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Staging of Hepatocellular Carcinoma, Hepatoblastoma, and Cholangiocarcinomas

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract
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Abstract

Staging of hepatocellular carcinoma (HCC) and other hepatobiliary cancers is critical for optimal treatment and a complex task that depends on multiple factors, such as tumor extent at diagnosis and liver function. In recent years, several staging systems have been developed that have markedly improved the methods to arrive at optimal risk stratification procedures and the formulation of novel treatment approaches. However, still no single staging system is successfully applicable to any patient with hepatobiliary cancer. Apart from HCC, intricate and highly reproducible staging systems have been developed for extrahepatic cholangiocarcinoma, intrahepatic cholangiocarcinoma, and hepatoblastoma.

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References

  • Adam A, Benjamin IS (1992) The staging of cholangiocarcinoma. Clin Radiol 46:299–303

    Article  CAS  PubMed  Google Scholar 

  • Aronson DC, Schnater M, Staalman CR, Weverling GJ, Plaschkes J, Perilongo G et al (2005) Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of pediatric Oncology Liver Tumor Study Group SIOPEL-1 study. J Clin Oncol 23:1245–1252

    Article  PubMed  Google Scholar 

  • Bengmark S, Ekberg H, Evander A, Klofver-Stahl B, Tranberg KG (1988) Major liver resection for hilar cholangiocarcinoma. Ann Surg 207:120–125

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bismuth H, Corlette MB (1975) Intrahepatic cholangioenteric anastomosis in carcinoma of the hilus of the liver. Surg Gynecol Obstet 140:170–178

    CAS  PubMed  Google Scholar 

  • Blechacz BR, Sanchez W, Gores GJ (2009) A conceptual proposal for staging ductal cholangiocarcinoma. Curr Opin Gastroenterol 25:238–239

    Article  PubMed  PubMed Central  Google Scholar 

  • Blechacz B, Komuta M, Roskams T, Gores GJ (2011) Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol 8:512–522

    Article  PubMed  PubMed Central  Google Scholar 

  • Bolondi L, Burroughs A, Dufour JF, Galle PR, Mazzaferro V, Piscaglia F, Raoul JL et al (2012) Heterogeneity of patients with intermediate (BCLC B) hepatocellular carcinoma: proposal for a subclassification to facilitate treatment decisions. Semin Liver Dis 32:348–359

    CAS  PubMed  Google Scholar 

  • Burns JM, Greene FL (2005) Controversies in staging of hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 12:456–462

    Article  PubMed  Google Scholar 

  • Chan AC, Fan ST, Poon RT, Cheung TT, Chok KS, Chan SC, Lo CM (2013) Evaluation of the seventh edition of the American Joint Committee on cancer tumour-node-metastasis (TNM) staging system for patients undergoing curative resection of hepatocellular carcinoma: implications for the development of a refined staging system. HPB (Oxford) 15:439–448

    Article  Google Scholar 

  • Cheng CH, Lee CF, Wu TH, Chan KM, Chou HS, Wu TJ, Yu MC, Chen TC, Lee WC et al (2011) Evaluation of the new AJCC staging system for resectable hepatocellular carcinoma. World J Surg Oncol 9:114

    Article  PubMed  PubMed Central  Google Scholar 

  • Chevret S, Trinchet JC, Mathieu D, Rached AA, Beaugrand M, Chastang C (1999) A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d’Etude et de Traitement du Carcinoma Hépatocellulaire. J Hepatol 31:133–141

    Article  CAS  PubMed  Google Scholar 

  • Choi SB, Kim KS, Choi JY, Park SW, Choi JS, Lee WJ, Chung JB (2009) The prognosis and survival outcome of intrahepatic cholangiocarcinoma following surgical resection: association of lymph node metastasis and lymph node dissection with survival. Ann Surg Oncol 16:3048–3056

    Article  PubMed  Google Scholar 

  • Chun YH, Ahn SH (2011) Prognostic value of the 7th edition of the AJCC staging system as a clinical staging system in patients with hepatocellular carcinoma. Eur J Cancer 47:2568–2575

