Abstract
Extraskeletal tumors containing multinucleated, osteoclast-like giant cells (OGCs) are uncommon. These neoplasms are most frequently reported in the breast and pancreas. Recently, some authors have suggested that carcinomas containing OGCs may represent a distinct clinicopathological entity with a more favorable prognosis. Occurrence in the gallbladder is extremely rare, with only one previous case. We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs. A 72-year-old woman presented with postprandial abdominal pain and was found to have a mass in the body of the gallbladder with direct liver invasion. Histological examination showed an adenosquamous carcinoma with an infiltrate of benign OGCs. Immunohistochemical analysis demonstrated that the giant cells were of histiocytic origin. The patient survived for 6 years without evidence of recurrence. This case adds to a small body of literature on gallbladder carcinoma with OGCs. Further studies are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma) with those cells.
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References
LM Gjerdrum MC Lauridsen FB Sorensen (2001) ArticleTitleBreast carcinoma with osteoclast-like giant cells: morphological and ultrastructural studies of a case with review of the literature Breast 10 231–6 Occurrence Handle10.1054/brst.2000.0244 Occurrence Handle1:STN:280:DC%2BD2c%2Fns1Chtg%3D%3D Occurrence Handle14965590
O Dworak C Wittekind HP Koerfgen FP Gall (1993) ArticleTitleOsteoclastic giant cell tumor of the pancreas. An immunohistological study and review of the literature Pathol Res Pract 189 228–31 Occurrence Handle1:STN:280:ByyA3M%2FhtlE%3D Occurrence Handle8321752
V Stracca-Pansa A Menegon PM Donisi L Bozzola F Fedeli F Quarto et al. (1995) ArticleTitleGastric carcinoma with osteoclast-like giant cells. Report of four cases Am J Clin Pathol 103 453–9 Occurrence Handle1:STN:280:ByqB2czitVA%3D Occurrence Handle7726143
DY Baschinsky WL Frankel TH Niemann (1999) ArticleTitleGastric carcinoma with osteoclast-like giant cells Am J Gastroenterol 94 1678–81 Occurrence Handle10.1111/j.1572-0241.1999.01162.x Occurrence Handle1:STN:280:DyaK1M3ptVOisA%3D%3D Occurrence Handle10364044
M Odeh I Misselevich A Oliven JH Boss (1995) ArticleTitleSmall intestinal carcinoma with osteoclast-like giant cells Am J Gastroenterol 90 1177–9 Occurrence Handle1:STN:280:ByqA3srmtFQ%3D Occurrence Handle7611227
T Ikeda S Seki M Maki N Noguchi T Kawamura S Arii et al. (2003) ArticleTitleHepatocellular carcinoma with osteoclast-like giant cells: possibility of osteoclastogenesis by hepatocyte-derived cells Pathol Int 53 450–6 Occurrence Handle12828610
LE Grosso JG Gonzalez (1992) ArticleTitleStromal osteoclast-like giant cells in an adenosquamous carcinoma of the gallbladder Hum Pathol 23 703–6 Occurrence Handle10.1016/0046-8177(92)90328-Z Occurrence Handle1:STN:280:By2B2srmtVY%3D Occurrence Handle1592394
InstitutionalAuthorNameJapanese Society of Biliary Surgery (2001) Classification of biliary tract carcinoma EditionNumberFirst English edition Kanehara Tokyo 34–50
N Udagawa N Takahashi T Akatsu H Tanaka T Sasaki T Nishihara et al. (1990) ArticleTitleOrigin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells Proc Natl Acad Sci U S A 87 7260–4 Occurrence Handle1:STN:280:By%2BA1cvpvVM%3D Occurrence Handle2169622
T Akatsu N Takahashi N Udagawa K Sato N Nagata JM Moseley et al. (1989) ArticleTitleParathyroid hormone (PTH)-related protein is a potent stimulator of osteoclast-like multinucleated cell formation to the same extent as PTH in mouse marrow cultures Endocrinology 125 20–7 Occurrence Handle1:CAS:528:DyaL1MXltV2nsrY%3D Occurrence Handle2544401
KJ Guo K Yamaguchi M Enjoji (1988) ArticleTitleUndifferentiated carcinoma of the gallbladder. A clinicopathologic, histochemical, and immunohistochemical study of 21 patients with a poor prognosis Cancer 61 1872–9 Occurrence Handle1:STN:280:BieC1cvltVw%3D Occurrence Handle2451557
J Albores-Saavedra H Cruz-Ortiz A Alcantara-Vazques DE Henson (1981) ArticleTitleUnusual types of gallbladder carcinoma. A report of 16 cases Arch Pathol Lab Med 105 287–93 Occurrence Handle1:STN:280:Bi6B3cnksVE%3D Occurrence Handle6263212
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Akatsu, T., Kameyama, K., Kawachi, S. et al. Gallbladder carcinoma with osteoclast-like giant cells. J Gastroenterol 41, 83–87 (2006). https://doi.org/10.1007/s00535-005-1726-5
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DOI: https://doi.org/10.1007/s00535-005-1726-5