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Body mass index and physical activity as risk factors for pancreatic cancer: the Multiethnic Cohort Study

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Abstract

Objective

To examine body mass index (BMI) and physical activity as risk factors for pancreatic cancer.

Methods

Eight-year prospective data from 77,255 men and 90,175 women including 237 and 235 pancreatic cancer cases, respectively, in the Hawaii-Los Angeles Multiethnic Cohort Study were analyzed. Participants completed a questionnaire that included questions on body weight, height, and physical activity. Cox proportional hazards models were calculated to estimate relative risks (RR) of pancreatic cancer by levels of BMI and total physical activity (as metabolic equivalents (METs)) adjusted for several potential confounders.

Results

Obesity (BMI ≥ 30 kg/m2) was associated with an increased pancreatic cancer risk in men (RR = 1.51 (95% CI: 1.02–2.26)), but a reduced risk in women (RR = 0.65 (95% CI: 0.43–0.99)). In men the risk was higher in never smokers than in current or former smokers, though differences were not statistically significant. Physical activity was not associated with pancreatic cancer risk in either men or women.

Conclusion

The findings suggest, that a BMI of ≥ 30 kg/m2 may be a risk factor for pancreatic cancer in men. No evidence of an effect of physical activity on risk was found.

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Acknowledgments

This work was supported in part by Grant R37 CA054281 from the National Cancer Institute, U.S. Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the agency.

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Authors and Affiliations

  1. Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA

    Ute Nöthlings, Lynne R. Wilkens, Suzanne P. Murphy, Jean H. Hankin & Laurence N. Kolonel

  2. University of Southern California, Los Angeles, CA, USA

    Brian E. Henderson

Authors
  1. Ute Nöthlings
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  2. Lynne R. Wilkens
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  3. Suzanne P. Murphy
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  4. Jean H. Hankin
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  5. Brian E. Henderson
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  6. Laurence N. Kolonel
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Correspondence to Ute Nöthlings.

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Nöthlings, U., Wilkens, L.R., Murphy, S.P. et al. Body mass index and physical activity as risk factors for pancreatic cancer: the Multiethnic Cohort Study. Cancer Causes Control 18, 165–175 (2007). https://doi.org/10.1007/s10552-006-0100-0

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  • DOI: https://doi.org/10.1007/s10552-006-0100-0

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