    Article  PubMed  Google Scholar 

  • Chun JM, Kwon HJ, Sohn J, Kim SG, Park JY, Bae HI, Yun YK, Hwang YJ (2011) Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma. J Surg Oncol 103:148–151

    Article  PubMed  Google Scholar 

  • Chung YE, Kim MJ, Park YN, Lee YH, Choi JY (2008) Staging of extrahepatic cholangiocarcinoma. Eur Radiol 18:2182–2195

    Article  PubMed  Google Scholar 

  • Cillo U, Vitale A, Grigoletto F, Farinati F, Brolese A, Zanus G, Neri D, Boccagni P et al (2006) Prospective validation of the Barcelona Clinic Liver Cancer staging system. J Hepatol 44:723–731

    Article  PubMed  Google Scholar 

  • DeOliveira ML, Schulick RD, Nimura Y, Rosen C, Gores G, Neuhaus P, Clavien PA (2011) New staging system and a registry for perihilar cholangiocarcinoma. Hepatology 53:1363–1371

    Article  PubMed  Google Scholar 

  • Ebata T, Nagino M, Nishio H, Igami T, Yokoyama Y, Nimura Y (2007) Pancreatic and duodenal invasion in distal bile duct cancer: paradox in the tumor classification of the American Joint Committee on Cancer. World J Surg 31:2008–2015

    Article  PubMed  Google Scholar 

  • Edge SB (2009) American Joint Committee on Cancer: AJCC cancer staging manual, 7th edn. Springer, New York

    Google Scholar 

  • Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (eds) (2010) AJCC cancer staging manual, 7th edn. Springer, New York

    Google Scholar 

  • Endo I, Gonen M, Yopp AC, Dalal KM, Zhou Q, Klimstra D, D’Angelica M, DeMatteo RP et al (2008) Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg 248:84–96

    Article  PubMed  Google Scholar 

  • Farges O, Fuks D, Le Treut YP, Azoulay D, Laurent A, Bachellier P, Nuzzo G, Belghiti J et al (2011) AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: by the AFC-IHCC-2009 study group. Cancer 117:2170–2177

    Article  PubMed  Google Scholar 

  • Hasebe T, Konishi M, Iwasaki M, Nakagohri T, Takahashi SI, Gotohda N, Kinoshita T, Ochiai A (2008) Primary tumor/vessel tumor/nodal tumor classification of extrahepatic bile duct carcinoma. Hum Pathol 39:37–48

    Article  PubMed  Google Scholar 

  • Hiriart JB, Laurent C, Blanc JF (2011) Perihilar cholangiocarcinoma, the need for a new staging system. Clin Res Hepatol Gastroenterol 35:697–698

    Article  PubMed  Google Scholar 

  • Hong SM, Kang GH, Lee HY, Ro JY (2000) Smooth muscle distribution in the extrahepatic bile duct: histologic and immunohistochemical studies of 122 cases. Am J Surg Pathol 24:660–667

    Article  CAS  PubMed  Google Scholar 

  • Hsu CY, Huang YH, Hsia CY, Su CW, Lin HC, Loong CC, Chiou YY, Chiang JH et al (2010) A new prognostic model for hepatocellular carcinoma based on total tumor volume: the Taipei Integrated Scoring System. J Hepatol 53:108–117

    Article  PubMed  Google Scholar 

  • Huang YH, Chen CH, Chang TT, Chen SC, Wang SY, Lee HS, Lin PW, Huang GT et al (2005) Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery. J Gastroenterol Hepatol 20:765–771

    Article  PubMed  Google Scholar 

  • Huang J, Zhang Y, Peng Z, Gao H, Xu L, Jiao LR, Chen M (2013) A modified TNM-7 staging system to better predict the survival in patients with hepatocellular carcinoma after hepatectomy. J Cancer Res Clin Oncol 139:1709–1719

