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Chromosomal Instability in Cancer Cells

  • B. Michael Ghadimi
  • Thomas Ried

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 200)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Stefan K. Bohlander, Purvi M. Kakadia
    Pages 1-37
  3. Judith E. Simon, Bjorn Bakker, Floris Foijer
    Pages 39-60
  4. Jitendra Meena, K. Lenhard Rudolph, Cagatay Günes
    Pages 61-79
  5. Timo Gemoll, Gert Auer, Thomas Ried, Jens K. Habermann
    Pages 81-94
  6. Holger Bastians
    Pages 95-113
  7. Marian Grade, Michael J. Difilippantonio, Jordi Camps
    Pages 115-142
  8. Eduardo Torres
    Pages 143-164
  9. Milena Dürrbaum, Zuzana Storchová
    Pages 195-224

About this book

Introduction

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Keywords

Aneuploidy Cancer DNA Repair Disease Outcome Genomic Instability

Editors and affiliations

  • B. Michael Ghadimi
    • 1
  • Thomas Ried
    • 2
  1. 1.Visceral and Pediatric SurgeryDepartment of GeneralGöttingenGermany
  2. 2.Center for Cancer ResearchNational Cancer InstituteBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-20291-4
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-20290-7
  • Online ISBN 978-3-319-20291-4
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • Buy this book on publisher's site