;28(3):310–6.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Urology, University Homburg/Saar, Homburg, Germany

    Claudius Füllhase

  2. Department of Urology, Heidelberg University, Heidelberg, Germany

    Nina Harke

  3. Department of Urology, University of Essen, Essen, Germany

    Christian Niedworok

  4. Department of Urology, University of Rostock, Rostock, Germany

    Chris Protzel & Oliver W. Hakenberg

Authors
  1. Claudius Füllhase
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  2. Nina Harke
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  3. Christian Niedworok
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  4. Chris Protzel
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  5. Oliver W. Hakenberg
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Corresponding author

Correspondence to Claudius Füllhase .

Editor information

Editors and Affiliations

  1. Urologie, Univ Lübeck, Lübeck, Schleswig-Holstein, Germany

    Axel Merseburger

  2. Dept. of Urology, University of Regensburg St. Josef Medical Centre, Regensburg, Germany

    Maximilian Burger

Section Editor information

  1. Universitätsklinikum Rostock , Urologische Klinik und Poliklinik, Rostock, Germany

    Chris Protzel

  2. Division of Oncological Urology, Department of Urology, University of Köln, Köln, Germany

    Axel Heidenreich

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Füllhase, C., Harke, N., Niedworok, C., Protzel, C., Hakenberg, O.W. (2018). Retroperitoneal Tumors in Adults. In: Merseburger, A., Burger, M. (eds) Urologic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42603-7_42-1

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  • DOI: https://doi.org/10.1007/978-3-319-42603-7_42-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42603-7

  • Online ISBN: 978-3-319-42603-7

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