Abstract
A frequent cause of hydrocephalus is the intraventricular hemorrhage (IVH) that is almost always related with prematurity. This condition is often the origin of important cognitive, motor, and behavioral sequels. IVH typically occurs during the first 3 days of postnatal life. Several clinical manifestations indicate its occurrence, although some hemorrhagic episodes can evolve with a clinically silent pattern. IVH can also present as a catastrophic event that calls for immediate attention. Ultrasonography (US) is the preferred tool used for its diagnosis and for follow-up evaluation. Given that the children’s outcomes depend on the extent of the hemorrhage and to the presence of associated parenchymal lesions, some grading systems for assessing the resulting brain damage have been developed, among them the Papile’s grading scale. Several medical, pharmacological, and surgical temporizing methods are used aimed at avoiding or delaying the eventual placement of a permanent CSF shunt.
At present, many authors manifest a reasonable reluctance to operate on small, preterm, infants, given the potential for well-known complications of CSF shunting. On the other hand, delaying definitive surgery in the presence of hydrocephalus might cause a progressive or even an irreversible brain damage. Recently, endoscopic procedures are being evaluated that show a success rate of approximately 30%, although CSF shunting remains as the most dependable surgical treatment. Morbidity and mortality of posthemorrhagic hydrocephalus (PHH) seems to be closely related to the severity and extension of the initial bleeding and to associated complications and comorbidities. Preventive measures for decreasing the risks for IVH are of utmost importance. In spite of advances in perinatal care, there exists a growing awareness of the need of improving research on prevention, on medical and/or surgical management, and on the rehabilitation and social integration of the affected individuals.
References
Ballabh P (2014) Pathogenesis and prevention of intraventricular hemorrhage. Clin Perinatol 41:47–67
Bravo C, Cano P, Conde R et al (2011) Posthemorrhagic hydrocephalus in the preterm infant: current evidence in diagnosis and treatment. Neurocirugia (Astur) 23:381–400 (Span)
Bruno CJ, Beslow LA, Witmer CM et al (2014) Hemorrhage stroke in term and late preterm neonates. Arch Dis Child Fetal Neonatal Ed 99:F48–F53
Camacho A, Simón R, Muñoz A et al (2008) Syringomyelia secondary to posthemorrhagic hydrocephalus in a preterm infant. Pediatr Neurol 38:211–214
Cavalheiro S, Fernandez Moron A, Zymberg ST, Dastoli P (2003) Fetal hydrocephalus- prenatal treatment. Childs Nerv Syst 19:561–573
Christian EA, Jin DL, Attenello F et al (2016a) Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000–2010. J Neurosurg Pediatr 17:260–269
Christian EA, Melamed EF, Peck E et al (2016b) Surgical management of hydrocephalus secondary to intraventricular hemorrhage in the preterm infant. J Neurosurg Pediatr 17:276–284
Counsell SJ, Rutherford MA, Cowan FM, Edwards AD (2003) Magnetic resonance imaging of preterm brain injury. Arch Dis Child Fetal Neonatal Ed 88:F269–F274
Davies MW, Swaminathan M, Chuang SL, Betheras FR (2000) Reference ranges for the linear dimensions of the intracranial ventricles in preterm neonates. Arch Dis Child Fetal Neonatal Ed 82:F218–F223
Del Bigio MR, Di Curzio DL (2016) Nonsurgical therapy for hydrocephalus: a comprehensive and critical review. Fluids Barriers CNS 13:3
Engle WA (2004) Policy statement: age terminology during the perinatal period. Pediatrics 114:1362–1364
Fountain DM, Chari A, Allen D, James G (2016) Comparison of the use of ventricular access devices and ventriculosubgaleal shunts in posthaemorrhagic hydrocephalus: systematic review and meta-analysis. Childs Nerv Syst 32:259–267
Iannelli A, Rea G, Di Rocco C (2005) CSF shunt removal in children with hydrocephalus. Acta Neurochir 47:503–507
Kennedy CR, International PHVD Drug Trial Group (1998) International randomised controlled trial of acetazolamide and furosemide in posthaemorrhagic ventricular dilatation in infancy. Lancet 352:433–440
Kulkarni A, Robin D, Drake JM (2004) An instrument to measure the health status in children with hydrocephalus: the Hydrocephalus Outcome Questionnaire. J Neurosurg Pediatr 101(2 Suppl):134–140
Luciano R, Baranello G, Masini L et al (2007) Antenatal post-hemorrhagic ventriculomegaly: a prospective follow-up study. Neuropediatrics 38:137–142
Martínez-Lage F, Pérez-Espejo MA, Almagro MJ et al (2005) Syndromes of overdrainage of ventricular shunting in childhood hydrocephalus. Childs Nerv Syst 16:124–133 (Span)
Martínez-Lage JF, Almagro MJ, del Rincón IS et al (2008) Management of neonatal hydrocephalus: feasibility of use and safety of two programmable (Sophy and Polaris) valves. Childs Nerv Syst 24:549–556
Massimi L, Di Rocco C (2013) Surgical treatment of posthemorrhagic infantile hydrocephalus. Minerva Pediatr 65:417–425
Massimi L, Paternoster G, Fasano T, Di Rocco C (2009) On the changing epidemiology of hydrocephalus. Childs Nerv Syst 25:795–800
Mazzola CA, Choudhri AF, Auguste KI et al (2014) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: management of posthemorrhagic hydrocephalus in premature infants. J Neurosurg Pediatr (Suppl) 14:8–23
