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Nonclassical Pharmacodynamics

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Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Part of the book series: Interdisciplinary Applied Mathematics ((IAM,volume 30 ))

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Abstract

Whereas the concentration of a drug depends on the administration protocol and on intrinsic pharmacokinetic characteristics of the process, endogenous substances are certainly regulated by appropriate internal control mechanisms. For example, the neurotransmitter norepinephrine is released from sympathetic nerve endings and its concentration is regulated by enzymes and by a mechanism for reuptake of this catecholamine into nerve endings. Deficiencies in the control of such important chemicals may result in vasospasm, spasticity, and a variety of behavioral abnormalities. Such observations strongly suggest the existence of control systems represented by negative feedback mechanisms. By means of those mechanisms, the dynamic system controls the local concentration of critical endogenous chemicals that interact with receptors according to the mass-action

The whole is more than its parts.

Aristotle (384–322 BC)

Metaphysics

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Authors and Affiliations

  1. Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece

    Panos Macheras

  2. Faculty of Pharmacy, Aix-Marseille University, Marseille, France

    Athanassios Iliadis

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  1. Panos Macheras
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Macheras, P., Iliadis, A. (2016). Nonclassical Pharmacodynamics. In: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics. Interdisciplinary Applied Mathematics, vol 30 . Springer, Cham. https://doi.org/10.1007/978-3-319-27598-7_13

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