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Therapeutic and Prophylactic Tools for Sporotrichosis: Current Strategies and Future Tendencies

  • Chapter
Sporotrichosis

Abstract

Over the past 3 decades, important progress in the therapy of fungal infections has been made. Although several chemotherapeutic agents are relatively effective against the different species of the Sporothrix schenckii complex, even the primary drugs used to treat sporotrichosis are the ergosterol inhibitors: triazole compounds, terbinafine, and amphotericin B. Despite the general effectiveness of these drugs, diverse problems remain, including chronic therapy, toxicity manifestations, and fungal resistance, which limit their use. These problems have stimulated a search for new agents that might be active against a wide range of clinical isolates, that are well absorbed after oral administration, that are widely distributed throughout body tissues, including the central nervous system, and that are relatively nontoxic. This chapter reviews the current therapy strategies for human and animal sporotrichosis and updates the more relevant strategies in study for prophylaxis and treatment.

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Authors and Affiliations

  1. Laboratorio de Inmunotoxicología, Centro de Toxicología y Biomedicina (TOXIMED), Universidad de Ciencias Médicas, Autopista Nacional Km. 1 1/2, CP 90400, Santiago de Cuba, Cuba

    Alexander Batista-Duharte

  2. Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista Júlio Mesquita Filho (UNESP), Rod. Araraquara-Jaú km 1, 14801-902, Araraquara, SP, Brazil

    Alexander Batista-Duharte, Deivys Portuondo Fuentes & Iracilda Zeppone Carlos

  3. Instituto Nacional de Infectologia Evandro Chagas (INI), Fiocruz, Rio de Janeiro, Brazil

    Sandro Antonio Pereira

  4. Serviço de Infectologia, Instituto de Pesquisa Clinica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

    Dayvison Francis Saraiva Freitas & Maria Clara Gutierrez-Galhardo

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  1. Alexander Batista-Duharte
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  2. Sandro Antonio Pereira
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  3. Dayvison Francis Saraiva Freitas
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  4. Deivys Portuondo Fuentes
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  5. Maria Clara Gutierrez-Galhardo
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  6. Iracilda Zeppone Carlos
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Correspondence to Alexander Batista-Duharte .

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    Iracilda Zeppone Carlos

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Batista-Duharte, A., Pereira, S.A., Freitas, D.F.S., Fuentes, D.P., Gutierrez-Galhardo, M.C., Carlos, I.Z. (2015). Therapeutic and Prophylactic Tools for Sporotrichosis: Current Strategies and Future Tendencies. In: Zeppone Carlos, I. (eds) Sporotrichosis. Springer, Cham. https://doi.org/10.1007/978-3-319-11912-0_9

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