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Regenerative Cells in the Ageing Lung

  • Chapter
Stem Cells in the Lung

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Healthy ageing slowly transforms the structure, gas exchange efficiency, mechanical properties, immune functions, and stem-progenitor cells of the lung. Further, ageing alters the biological responses of the lung to injury, infection, and tissue resection. Regeneration of the lung can be reactivated by partial pneumonectomy (PNX), thus making PNX a unique and powerful model for the analysis of age-dependent regenerative mechanisms in the healthy lung. Specifically, the response to PNX manifests as compensatory growth and remarkable hyperplasia of stem-progenitor cells in the lung parenchyma and the formation of new alveoli by secondary septation akin to late development. Importantly, the abundance and proliferation potential of specific stem-progenitor cells in the PNX model are strikingly age dependent. This chapter focuses on important mechanisms of lung regeneration revealed by PNX that are thought to be vulnerable to healthy ageing and places those mechanisms in the context of chronic lung disease.

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Authors and Affiliations

  1. Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, Bldg 21, Room 102, 200 Westboro Road, North Grafton, MA, 01536, USA

    Andrew M. Hoffman

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  1. Andrew M. Hoffman
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Correspondence to Andrew M. Hoffman .

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  1. Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Victoria, Australia

    Ivan Bertoncello

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Hoffman, A.M. (2015). Regenerative Cells in the Ageing Lung. In: Bertoncello, I. (eds) Stem Cells in the Lung. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-21082-7_8

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