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Molecular Organization of the Skin Barrier

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Agache's Measuring the Skin

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Abstract

The skin’s barrier is constituted by a lipid matrix situated between the cells of the horny layer. It has a unique molecular organization based on stacked bilayers of fully-extended ceramides with cholesterol associated with the ceramide sphingoid moiety. Its physical state is gel-like. The presented near-native subnanometer-resolution data opens the door for molecular dynamics probing of the skin barrier’s physico-chemical properties.

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Author information

Authors and Affiliations

  1. Department of Cell and Molecular Biology (CMB), Karolinska Institutet, and Dermatology Clinic, Karolinska University Hospital, Stockholm, Sweden

    Lars Norlén

Authors
  1. Lars Norlén
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Correspondence to Lars Norlén .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University Hospital of Besançon, Besançon, France

    Philippe Humbert

  2. Center for Study and Research on the Integuments, Department of Dermatology, University Hospital of Besançon, Besançon, France

    Ferial Fanian

  3. Department of Dermatology, School of Medicine, University of California, San Francisco, California, USA

    Howard I. Maibach

  4. Department of Dermatology, University Hospital of Besançon, Besançon, France

    Pierre Agache

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Norlén, L. (2017). Molecular Organization of the Skin Barrier. In: Humbert, P., Fanian, F., Maibach, H., Agache, P. (eds) Agache's Measuring the Skin. Springer, Cham. https://doi.org/10.1007/978-3-319-32383-1_24

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  • DOI: https://doi.org/10.1007/978-3-319-32383-1_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32381-7

  • Online ISBN: 978-3-319-32383-1

  • eBook Packages: MedicineReference Module Medicine

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