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From Autologous Flaps to Engineered Vascularized Grafts for Bone Regeneration

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Vascularization for Tissue Engineering and Regenerative Medicine

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

Abstract

Replacement of damaged or lost tissue typically relies on the availability of living, functional substitutes and the rapid development of a stable and efficient vascularization upon transplantation, in order to guarantee their survival. These requirements challenge current surgical reconstruction techniques in the clinical practice.

In the past decades, the field of tissue engineering has introduced the possibility to combine materials and living cells to generate functional substitutes, which can be tailored to specific requirements of the implantation site. At the same time, plastic and reconstructive surgery has developed a large armamentarium of grafting possibilities and flaps supporting vascularization of native tissues, especially through progress made in microsurgical techniques.

In this chapter, we describe advances in the two fields and discuss how the principles and techniques independently developed could be combined towards the prefabrication of vascularized tissues. The resulting paradigm of “regenerative surgery,” here exemplified in the specific context of bone regeneration, could represent the future standard for the reconstruction of complex body parts.

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Acknowledgments

This work was partially supported by The Swiss National Foundation (Grant number 310030_156291), The European Union, FP7 Marie Curie Actions (Project iTERM) and The Osteology Foundation (Project No. 13-059).

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Authors and Affiliations

  1. Department of Biomedicine, University Hospital Basel, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland

    Alexander Haumer, Arnaud Scherberich & Ivan Martin

  2. Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123, Allschwil, Switzerland

    Alexander Haumer, Arnaud Scherberich & Ivan Martin

  3. Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland

    Tarek Ismail, Alexander Lunger, Rik Osinga, Arnaud Scherberich & Dirk Johannes Schaefer

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  1. Alexander Haumer
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  1. AUVA Research Center, Ludwig Boltzmann Inst. Exp. a. Clinical AUVA Research Center, Wien, Holy See (Vatican City State)

    Wolfgang Holnthoner

  2. Department of Biomedicine, University Hospital Basel Department of Biomedicine, Basel, Switzerland

    Andrea Banfi

  3. Institute for Pathology, Johannes Gutenberg University Institute for Pathology, Mainz, Germany

    James Kirkpatrick

  4. LBI für experimentelle und klinisch , Wien, Austria

    Heinz Redl

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Haumer, A. et al. (2017). From Autologous Flaps to Engineered Vascularized Grafts for Bone Regeneration. In: Holnthoner, W., Banfi, A., Kirkpatrick, J., Redl, H. (eds) Vascularization for Tissue Engineering and Regenerative Medicine. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-21056-8_16-1

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