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Gallbladder Carcinomas Not Related to Glandular Epithelia

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

In addition to the common glandular carcinomas (adenocarcinoma) of the gallbladder, few other types of carcinoma can develop in this organ. Squamous cell carcinoma is a rare type of gallbladder malignancy clinically characterized by a more rapid and aggressive growth with infiltration of the liver and adjacent organs, but less frequent lymph node metastases in comparison with adenocarcinoma. This tumor accounts for only few percent of all gallbladder cancers. Macroscopically, squamous cell carcinoma usually produces large bulky lesions that efface the gallbladder wall. Adenosquamous carcinoma of the gallbladder is also rare and is diagnosed with an incidence similar to that of squamous cell carcinoma. Hepatoid carcinoma of the gallbladder is a rare variant of extrahepatic carcinoma which in several respects mimics hepatocellular carcinoma. Only few well-documented cases were reported for the gallbladder. These cancers are rapidly growing and highly aggressive lesions, similar to their counterparts in other organs. Very rare primary carcinomas of the gallbladder consist of small cells in the absence of neuroendocrine markers. Other very rare primary carcinomas of the gallbladder include anaplastic and pleomorphic carcinoma variants.

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    Arthur Zimmermann

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Zimmermann, A. (2017). Gallbladder Carcinomas Not Related to Glandular Epithelia. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_151

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