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PTSD and Fibromyalgia Syndrome: Focus on Prevalence, Mechanisms, and Impact

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Comprehensive Guide to Post-Traumatic Stress Disorder

Abstract

The association between fibromyalgia syndrome (FMS) and posttraumatic stress disorder (PTSD) is of growing interest in psychosocial research. The mechanisms by which both disorders are interconnected are not well understood. The article presents an overview of the study results available on the prevalence of PTSD in FMS patients, the known and proposed mechanisms of their association, and the impact of PTSD on FMS outcomes. In addition, practical issues related to PTSD and FMS in clinical practice are outlined.

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Abbreviations

FMS:

Fibromyalgia syndrome

PTSD:

Posttraumatic stress disorder

References

  • Amir M, Kaplan Z, Neumann L, et al. Posttraumatic stress disorder, tenderness and fibromyalgia. J Psychosom Res. 1997;42:607–13.

    Article  PubMed  Google Scholar 

  • Arnold LM, Fan J, Russell IJ, et al. The fibromyalgia family study: a genome-wide linkage scan study. Arthritis Rheum. 2013;65:1122–8.

    Article  PubMed Central  PubMed  Google Scholar 

  • Arnson Y, Amital D, Fostick L, et al. Physical activity protects male patients with post-traumatic stress disorder from developing severe fibromyalgia. Clin Exp Rheumatol. 2007;25(4):529–33.

    PubMed  Google Scholar 

  • Asmundson GJ, Katz J. Understanding pain and posttraumatic stress disorder comorbidity: do pathological responses to trauma alter the perception of pain? Pain. 2008;138(2):247–9.

    Article  PubMed  Google Scholar 

  • Bosco MA, Gallinati JL, Clark ME. Conceptualizing and treating comorbid chronic pain and PTSD. Pain Res Treat. 2013;2013:1–10.

    Article  Google Scholar 

  • Bradley LA. Pathophysiology of fibromyalgia. Am J Med. 2009;122(12 Suppl):S22–30.

    Article  PubMed Central  PubMed  Google Scholar 

  • Branco JC, Bannwarth B, Failde I, et al. Prevalence of fibromyalgia: a survey in five European countries. Semin Arthritis Rheum. 2010;39(6):448–53.

    Article  PubMed  Google Scholar 

  • Cagnie B, Coppieters I, Denecker S, et al. Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI. Semin Arthritis Rheum. 2014;44(1):68–75.

    Article  PubMed  Google Scholar 

  • Chandran A, Schaefer C, Ryan K, et al. The comparative economic burden of mild, moderate, and severe fibromyalgia: results from a retrospective chart review and cross-sectional survey of working-age U.S. adults. J Manag Care Pharm. 2012;18(6):415–26.

    PubMed  Google Scholar 

  • Ciccone DS, Elliott DK, Chandler HK, et al. Sexual and physical abuse in women with fibromyalgia syndrome: a test of the trauma hypothesis. Clin J Pain. 2005;21(5):378–86.

    Article  PubMed  Google Scholar 

  • Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547–55.

    Article  PubMed  Google Scholar 

  • Cohen H, Neumann L, Haiman Y, et al. Prevalence of post-traumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome? Semin Arthritis Rheum. 2002;32(1):38–50.

    Article  PubMed  Google Scholar 

  • de Souza JB, Goffaux P, Julien N, et al. Fibromyalgia subgroups: profiling distinct subgroups using the Fibromyalgia Impact Questionnaire. A preliminary study. Rheumatol Int. 2009;29(5):509–15.

    Article  PubMed  Google Scholar 

  • Dell’Osso L, Carmassi C, Consoli G, et al. Lifetime post-traumatic stress symptoms are related to the health-related quality of life and severity of pain/fatigue in patients with fibromyalgia. Clin Exp Rheumatol. 2011;29(6 Suppl 69):S73–8.

    PubMed  Google Scholar 

  • Docampo E, Collado A, Escaramís G, et al. Cluster analysis of clinical data identifies fibromyalgia subgroups. PLoS One. 2013;8(9):e74873.

