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2 Insight into Fungal Secondary Metabolism from Ten Years of LaeA Research

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Biochemistry and Molecular Biology

Part of the book series: The Mycota ((MYCOTA,volume III))

Abstract

In 2004, the protein LaeA was identified and characterized as a global regulator of secondary metabolism in the fungus Aspergillus nidulans. Since this initial report, LaeA has been further described as a member of the fungal-specific Velvet Complex, a transcriptional complex critical in linking morphological transitions with chemical output. Hence, LaeA and the other two members of the Velvet Complex, VeA and VelB, are not only key regulators of secondary metabolite production but also asexual and sexual spore production. All three proteins are conserved in the Ascomycetes and possibly in the Basidiomycetes. Here, we will focus on LaeA-led studies contributing to our knowledge of regulation and synthesis of secondary metabolites in fungi.

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Acknowledgements

This work was funded by NIH 1 R01 Al065728-01 and NIH P01 GM084077 to N.P.K.

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  1. Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA

    Jin Woo Bok & Nancy P. Keller

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  1. Jin Woo Bok
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Correspondence to Jin Woo Bok .

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  1. Pharmazeutische Mikrobiologie, Friedrich-Schiller-Universität, Jena, Germany

    Dirk Hoffmeister

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Bok, J.W., Keller, N.P. (2016). 2 Insight into Fungal Secondary Metabolism from Ten Years of LaeA Research. In: Hoffmeister, D. (eds) Biochemistry and Molecular Biology. The Mycota, vol III. Springer, Cham. https://doi.org/10.1007/978-3-319-27790-5_2

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