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Microfluidic Sensor for Noncontact Detection of Cell Flow in a Microchannel

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Sensors and Microsystems

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 268))

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Abstract

A microfluidic sensor for detection of cells flowing in a microchannel is presented. The sensor consists of a PolyDiMethylSiloxane layer with two planar microreservoirs connected by a microchannel. The bottom sides of the microreservoirs are faced to two sensing electrodes formed on a printed circuit board. A noncontact measurement is ensured by an insulator layer between the electrodes and the fluid. Particles flowing in the microchannel cause changes in the conductivity of the narrow path formed by the fluid, producing variations in the impedance between the electrodes. A tailored electronic interface based on a direct digital synthesis device is proposed to measure the impedance variations. In the experimental tests, the cell flow is detected by changes in the effective capacitance and conductance between the electrodes. These preliminary results are promising for biological measurements such as counting and sizing of cells in different matrices.

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Author information

Authors and Affiliations

  1. Department of Information Engineering, University of Brescia, Via Branze 38, 25123, Brescia, Italy

    M. Demori & V. Ferrari

  2. Department of Mechanical and Industrial Engineering, University of Brescia, