Abstract
In the last 15 years increasing evidence has been added on non-motor cerebellar functions. In 1998 Schmahmann and Sherman defined a new clinical entity, the “cerebellar cognitive affective syndrome” (also called Schmahmann’s syndrome). In 2011 Tedesco et al. characterized the cognitive profile of subjects affected by focal cerebellar damage. The most adversely affected functions in focal cerebellar damage are sequencing, language, executive function, and visuospatial abilities.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brunamonti E, Chiricozzi FR, Clausi S, Olivito G, Giusti MA, Molinari M, Ferraina S, Leggio M (2014) Cerebellar damage impairs executive control and monitoring of movement generation. PLoS One 9(1):e85997
Chiricozzi FR, Clausi S, Molinari M, Leggio MG (2008) Phonological short-term store impairment after cerebellar lesion: a single case study. Neuropsychologia 46:1940–1953
Cook M, Murdoch BE, Cahill L, Whelan BM (2004) Higher-level language deficits resulting from left primary cerebellar lesions. Aphasiology 18:771–784
Courchesne E, Allen G (1997) Prediction and preparation, fundamental functions of the cerebellum. Learn Mem 4:1–35
Fabbro F, Tavano A, Corti S, Bresolin N, De Fabritiis P, Borgatti R (2004) Longterm neuropsychological deficits after cerebellar infarctions in two young twins. Neuropsychologia 42:536–545
Gottwald B, Wilde B, Mihajlovic Z, Mehdorn HM (2004) Evidence for distinct cognitive deficits after focal cerebellar lesions. J Neurol Neurosurg Psychiatry 75:1524–1531
Grimaldi G, Manto M (2012) Topography of cerebellar deficits in humans. Cerebellum 11(2):336–351
Habas C (2010) Functional imaging of the deep cerebellar nuclei: a review. Cerebellum 9:22–28
Hokkanen LSK, Kauranen V, Roine RO, Salonen O, Kotila M (2006) Subtle cognitive deficits after cerebellar infarcts. Eur J Neurol 13:161–170
Leggio MG, Silveri MC, Petrosini L, Molinari M (2000) Phonological grouping is specifically affected in cerebellar patients: a verbal fluency stady. J Neurol Neurosurg Psychiatry 69:102–106
Leggio MG, Tedesco AM, Chiricozzi FR, Clausi S, Orisini A, Molinari M (2008) Cognitive sequencing impairment in patients with focal or atrofic cerebellar damage. Brain 131:1332–1343
Leggio MG, Chiricozzi FR, Clausi S, Tedesco AM, Molinari M (2011) The neuropsychological profile of cerebellar damage: the sequencing hypothesis. Cortex 47:137–144
Leiner HC, Leiner AL, Dow RS (1986) Does the cerebellum contribute to mental skills? Behav Neurosci 100:443–454
Middleton FA, Strick PL (1998) Cerebellar output: motor and cognitive channels. Trends Cogn Sci 2:348–354
Molinari M, Leggio MG (2007) Cerebellar information processing and visuospatial functions. Cerebellum 6:214–220
Molinari M, Leggio MG, Solida A, Corra R, Misciagna S, Silveri MC, Petrosini L (1997) Cerebellum and procedural learning: evidence from focal cerebellar lesions. Brain 120:1753–1762
Molinari M, Petrosini L, Misciagna S, Leggio MG (2004) Visuspatial abilities in cerebellar disorders. J Neurol Neurosurg Psychiatry 75:235–240
Molinari M, Chiricozzi FR, Clausi S, Tedesco AM, De Lisa M, Leggio MG (2008) Cerebellum and detection of sequences, from perception to cognition. Cerebellum 7:611–615
Schmahmann JD, Sherman JC (1998) The cerebellar cognitive affective syndrome. Brain 121:561–579
Schoch B, Dimitrova A, Gizewski ER, Timmann D (2006) Functional localization in the human cerebellum based on voxelwise statistical analysis: a study of 90 patients. Neuroimage 30:36–51
Scott RB, Stoodley CJ, Anslow P, Paul C, Stein JF, Sugden EM, Mitchell CD (2001) Lateralized cognitive deficits in children following cerebellar lesions. Dev Med Child Neurol 43:685–691
Stoodley CJ, Schmahmann JD (2009) Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 44:489–501
Stoodley CJ, Schmahmann JD (2010) Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46:831–844
Strick PL, Dum RP, Fiez JA (2009) Cerebellum and nonmotor function. Annu Rev Neurosci 32:413–434
Tarnecki R (2003) Responses of the red nucleus neurons to limb stimulation after cerebellar lesions. Cerebellum 2:96–100
Tedesco AM, Chiricozzi FR, Clausi S, Lupo M, Molinari M, Leggio MG (2011) The cerebellar cognitive profile. Brain 134(Pt 12):3672–3686
Timmann D, Brandauer B, Hermsdörfer J, Ilg W, Konczak J, Gerwig M, Gizewski ER, Schoch B (2008) Lesion-symptom mapping of the human cerebellum. Cerebellum 7:602–606
van Ettinger-Veenstra HM, Ragnehed M, Hällgren M, Karlsson T, Landtblom AM, Lundberg P, Engström M (2010) Right-hemispheric brain activation correlates to language performance. Neuroimage 49:3481–3488
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Leggio, M. (2016). Clinical Functional Topography in Cognition. In: Gruol, D., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-24551-5_53
Download citation
DOI: https://doi.org/10.1007/978-3-319-24551-5_53
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-24549-2
Online ISBN: 978-3-319-24551-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)