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Genetic Instability and Disease Prognostication

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Chromosomal Instability in Cancer Cells

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 200))

Abstract

Genetic instability is a striking feature of human cancers, with an impact on the genesis, progression and prognosis. The clinical importance of genomic instability and aneuploidy is underscored by its association with poor patient outcome in multiple cancer types, including breast and colon cancer. Interestingly, there is growing evidence that prognostic gene expression signatures simply reflect the degree of genomic instability. Additionally, also the proteome is affected by aneuploidy and has therefore become a powerful tool to screen for new targets for therapy, diagnosis and prognostication. In this context, the chapter presents the impact of genomic instability on disease prognostication occurring in human cancers.

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Authors and Affiliations

  1. Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University of Lübeck & University Medical Center Schleswig-Holstein, Lübeck, Germany

    Timo Gemoll & Jens K. Habermann

  2. Karolinska Biomic Center, Karolinska Institutet, Stockholm, Sweden

    Gert Auer

  3. Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA

    Thomas Ried

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  1. Timo Gemoll
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  2. Gert Auer
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  3. Thomas Ried
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  4. Jens K. Habermann
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Correspondence to Jens K. Habermann .

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Editors and Affiliations

  1. Visceral and Pediatric Surgery, Department of General, Göttingen, Germany

    B. Michael Ghadimi

  2. Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

    Thomas Ried

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Gemoll, T., Auer, G., Ried, T., Habermann, J.K. (2015). Genetic Instability and Disease Prognostication. In: Ghadimi, B., Ried, T. (eds) Chromosomal Instability in Cancer Cells. Recent Results in Cancer Research, vol 200. Springer, Cham. https://doi.org/10.1007/978-3-319-20291-4_4

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  • DOI: https://doi.org/10.1007/978-3-319-20291-4_4

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