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A study on the expression of interleukin(IL)-10 and IL-12 P35, P40 mRNA in the psoriatic lesions

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Summary

To investigate the possible role of interleukin (IL)-10 and IL-12 in the pathogenesis of psoriatic lesions and to supply theoretical basis for the gene therapy for psoriasis, the expression of IL-10 and IL-12 P35, P40 mRNA in 12 cases of psoriatic lesions and 6 normal skin tissues was detected by using RT-PCR technique. The results showed that the expression of IL-10 mRNA in the psoriatic lesions was significantly lower than that in the normal skin tissues (P<0. 001). The expression of IL-12 P35 was positive both in the psoriatic lesions and in the normal skin tissues. IL-12 P40 mRNA was expressed positively only in the psoriatic lesions but negatively in the normal skin tissues. It was suggested that IL-12 might take an important role in the occurrence and progression of psoriasis, but IL-10 might have certain role in the regression of psoriasis.

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Authors and Affiliations

  1. Department of Dermatology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan

    Cheng Jiqun (Master), Tu Yating, Li Jiawen, Huang Changzheng, Liu Zhixiang & Liu Daofan

  2. Wujing General Hospital, 100039, Beijing

    Cheng Jiqun (Master)

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  1. Cheng Jiqun
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  2. Tu Yating
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  3. Li Jiawen
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  4. Huang Changzheng
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  5. Liu Zhixiang
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  6. Liu Daofan
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Jiqun, C., Yating, T., Jiawen, L. et al. A study on the expression of interleukin(IL)-10 and IL-12 P35, P40 mRNA in the psoriatic lesions. Current Medical Science 21, 86–88 (2001). https://doi.org/10.1007/BF02888047

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  • DOI: https://doi.org/10.1007/BF02888047

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