    Article  PubMed Central  PubMed  Google Scholar 

  • Edwards RR, Bingham 3rd CO, Bathon J, et al. Catastrophizing and pain in arthritis, fibromyalgia, and other rheumatic diseases. Arthritis Rheum. 2006;55(2):325–32.

    Article  PubMed  Google Scholar 

  • Fietta P, Fietta P, Manganelli P. Fibromyalgia and psychiatric disorders. Acta Biomed. 2007;78:88–95.

    PubMed  Google Scholar 

  • Häuser W, Henningsen P. Fibromyalgia syndrome: a somatoform disorder? Eur J Pain. 2014;18(8):1052–9.

    Google Scholar 

  • Häuser W, Zimmer C, Felde E, et al. What are the key symptoms of fibromyalgia? Results of a survey of the German Fibromyalgia Association. Schmerz. 2008;22(2):176–83, German.

    Article  PubMed  Google Scholar 

  • Häuser W, Kosseva M, Üceyler N, et al. Emotional, physical, and sexual abuse in fibromyalgia syndrome: a systematic review with meta-analysis. Arthritis Care Res (Hoboken). 2011;63(6):808–20.

    Article  Google Scholar 

  • Häuser W, Bohn D, Kühn-Becker H, et al. Is the association of self-reported childhood maltreatments and adult fibromyalgia syndrome attributable to depression? A case control study. Clin Exp Rheumatol. 2012a;30(6 Suppl 74):59–64.

    PubMed  Google Scholar 

  • Häuser W, Glaesmer H, Schmutzer G, et al. Widespread pain in older Germans is associated with posttraumatic stress disorder and lifetime employment status–results of a cross-sectional survey with a representative population sample. Pain. 2012b;153(12):2466–72.

    Article  PubMed  Google Scholar 

  • Häuser W, Galek A, Erbslöh-Möller B, et al. Posttraumatic stress disorder in fibromyalgia syndrome: prevalence, temporal relationship between posttraumatic stress and fibromyalgia symptoms, and impact on clinical outcome. Pain. 2013;154:1216–23.

    Article  PubMed  Google Scholar 

  • Häuser W, Brähler E, Wolfe F, et al. Patient health questionnaire 15 as a generic measure of severity in fibromyalgia syndrome: surveys with patients of three different settings. J Psychosom Res. 2014;76(4):307–11.

    Article  PubMed  Google Scholar 

  • Haviland MG, Morton KR, Oda K, Fraser GE. Traumatic experiences, major life stressors, and self-reporting a physician-given fibromyalgia diagnosis. Psychiatry Res 2010; 177(3):335–41.

    Google Scholar 

  • Kessler RC, McLaughlin KA, Green JG, et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2010;197(5):378–85.

    Article  PubMed Central  PubMed  Google Scholar 

  • Knight T, Schaefer C, Chandran A, et al. Health-resource use and costs associated with fibromyalgia in France, Germany, and the United States. Clinicoecon Outcomes Res. 2013;5:171–80.

    Article  PubMed Central  PubMed  Google Scholar 

  • Köllner V, Häuser W, Klimczyk K, et al. Psychotherapy for patients with fibromyalgia syndrome. Systematic review, meta-analysis and guideline. Schmerz. 2012;26(3):291–6.

    Article  PubMed  Google Scholar 

  • Kosseva M, Schild S, Wilhelm-Schwenk R, et al. Comorbid depression mediates the association of childhood/adolescent maltreatment and fibromyalgia syndrome. A study with patients from different clinical settings. Schmerz. 2010;24(5):474–84.

    Article  PubMed  Google Scholar 

  • Kuiper NA, Derry PA. Depressed and nondepressed content self-reference in mild depressives. J Pers. 1982;50(1):67–80.

    Article  PubMed  Google Scholar 

  • Lange M, Petermann F. Influence of depression on fibromyalgia: a systematic review. Schmerz. 2010;24:326–33.

    Article  PubMed  Google Scholar 

  • Lee YH, Choi SJ, Ji JD, et al. Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int. 2010;32:417–26.