    Article  CAS  PubMed  Google Scholar 

  • Huo TI, Huang YH, Lin HC, Wu JC, Chiang JH, Lee PC, Chang FY, Lee SD (2006) Proposal of a modified Cancer of the Liver Italian Program staging system based on the model for end-stage liver disease for patients with hepatocellular carcinoma undergoing loco-regional therapy. Am J Gastroenterol 101:975–982

    Article  PubMed  Google Scholar 

  • Igami T, Ebata T, Yokoyama Y, Sugawara G, Takahashi Y, Nagino M (2011) Staging of peripheral-type intrahepatic cholangiocarcinoma: appraisal of the new TNM classification and its modifications. World J Surg 35:2501–2509

    Article  PubMed  Google Scholar 

  • Japanese Society of Biliary Surgery (1997) General rules for surgical and pathological studies on cancer of biliary tract, 4th edn. Kanehara, Tokyo

    Google Scholar 

  • Jarnagin WR (2000) Cholangiocarcinoma of the extrahepatic bile ducts. Semin Surg Oncol 19:156–176

    Article  CAS  PubMed  Google Scholar 

  • Jarnagin WR, Fong Y, DeMatteo RP, Gonen M, Burke EC, Bodniewicz BS et al (2001) Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg 234:507–519

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Juntermanns B, Sotiropoulos GC, Radunz S, Reis H, Heuer M, Baba HA, Canbay A et al (2013) Comparison of the sixth and the seventh editions of the UICC classification for perihilar cholangiocarcinoma. Ann Surg Oncol 20:277–284

    Article  PubMed  Google Scholar 

  • Kaseb AO, Morris JS, Hassan MM, Siddiqui AM, Lin E, Xiao L, Abdalla EK, Vauthey JN et al (2011a) Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. J Clin Oncol 29:3892–3899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaseb AO, Abbruzzese JL, Vauthey JN, Aloia TA, Abdalla EK, Hassan MM, Lin E et al (2011b) I-CLIP: improved stratification of advanced hepatocellular carcinoma patients by integrating plasma IGF-1 into CLIP score. Oncology 80:373–381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kee KM, Wang JH, Lee CM, Chen CL, Changchien CS, Hu TH, Cheng YF, Hsu HC et al (2007) Validation of clinical AJCC/UICC TNM staging system for hepatocellular carcinoma: analysis of 5,613 cases from a medical center in southern Taiwan. Int J Cancer 120:2650–2655

    Article  CAS  PubMed  Google Scholar 

  • Kim HJ (2005) TNM staging of hilar cholangiocarcinoma (in Korean). Korean J Gastroenterol 46:20–27

    PubMed  Google Scholar 

  • Kim BK, Kim SU, Park JY, Kim do Y, Ahn SH, Park MS, Kim EH, Seong J, Lee do Y et al (2012) Applicability of BCLC stage for prognostic stratification in comparison with other staging systems: single centre experience from long-term clinical outcomes of 1717 treatment-naïve patients with hepatocellular carcinoma. Liver Int 32:1120–1127

    Article  CAS  PubMed  Google Scholar 

  • Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K, Fushiya N, Koike K, Nishino H et al (2013) The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma. BMC Cancer 13:52

    Article  PubMed  PubMed Central  Google Scholar 

  • Kitagawa Y, Nagino M, Kamiya J, Uesaka K, Sano T, Yamamoto H, Hayakawa N, Nimura Y (2001) Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg 233:385–392

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koerkamp BG, Wiggers JK, Allen PJ, Busch OR, D’Angelica MI, DeMatteo RP, Fong Y et al (2014) American Joint Committee on Cancer staging for resected perihilar cholangiocarcinoma: a comparison of the 6th and 7th editions. HPB (Oxford) 16:1074–1082

    Article  Google Scholar 

  • Kokudo N, Arita J (2010) Staging for intrahepatic cholangiocarcinoma. Liver Int 30:931–933

    Article  PubMed  Google Scholar 

  • Kudo M, Chung H, Osaki Y (2003) Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score). J Gastroenterol 38:207–215