Ment LR, Bada HS, Barnes P et al (2002) Practice parameter: neuroimaging in the neonate. Report of the quality standards subcommittee of the American Academy of Neurology and the practice committee of the Child Neurology Society. Neurology 58:1726–1738
Miranda P (2010) Intraventricular hemorrhage and posthemorrhagic hydrocephalus in the preterm infant. Minerva Pediatr 62:79–89
Morioka T, Hashiguchi K, Nagata S et al (2006) Fetal germinal matrix and intraventricular hemorrhage. Pediatr Neurosurg 42:354–361
Murphy BP, Inder TE, Rooks V et al (2002) Posthaemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome. Arch Dis Child Fetal Neonatal Ed 87:F37–F41
Reinprecht A, Dietrich W, Berger A et al (2001) Posthemorrhagic hydrocephalus in preterm infants: long–term follow-up and shunt-related complications. Childs Nerv Syst 17:663–669
Robinson S (2012) Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts. J Neurosurg Pediatr 9:242–258
Romero L, Ros B, Rius F et al (2014) Ventriculoperitoneal shunt as a primary neurosurgical procedure in newborn posthemorrhagic hydrocephalus: report of a series of 47 shunted patients. Childs Nerv Syst 30:91–97
Schulz M, Bührer C, Pohl-Schickinger A et al (2014) Neuroendoscopic lavage for the treatment of intraventricular hemorrhage and hydrocephalus in neonates. J Neurosurg Pediatr 13:626–635
Sirgiovanni I, Avignone S, Groppo M et al (2014) Intracranial haemorrhage: an incidental finding at magnetic resonance imaging in a cohort of late preterm and term infants. Pediatr Radiol 44:289–296
Stone SSD, Warf BC (2014) Combined endoscopic third ventriculostomyand choroid plexus cauterization as primary treatment for infant hydrocephalus. A prospective North American series. J Neurosurg Pediatr 14:439–446
Tortorolo G, Luciano R, Papacci P, Tonelli T (1999) Intraventricular hemorrhage: past, present and future, focusing on classification, pathogenesis and prevention. Childs Nerv Syst 15:652–661
Tröbs RB, Sander V (2015) Posthemorrhagic hydrocephalus in extremely low birth weight infants: Ommaya reservoir vs. ventriculoperitoneal shunt. Childs Nerv Syst 31:1261–1266
Tsitouras V, Sgouros S (2011) Infantile posthemorrhagic hydrocephalus. Childs Nerv Syst 27:1595–1608
Tubbs RS, Banks JT, Soleau S et al (2005) Complications of ventriculosubgaleal shunts in infants and children. Childs Nerv Syst 21:48–51
Vasileiadis GT, Gelman N, Han VKM et al (2004) Uncomplicated intraventricular hemorrhage is followed by reduced cortical volume at near-term age. Pediatrics 114:e367–e372
Vinchon M, Baroncini M, Delestret I (2012) Adult outcome of pediatric hydrocephalus. Childs Nerv Syst 28:847–854
Wang JY, Ahn ES (2015) Posthemorrhagic and postinfectious complications. In: Di Rocco C, Turgut M, Jallo G, Martínez-Lage JF (eds) Complications of CSF shunting in hydrocephalus. Springer, Heidelberg/Dordrecht/London/New York, pp 149–158
Warf BC, Campbell JW, Riddle E (2011) Initial experience with combined endoscopic third ventriculostomy and choroid plexus cauterization for posthemorrhagic hydrocephalus of prematurity: the importance of prepontine cistern status and the predictive value of FIESTA MRI imaging. Childs Nerv Syst 27:1063–1071
Wellons JC III, Shannon CN, Kulkarni AV et al (2009) A multicenter retrospective comparison of conversion from temporary to permanent cerebrospinal fluid diversion in very low birth weight infants with posthemorrhagic hydrocephalus. J Neurosurg Pediatr 4:50–55
Wellons JC III, Holubkov R, Browd SR et al (2013) The assessment of bulging fontanel and splitting of sutures in premature infants: an interrater reliability study by the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr 11:12–14
Whitelaw A, Rivers RPA, Creighton L, Gaffney P (1992) Low dose intraventricular fibrinolytic treatment to prevent posthaemorrhagic hydrocephalus. Arch Dis Child 67:12–14
Whitelaw A, Saliba E, Fellman V et al (1996) Phase I study of recombinant tissue plasminogen activator for treatment of posthaemorrhagic hydrocephalus. Arch Dis Child 75:F20–F26
WHO (2012) Born too soon: the global action report on preterm birth. http://www.who.int/pmnch/media/news/2012/201204_borntoosoon-report.pdf. Accessed 10 May 2016
WHO (2015) WHO recommentations on interventions to improve preterm birth outcomes http://apps.who.int/iris/bitstream/10665/183037/1/9789241508988_eng.pdf?ua=1. Accessed 27 June 2017
Williams MA, McAllister JP, Walker ML (2007) Priorities for hydrocephalus research: report from National Institutes of Health-sponsored workshop. J Neurosurg Pediatr 107(5 Suppl):345–357
Zhu X, Di Rocco C (2013) Choroid plexus coagulation for hydrocephalus not due to CSF overproduction: a review. Childs Nerv Syst 29:35–42
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Martínez-Lage, J.F., López-Guerrero, A.L., Almagro, MJ. (2017). Posthemorrhagic Hydrocephalus. In: Di Rocco, C., Pang, D., Rutka, J. (eds) Textbook of Pediatric Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-31512-6_17-1
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DOI: https://doi.org/10.1007/978-3-319-31512-6_17-1
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Posthemorrhagic Hydrocephalus- Published:
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DOI: https://doi.org/10.1007/978-3-319-31512-6_17-2
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Posthemorrhagic Hydrocephalus- Published:
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DOI: https://doi.org/10.1007/978-3-319-31512-6_17-1