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Stem Cell Clinical Trials for Multiple Sclerosis: The Past, Present and Future

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Neurological Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that is associated by tissue inflammation and nerve cells apoptosis. The prevalence of this disease in women is two to three times more than men, and it is more frequent in the 20–40 years of age. During development, the nervous system emerges from neural stem cell (NSCs) that have self-renewal potential and differentiate into neural and glial cell. Two types of stem cells populating in patients with MS; one is hematopoietic stem cell (HSC) and others are mesenchymal stem cells (MSC). Despite major knowledge advances since the discovery of stem cells, the field is so broad and there are still many valuable opportunities to work. Every year, many people suffer from their internal organs damages that lead to life-threatening complications or losing their lives. Laboratory production of new tissue that could potentially be transplanted into the patient’s body can be a solution to this big problem.

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Acknowledgements

The authors would like to acknowledge the help of all the people that took part in the professionally advising process, more specifically, to the Prof. Bagher Larijani and Dr. Najmaldin Saki. Without their support, this book chapter would not have become a reality.

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Authors and Affiliations

  1. Health Research Institute, Thalassemia and Hemoglobinopathies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fakher Rahim

  2. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, IR, Iran

    Babak Arjmand

Authors
  1. Fakher Rahim
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  2. Babak Arjmand
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Correspondence to Fakher Rahim .

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Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Rahim, F., Arjmand, B. (2017). Stem Cell Clinical Trials for Multiple Sclerosis: The Past, Present and Future. In: Pham, P. (eds) Neurological Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-33720-3_9

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