Abstract
Lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have relevant biological and pharmacological properties, such as cytotoxicity, immunomodulation, and anti-inflammation. Some of them also have interesting effects on metabolism and anti-infectious properties. This review will compile chemical data, biological effects, and mechanisms on the most relevant lanostanoids isolated from fungi, such as those from Ganoderma lucidum, Poria cocos, Laetiporus sulphureus, Inonotus obliquus, Antrodia camphorata, Daedalea dickinsii, and other.
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Abbreviations
- ABCB:
-
ATP-binding cassette
- AIF:
-
Apoptosis-inducing factor
- AKT:
-
Protein kinase B
- AMPK:
-
AMP-activated kinase
- C/EBPα:
-
CCAAT-enhancer-binding protein-α
- CCAAT:
- cdk4:
-
Cyclin D kinase 4
- COX:
-
Cyclooxygenase
- CYP3A4:
-
Cytochrome P450 3A4
- DBD:
-
DNA-binding domain
- DMBA:
-
7,12-Dimethylbenz[a]anthracene
- EBV-EA:
-
Epstein-Barr virus early antigen
- ERK Erk:
-
Extracellular-regulated kinase
- FXR:
-
Farnesoid X receptor
- GLUT4:
-
Glucose transporter type 4
- GPDH:
-
Glycerol-3-phosphate dehydrogenase
- HIV:
-
Human immunodeficiency virus
- HO-1:
-
Heme-oxygenase-1
- hPXR:
-
Human pregnane X receptor
- IC50 :
-
Inhibitory concentration 50
- IFN-γ:
-
Interferon-γ
- IL:
-
Interleukin
- iNOS:
-
Inducible nitric oxide synthase
- IRS-1:
-
Insulin receptor substrate-1
- IκBα:
-
Inhibitor of κBα
- JAK:
-
Janus kinase
- JNK:
-
c-Jun N-terminal kinase
- LBD:
-
Ligand-binding domain
- LPS:
-
Lipopolysaccharide
- MDD:
-
Mean day of death
- MIC:
-
Minimum inhibitory concentration
- MMP-9:
-
Matrix metalloproteinase-9
- NF-κB:
-
Nuclear factor-κB
- NK:
-
Natural killer
- NO:
-
Nitric oxide
- Nrf2:
-
Nuclear factor (erythroid-derived 2)-like 2
- PI3K:
-
Phosphatidylinositol-4,5-bisphosphate 3-kinase
- PLA2 :
-
Phospholipase A2
- PARP:
-
Poly(ADP-ribose)-polymerase
- PPAR-γ:
-
Peroxisome proliferator-activated receptor-γ
- RXR:
-
Retinoid X receptor
- SREBP-1c:
-
Sterol regulatory element-binding protein-1c
- STAT3:
-
Signal transducer and activator of transcription 3
- T2DM:
-
Type 2 diabetes mellitus
- TNFα:
-
Tumor necrosis factor-α
- TPA:
-
12-O-Tetradecanoylphorbol-13-acetate
- uPA:
-
Urokinase-type plasminogen activator
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Ríos, JL., Andújar, I. (2015). Lanostanoids from Fungi as Potential Medicinal Agents. In: Mérillon, JM., Ramawat, K. (eds) Fungal Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-19456-1_19-1
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