    Article  PubMed  Google Scholar 

  • Kudo M, Chung H, Haji S, Osaki Y, Oka H, Seki T, Kasugai H, Sasaki Y, Matsunaga T (2004) Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score. Hepatology 40:1396–1405

    Article  PubMed  Google Scholar 

  • Leung TW, Tang AM, Zee B, Lau WY, Lai PB, Leung KL, Lau JT, Yu SC, Johnson PJ (2002) Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients. Cancer 94:1760–1769

    Article  PubMed  Google Scholar 

  • Li X, Dong M, Lin Q, Chen ZH, Ma XK, Xing YF, Wan XB, Wen JY, Wei L, Chen J et al (2013) Comparison of current staging systems for advanced hepatocellular carcinoma not amendable to locoregional therapy as inclusion criteria for clinical trials. Asia Pac J Clin Oncol 9:86–92

    Article  PubMed  Google Scholar 

  • Liver Cancer Study Group of Japan (1997) Clinical and surgical findings. In: Liver Cancer Study Group of Japan (ed) Classification of primary liver cancer. First English edition. Kanehara Shuppan, Toyko, pp 1–22

    Google Scholar 

  • Llovet JM, Bru C, Bruix J (1999) Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 19:329–338

    Article  CAS  PubMed  Google Scholar 

  • Maida M, Orlando E, Camma C, Cabibbo G (2014) Staging systems of hepatocellular carcinoma: a review of literature. World J Gastroenterol 20:4141–4150

    Article  PubMed  PubMed Central  Google Scholar 

  • Marrero JA, Fontana RJ, Barrat A, Askari F, Conjeevaram HS, Su GL, Lok AS (2005) Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort. Hepatology 41:707–716

    Article  PubMed  Google Scholar 

  • Matsuo K, Rocha FG, Ito K, D’Angelica MI, Allen PJ, Fong Y, Dematteo RP, Gonen M et al (2012) The Blumgart preoperative staging system for hilar cholangiocarcinoma: analysis of resectability and outcomes in 380 patients. J Am Coll Surg 215:343–355

    Article  PubMed  Google Scholar 

  • McCarville MB, Roebuck DJ (2012) Diagnosis and staging of hepatoblastoma: imaging aspects. Pediatr Blood Cancer 59:793–799

    Article  PubMed  Google Scholar 

  • Meyers RL, Katzenstein HM, Malogolowkin MH (2007) Predictive value of staging systems in hepatoblastoma. J Clin Oncol 25:737

    Article  PubMed  Google Scholar 

  • Meyers RL, Rowland JR, Krailo M, Chen Z, Katzenstein HM, Malogolowkin MH (2009) Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children’s Oncology Group. Pediatr Blood Cancer 53:1016–1022

    Article  PubMed  PubMed Central  Google Scholar 

  • Minagawa M, Ikai I, Matsuyama Y, Yamaoka Y, Makuuchi M (2007) Staging of hepatocellular carcinoma. Assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan. Ann Surg 245:909–922

    Article  PubMed  PubMed Central  Google Scholar 

  • Nagino M (2011) Perihilar cholangiocarcinoma: a much needed but imperfect new staging system. Nat Rev Gastroenterol Hepatol 8:252–253

    PubMed  Google Scholar 

  • Nanashima et al. (2006) http://www.ncbi.nlm.nih.gov/pubmed/16699859

  • Nathan H, Pawlik TM (2010) Staging of intrahepatic cholangiocarcinoma. Curr Opin Gastroenterol 26:269–273

    Article  CAS  PubMed  Google Scholar 

  • Nathan H, Aloia TA, Vauthey JN, Abdalla EK, Zhu AX, Schulick RD, Choti MA et al (2009) A proposed staging system for intrahepatic cholangiocarcinoma. Ann Surg Oncol 16:14–22

    Article  PubMed  Google Scholar 

  • Nishi M, Omori Y, Miwa K (1998) Japanese Research Society for Gastric Cancer (JRSGC): Japanese classification of gastric carcinoma. Kanehara, Tokyo

