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Mechanisms of Cardiac Cell Death

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Cardiomyocytes – Active Players in Cardiac Disease

Abstract

As cardiomyocytes build up the contractile machinery of the heart, every loss of cardiomyocytes in diverse cardiac diseases inevitably weakens the contractile power of the heart. Therefore, prevention of cardiomyocyte death should be one of the major aims when thinking about cardioprotection. As cell death can take different forms that are induced by various stressors and that proceed via different pathways, it is necessary to strictly differentiate between these kinds of death in order to find optimised ways of therapy. In this chapter, we will introduce necrosis, apoptosis, necroptosis and the death-related process of autophagy as the different kinds of cell death occurring in cardiomyocytes. The triggers of cardiomyocyte death and the contribution of different kinds of cell death to cardiac diseases, with a special focus on ischemia/reperfusion injury and heart failure progression, will be presented.

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  1. Institute of Physiology, Justus Liebig University, Aulweg 129, 35392, Giessen, Germany

    Gerhild Euler

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  1. Institute of Physiology, Justus-Liebig-Universität Giessen, Giessen, Hessen, Germany

    Klaus-Dieter Schlüter

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Euler, G. (2016). Mechanisms of Cardiac Cell Death. In: Schlüter, KD. (eds) Cardiomyocytes – Active Players in Cardiac Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-31251-4_9

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