    Article  PubMed  Google Scholar 

  • Loftus EF, Davis D. Recovered memories. Annu Rev Clin Psychol. 2006;2:469–98.

    Article  PubMed  Google Scholar 

  • Lumley MA. Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution. Arthritis Res Ther. 2011;13(6):136.

    Article  PubMed Central  PubMed  Google Scholar 

  • Marschall U, Arnold B, Häuser W. Treatment and healthcare costs of fibromyalgia syndrome in Germany: analysis of the data of the Barmer health insurance (BEK) from 2008–2009. Schmerz. 2011;25(4):402–4, 406–10.

    Article  PubMed  Google Scholar 

  • McBeth J, Harkness EF, Silman AJ, et al. The role of workplace low-level mechanical trauma, posture and environment in the onset of chronic widespread pain. Rheumatology (Oxford). 2003;42:1486–94.

    Article  Google Scholar 

  • McIntyre A, Paisley D, Kouassi E, et al. Quetiapine fumarate extended-release for the treatment of major depression with comorbid fibromyalgia syndrome: a double-blind, randomized, placebo-controlled study. Arthritis Rheumatol. 2014;66(2):451–61.

    Article  PubMed  Google Scholar 

  • Mork PJ, Nilsen T. Sleep problems and risk of fibromyalgia: longitudinal data on an adult female population in Norway. Arthritis Rheum. 2012;64:281–4.

    Article  PubMed  Google Scholar 

  • Mork PJ, Vasseljen O, Nilsen TI. Association between physical exercise, body mass index, and risk of fibromyalgia: longitudinal data from the Norwegian Nord-Trøndelag Health Study. Arthritis Care Res. 2010;62:611–7.

    Article  Google Scholar 

  • Nakamura I, Nishioka K, Usui C, et al. An epidemiological internet survey of fibromyalgia and chronic pain in Japan. Arthritis Care Res (Hoboken). 2014;66(7):1093–101.

    Article  Google Scholar 

  • Näring GW, van Lankveld W, Geenen R. Somatoform dissociation and traumatic experiences in patients with rheumatoid arthritis and fibromyalgia. Clin Exp Rheumatol. 2007;25(6):872–7.

    PubMed  Google Scholar 

  • Otis JD, Keane TM, Kerns RD, et al. The development of an integrated treatment for veterans with comorbid chronic pain and posttraumatic stress disorder. Pain Med. 2009;10:1300.

    Article  PubMed  Google Scholar 

  • Plagge JM, Lu MW, Lovejoy TI, et al. Treatment of comorbid pain and PTSD in returning veterans: a collaborative approach utilizing behavioral activation. Pain Med. 2013;14:1164–72.

    Article  PubMed  Google Scholar 

  • Quartana PJ, Campbell CM, Edwards RR. Pain catastrophizing: a critical review. Expert Rev Neurother. 2009;9(5):745–58.

    Article  PubMed Central  PubMed  Google Scholar 

  • Raphael KG, Janal MN, Nayak S. Comorbidity of fibromyalgia and posttraumatic stress disorder symptoms in a community sample of women. Pain Med. 2004;5(1):33–41.

    Article  PubMed  Google Scholar 

  • Raphael KG, Janal MN, Nayak S, et al. Psychiatric comorbidities in a community sample of women with fibromyalgia. Pain. 2006;124(1–2):117–25.

    Article  PubMed  Google Scholar 

  • Roy-Byrne P, Smith WR, Goldberg J, et al. Post-traumatic stress disorder among patients with chronic pain and chronic fatigue. Psychol Med. 2004;34(2):363–8.

    Article  PubMed  Google Scholar 

  • Scheidt CE, Waller E, Endorf K, et al. Is brief psychodynamic psychotherapy in primary fibromyalgia syndrome with concurrent depression an effective treatment? A randomized controlled trial. Gen Hosp Psychiatry. 2013;35(2):160–7.

    Article  PubMed  Google Scholar 

  • Sharp TJ, Harvey AG. Chronic pain and posttraumatic stress disorder: mutual maintenance? Clin Psychol Rev. 2001;21(6):857–77.

