Abstract
Bone morphogenetic proteins (BMPs) are a group of growth factors that induce the differentiation of osteoprogenitor cells into osteoblasts and stimulate the formation of new bone in areas requiring repair. This is critical in spinal fusion surgery and in the treatment of nonunion in long bone fractures where the formation of new bone is desired.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
Suggested Reading
Agarwal R, Williams K, Umscheid CA, Welch WC. Osteoinductive bone graft substitutes for lumbar fusion: a systematic review. J Neurosurg Spine. 2009;11(6):729–40.
Carragee EJ, Hurwitz EL, Weiner BK. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J. 2011;11(6):471–91.
Dimar 2nd JR, Glassman SD, Burkus JK, Pryor PW, Hardacker JW, Carreon LY. Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis. J Bone Joint Surg Am. 2009;91(6):1377–86.
Joseph V, Rampersaud YR. Heterotopic bone formation with the use of rhBMP2 in posterior minimal access interbody fusion: a CT analysis. Spine (Phila Pa 1976). 2007;32(25):2885–90.
Katayama Y, Matsuyama Y, Yoshihara H, Sakai Y, Nakamura H, Imagama S, Ito Z, Wakao N, Kamiya M, Yukawa Y, Kanemura T, Sato K, Iwata H, Ishiguro N. Clinical and radiographic outcomes of posterolateral lumbar spine fusion in humans using recombinant human bone morphogenetic protein-2: an average five-year follow-up study. Int Orthop. 2009;33(4):1061–7.
Mroz TE, Wang JC, Hashimoto R, Norvell DC. Complications related to osteobiologics use in spine surgery: a systematic review. Spine (Phila Pa 1976). 2010;35(9 Suppl):S86–104.
Murtagh RD, Quencer RM, Castellvi AE, Yue JJ. New techniques in lumbar spinal instrumentation: what the radiologist needs to know. Radiology. 2011;260(2):317–30.
Saigal G, Quencer R, Guest JD, Cristescu MM, Lebwohl N. Vertebral body osteolysis following the use of bone morphogenetic protein in spinal surgery: a mimicker of infection. J Neuroradiol. 2012;39(5):354–9.
Sethi A, Craig J, Bartol S, Chen W, Jacobson M, Coe C, Vaidya R. Radiographic and CT evaluation of recombinant human bone morphogenetic protein-2-assisted spinal interbody fusion. AJR Am J Roentgenol. 2011;197(1):W128–33.
Valdes MA, Thakur NA, Namdari S, Ciombor DM, Palumbo M. Recombinant bone morphogenic protein-2 in orthopaedic surgery: a review. Arch Orthop Trauma Surg. 2009;129(12):1651–7.
Valentin-Opran A, Wozney J, Csimma C, Lilly L, Riedel GE. Clinical evaluation of recombinant human bone morphogenetic protein-2. Clin Orthop Relat Res 2002;(395):110–120.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Reed, M.S., Johnson, J.M., Ginat, D.T. (2015). Recombinant Human Bone Morphogenetic Protein. In: Ginat, D., Small, J., Schaefer, P. (eds) Neuroimaging Pharmacopoeia. Springer, Cham. https://doi.org/10.1007/978-3-319-12715-6_52
Download citation
DOI: https://doi.org/10.1007/978-3-319-12715-6_52
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12714-9
Online ISBN: 978-3-319-12715-6
eBook Packages: MedicineMedicine (R0)