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Role of PACAP in Astrocytes and Astrocytic Tumors

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Pituitary Adenylate Cyclase Activating Polypeptide — PACAP

Part of the book series: Current Topics in Neurotoxicity ((Current Topics Neurotoxicity,volume 11))

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Abstract

In the central nervous system (CNS), astrocytes are the most numerous among glial cells and have diverse physiological functions. These cells also play an important role in many CNS disorders and pathologies. Pituitary adenylate cyclase activating polypeptide (PACAP) is abundantly expressed in the CNS, acting as a neuroprotectant against various neurological threats. PACAP also has been studied as an astrocytic regulator from diversified aspects. PACAP receptor expression has dynamically changed in pathological condition. In this chapter, we summarize the expression and function of PACAP and PACAP receptors in astrocytes and astrocytic tumors, and discuss the role of PACAP in physiological and pathological conditions.

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Acknowledgments

This work was supported by JSPS KAKENHI 23249079, 15K15670, 15H04394 and by a research grant from Toyama First Bank Scholarship Foundation.

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Authors and Affiliations

  1. Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama-shi, Toyama, 930-8555, Japan

    Tomoya Nakamachi

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  1. Tomoya Nakamachi
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Correspondence to Tomoya Nakamachi .

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Editors and Affiliations

  1. Department of Anatomy MTA-PTE “Lendulet” PACAP Research Team, University of Pecs, Pecs, Hungary

    Dora Reglodi

  2. Department of Anatomy MTA-PTE “Lendulet” PACAP Research Team, University of Pecs, Pecs, Hungary

    Andrea Tamas

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Nakamachi, T. (2016). Role of PACAP in Astrocytes and Astrocytic Tumors. In: Reglodi, D., Tamas, A. (eds) Pituitary Adenylate Cyclase Activating Polypeptide — PACAP. Current Topics in Neurotoxicity, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-319-35135-3_27

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