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Stem Cells Therapy for Multiple Sclerosis

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Stem Cell-based Therapy for Neurodegenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1266))

Abstract

Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system (CNS) associated with inflammatory plaques of white matter demyelination, oligodendrocyte destruction, reactive gliosis and axonal degeneration. In this chapter, we first review the pathological process of axonal degeneration in MS and discuss how these changes cause clinical symptoms of MS. We then discuss the pharmacological treatment to improve the clinical symptoms. Finally, we highlight how the autologous hematopoietic stem cell transplantation (AHSCT) can be effective for aggressive MS patients, who fail to respond to drug therapies, and also propose the future challenges of AHSCT.

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Author information

Authors and Affiliations

  1. ACE Cells Lab Ltd., Sheffield, UK

    Nassim Abi Chahine

  2. Department of Neurosciences, University of California - San Diego, La Jolla, CA, USA

    Paul Lu

Authors
  1. Nassim Abi Chahine
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  2. Paul Lu
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Correspondence to Nassim Abi Chahine .

Editor information

Editors and Affiliations

  1. The Second Affiliated Hospital, Shandong University, Jinan, Shandong, China

    Fabin Han

  2. School of Medicine, University of California at San Diego, La Jolla, CA, USA

    Pengzhe (Paul) Lu

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Abi Chahine, N., Lu, P. (2020). Stem Cells Therapy for Multiple Sclerosis. In: Han, F., Lu, P.(. (eds) Stem Cell-based Therapy for Neurodegenerative Diseases. Advances in Experimental Medicine and Biology, vol 1266. Springer, Singapore. https://doi.org/10.1007/978-981-15-4370-8_7

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