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Recombinant bone morphogenic protein-2 in orthopaedic surgery: a review

  • Orthopaedic Surgery
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Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Bone morphogenic proteins (BMPs) are pleiotropic regulators of bone volume, skeletal organogenesis and bone regeneration after a fracture. They function as signaling agents to affect cellular events like proliferation, differentiation and extracellular matrix synthesis. Clinically utilized rhBMP-2 combines rhBMP-2 with an osteoconductive carrier to induce bone growth and acts as a bone graft substitute. rhBMP-2, initially released in 2002, has been used primarily in spinal fusions in the lumbar and cervical regions. Recently, the application of rhBMP-2 has extended into the orthopedic trauma setting with increased application in open tibia fractures. This review outlines the history of development, molecular characteristics, toxicity and clinical applications.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Department of Orthopaedics, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA

    Mauricio A. Valdes, Nikhil A. Thakur, Deborah M. Ciombor & Mark Palumbo

  2. Department of Orthopaedics, University of Pennsylvania, Philadelphia, PA, USA

    Surena Namdari

  3. University Orthopedics, 2 Dudley St, Providence, RI, 02905, USA

    Mark Palumbo

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  1. Mauricio A. Valdes
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  2. Nikhil A. Thakur
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  3. Surena Namdari
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  4. Deborah M. Ciombor
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  5. Mark Palumbo
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Correspondence to Mark Palumbo.

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Valdes, M.A., Thakur, N.A., Namdari, S. et al. Recombinant bone morphogenic protein-2 in orthopaedic surgery: a review. Arch Orthop Trauma Surg 129, 1651–1657 (2009). https://doi.org/10.1007/s00402-009-0850-8

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  • DOI: https://doi.org/10.1007/s00402-009-0850-8

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