    Article  PubMed  Google Scholar 

  • Sherman JJ, Turk DC, Okifuji A. Prevalence and impact of posttraumatic stress disorder-like symptoms on patients with fibromyalgia syndrome. Clin J Pain. 2000;16(2):127–34.

    Article  PubMed  Google Scholar 

  • Sommer C, Häuser W, Burgmer M, et al. Etiology and pathophysiology of fibromyalgia syndrome. Schmerz. 2012;26:259–67.

    Article  PubMed  Google Scholar 

  • Thieme K, Turk DC, Flor H. Comorbid depression and anxiety in fibromyalgia syndrome: relationship to somatic and psychosocial variables. Psychosom Med. 2004;66(6):837–44.

    Article  PubMed  Google Scholar 

  • Üçeyler N, Zeller D, Kahn AK, et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain. 2013;136:1857–67.

    Article  PubMed  Google Scholar 

  • Usui C, Hatta K, Aratani S, et al. Vulnerability to traumatic stress in fibromyalgia patients: 19 month follow-up after the great East Japan disaster. Arthritis Res Ther. 2013;15(5):R130.

    Article  PubMed Central  PubMed  Google Scholar 

  • Van Houdenhove B, Egle U, Luyten P. The role of life stress in fibromyalgia. Curr Rheumatol Rep. 2005;7:365–70.

    Article  PubMed  Google Scholar 

  • Wolfe F. Fibromyalgia wars. J Rheumatol. 2009;36(4):671–8.

    Article  PubMed  Google Scholar 

  • Wolfe F. Fibromyalgia research criteria. J Rheumatol. 2014;41(1):187.

    Google Scholar 

  • Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria, for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 1990;33(12):1863–4.

    Article  Google Scholar 

  • Wolfe F, Ross K, Anderson J, et al. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995;38:19–25.

    Article  PubMed  Google Scholar 

  • Wolfe F, Clauw DJ, Fitzcharles MA, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Rheum. 2010;62(5):600–10.

    Article  Google Scholar 

  • Wolfe F, Clauw DJ, Fitzcharles MA, et al. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol. 2011a;38:1113–22.

    Article  PubMed  Google Scholar 

  • Wolfe F, Häuser W, Hassett AL, et al. The development of fibromyalgia–I: examination of rates and predictors in patients with rheumatoid arthritis (RA). Pain. 2011b;152:291–9.

    Article  PubMed  Google Scholar 

  • Wolfe F, Brähler E, Hinz A, et al. Fibromyalgia prevalence, somatic symptom reporting, and the dimensionality of polysymptomatic distress: results from a survey of the general population. Arthritis Care Res (Hoboken). 2013;65:777–85.

    Article  Google Scholar 

  • Wolfe F, Häuser W, Walitt BT, et al. Fibromyalgia and physical trauma: the concepts we invent. J Rheumatol. 2014;41(9):1737–45.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department Internal Medicine 1, Klinikum Saarbrücken gGmbH, Winterberg 1., D-66119, Saarbrücken, Germany

    Winfried Häuser

  2. Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Weizmann St. 6, Tel Aviv, Israel

    Jacob Ablin

  3. National Center for Complementary and Integrative Health and National Institute of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA

    Brian Walitt

Authors
  1. Winfried Häuser
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  2. Jacob Ablin
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  3. Brian Walitt
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Corresponding author

Correspondence to Winfried Häuser .

Editor information

Editors and Affiliations

  1. Buckinghamshire New University, Uxbridge, Middlesex, United Kingdom

    Colin R. Martin

  2. Kings College, London, United Kingdom

    Victor R. Preedy

  3. University of Westminster, London, United Kingdom

    Vinood B. Patel

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Häuser, W., Ablin, J., Walitt, B. (2015). PTSD and Fibromyalgia Syndrome: Focus on Prevalence, Mechanisms, and Impact. In: Martin, C., Preedy, V., Patel, V. (eds) Comprehensive Guide to Post-Traumatic Stress Disorder. Springer, Cham. https://doi.org/10.1007/978-3-319-08613-2_52-1

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  • DOI: https://doi.org/10.1007/978-3-319-08613-2_52-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-08613-2

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