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Phospholemman: A Brief Overview

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Regulation of Membrane Na+-K+ ATPase

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 15))

Abstract

Na+/K+-ATPase (NKA) plays the key role in maintaining Na+ and K+ gradients in cells, which is essential for regulation of cell volume and membrane potential. PLM (aka FXYD1) interacts with NKA and Na+/Ca2+ exchanger (NCX) and modulates their activities in tissue specific and physiological state specific manner. Protein kinase A (PKA) and protein kinase C (PKC) targets different pools of PLM associated with NKA and NCX, thereby regulating their activities. Additionally, some signal transducers such as phosphatases, phosphodiesterases and nitric oxide play important roles in modulating functions of PLM, especially under phosphorylated conditions, toward the activities of NKA and NCX. Understanding the above phenomenon is of significance in developing novel therapeutics for recovery of patients suffering from a variety of pathophysiological conditions, especially cardiovascular and neural diseases.

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Acknowledgement

Financial assistance from the Council of Scientific and Industrial Research (CSIR), Govt. of India and the DST-PURSE programme of the University of Kalyani (West Bengal, India) is greatly acknowledged.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, 741235, West Bengal, India

    Sajal Chakraborti, Md Nur Alam, Jaganmay Sarkar & Tapati Chakraborti

  2. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

    Kuntal Dey

  3. Department of Physiology, University of Arizona, Tucson, AZ, USA

    Amritlal Mandal

Authors
  1. Sajal Chakraborti
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  2. Kuntal Dey
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  3. Md Nur Alam
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  4. Amritlal Mandal
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  5. Jaganmay Sarkar
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  6. Tapati Chakraborti
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Correspondence to Sajal Chakraborti .

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Editors and Affiliations

  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Chakraborti, S., Dey, K., Alam, M.N., Mandal, A., Sarkar, J., Chakraborti, T. (2016). Phospholemman: A Brief Overview. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Membrane Na+-K+ ATPase. Advances in Biochemistry in Health and Disease, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-24750-2_14

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