    Google Scholar 

  • Nishio H, Nagino M, Oda K, Ebata T, Arai T, Nimura Y (2005) TNM classification for perihilar cholangiocarcinoma: comparison between 5th and 6th editions of the AJCC/UICC staging system. Langenbecks Arch Surg 390:319–327

    Article  PubMed  Google Scholar 

  • No authors (1998) A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology 28:751–755

    Google Scholar 

  • Okabayashi T, Yamamoto J, Kosuge T, Shimada K, Yamasaki S, Takayama T, Makuuchi M (2001) A new staging system for mass-forming intrahepatic cholangiocarcinoma: analysis of preoperative and postoperative variables. Cancer 92:2374–2383

    Article  CAS  PubMed  Google Scholar 

  • Okuda K, Ohtsuki T, Obata H, Tamimatsu M, Okazaki N, Hasegawa H et al (1985) Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 56:918–928

    Article  CAS  PubMed  Google Scholar 

  • Omagari K, Honda S, Kadokawa Y, Isomoto H, Takeshima F, Hayashida K, Mizuta Y et al (2004) preliminary analysis of a newly proposed prognostic scoring system (SLiDe score) for hepatocellular carcinoma. J Gastroenterol Hepatol 19:805–811

    Article  PubMed  Google Scholar 

  • Paul A, Kaiser GM, Molmenti EP, Schroeder T, Venadakis S, Oezcelik A, Baba HA et al (2011) Klatskin tumors and the accuracy of the Bismuth-Corlette classification. Am Surg 77:1695–1699

    PubMed  Google Scholar 

  • Pinato DJ, Stebbing J, Ishizuka M, Khan SA, Wasan HS, North BV, Kubota K, Sharma R (2012) A novel and validated prognostic index in hepatocellular carcinoma: the inflammation based index (IBI). J Hepatol 57:1013–1020

    Article  PubMed  Google Scholar 

  • Pons F, Varela M, Llovet JM (2005) Staging systems in hepatocellular carcinoma. HPB (Oxford) 7:35–41

    Article  Google Scholar 

  • Ribero D, Nuzzo G, Amisano M, Tomatis M, Guglielmi A, Giulini SM, Aldrighetti L et al (2011) Comparison of the prognostic accuracy of the sixth and seventh editions of the TNM classification for intrahepatic cholangiocarcinoma. HPB (Oxford) 13:198–205

    Article  Google Scholar 

  • Roebuck DJ, Olsen O, Pariente D (2006) Radiological staging in children with hepatoblastoma. Pediatr Radiol 36:176–182

    Article  PubMed  Google Scholar 

  • Roebuck DJ, Aronson D, Clapuyt P, Czauderna P, de Ville de Goyet J, Gauthier F et al (2007a) 2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group. Pediatr Radiol 37:123–132

    Article  PubMed  Google Scholar 

  • Roebuck DJ, Sebire NJ, Pariente D (2007b) Assessment of extrahepatic abdominal extension in primary malignant liver tumours of childhood. Pediatr Radiol 37:1096–1100

    Article  PubMed  Google Scholar 

  • Shen WF, Zhong W, Xu F, Kan T, Geng L, Xie F, Sui CJ, Yang JM (2009) Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma. World J Gastroenterol 15:5976–5982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sobin LH, Wittekin C (1997) UICC TNM classification of malignant tumors, 5th edn. Wiley-Liss, New York

    Google Scholar 

  • Sobin LH, Gospodarowicz MK, Wittekind C (2009a) International union against cancer (UICC) TNM classification of malignant tumours, 7th edn. Wiley, New York

    Google Scholar 

  • Sobin LH, Gospodarowicz MK, Wittekind C (eds) (2009b) TNM classification of malignant tumours, 7th edn. UICC, International Union against Cancer, Wiley-Blackwell, Oxford

