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Epidemiology of Pancreatic Cancer

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Pathology and Epidemiology of Cancer

Abstract

Pancreatic cancer is the most rapidly lethal cancer; only 7 % of patients survive 5 years. Men are slightly more likely to develop this cancer than women, and African American men have the highest incidence rates. Established risk factors for pancreatic cancer include smoking, long-standing diabetes, chronic pancreatitis, obesity, heavy alcohol intake and family history. Genetic polymorphisms in the ABO gene have also been associated with modest risks of pancreatic cancer, and individuals who have blood type A or B have slightly higher risk than those with type O. Recent research suggests that periodontal infection and gastric ulcers may increase the risk of pancreatic cancer, while allergies may decrease risk. With the exception of red meat intake (and cooking practices), dietary factors have not been consistently associated with risk of pancreatic cancer. Studies examining mutations in tumor tissue have not identified clear associations between risk factors and tumor mutations, but few observational studies have had tumor tissue to address these questions.

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Authors and Affiliations

  1. Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA

    Dominique S. Michaud

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  1. Dominique S. Michaud
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Editors and Affiliations

  1. Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

    Massimo Loda

  2. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

    Lorelei A. Mucci

  3. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

    Megan L. Mittelstadt

  4. King’s College London, Guy’s Hospital, London, United Kingdom

    Mieke Van Hemelrijck

  5. Department of Pathology, Dana-Farber Cancer Institute and Brigham & Women’s Hospital, Boston, Massachusetts, USA

    Maura Bríd Cotter

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Michaud, D.S. (2017). Epidemiology of Pancreatic Cancer. In: Loda, M., Mucci, L., Mittelstadt, M., Van Hemelrijck, M., Cotter, M. (eds) Pathology and Epidemiology of Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-35153-7_25

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