    Google Scholar 

  • Tateishi R, Yoshida H, Shiina S, Imamura H, Hasegawa K, Teratani T, Obi S, Sato S et al (2005) Proposal of a new prognostic model for hepatocellular carcinoma: an analysis of 403 patients. Gut 54:419–425

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tsunoda T, Eto T, Koga M, Tomioka T, Motoshima K, Yamaguchi T, Izawa K, Tsuchiya R (1989) Early carcinoma of the extrahepatic bile duct. Jpn J Surg 19:691–698

    Article  CAS  PubMed  Google Scholar 

  • Uchiyama K, Yamamoto M, Yamaue H, Ariizumi S, Aoki T, Kokudo N, Ebata T, Nagino M et al (2011) Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Surg 18:443–452

    Article  Google Scholar 

  • Uenishi T, Yamazaki O, Yamamoto T, Hirohashi K, Tanaka H, Tanaka S, Hai S, Kubo S (2005) Serosal invasion in TNM staging of mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 12:479–483

    Article  PubMed  Google Scholar 

  • Uenishi T, Ariizumi S, Aoki T, Ebata T, Ohtsuka M, Tanaka E, Yoshida H, Imura S et al (2014) Proposal of a new staging system for mass-forming intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci 21:499–508

    Article  PubMed  Google Scholar 

  • Vauthey JN, Lauwers GY, Esnaola NF, Do KA, Belghiti J, Mirza N, Curley SA, Ellis LM et al (2002) Simplified staging for hepatocellular carcinoma. J Clin Oncol 20:1527–1536

    Article  PubMed  Google Scholar 

  • Vauthey JN, Dixon E, Abdalla EK, Helton WS, Pawlik TM, Taouli B, Brouquet A et al (2010) Pretreatment assessment of hepatocellular carcinoma: expert consensus statement. HPB (Oxford) 12:289–299

    Article  Google Scholar 

  • Vitale et al. (2011) http://www.ncbi.nlm.nih.gov/pubmed/21912636

  • Washington MK, Berlin J, Branton PA, Burgart LJ, Carter DK, Compton CC, Fitzgibbons PL et al (2010) Protocol for the examination of specimens from patients with carcinoma of the distal extrahepatic bile ducts. Arch Pathol Lab Med 134:e8–e13

    PubMed  Google Scholar 

  • Weber SM, Jarnagin WR, Klimstra D, DeMatteo RP, Fong Y, Blumgart LH (2001) Intrahepatic cholangiocarcinoma: resectability, recurrence pattern, and outcomes. J Am Coll Surg 193:384–391

    Article  CAS  PubMed  Google Scholar 

  • Yamasaki S (2003) Intrahepatic cholangiocarcinoma: macroscopic type and stage classification. J Hepatobiliary Pancreat Surg 10:288–291

    Article  PubMed  Google Scholar 

  • Yau T, Tang VY, Yao TJ, Fan ST, Lo CM, Poon RT (2014) Development of Hong Kong Liver Cancer Staging System with treatment stratification for patients with hepatocellular carcinoma. Gastroenterology 146:1691–1700

    Article  PubMed  Google Scholar 

  • Yi J, Gwak GY, Sinn DH, Kim YJ, Kim HN, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC (2013) Screening for extrahepatic metastases by additional staging modalities is required for hepatocellular carcinoma patients beyond modified UICC stage T1. Hepatogastroenterology 60:328–332

    CAS  PubMed  Google Scholar 

  • Zhang JF, Shu ZJ, Xie CY, Li Q, Jin XH, Gu W, Jiang FJ, Ling CQ (2014) Prognosis of unresectable hepatocellular carcinoma: comparison of seven staging systems (TNM, Okuda, BCLC, CLIP, CUOPI, JIS, CIS) in a Chinese cohort. PLoS One 9:e88182

    Article  PubMed  PubMed Central  Google Scholar 

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Zimmermann, A. (2017). Staging of Hepatocellular Carcinoma, Hepatoblastoma, and Cholangiocarcinomas. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_188

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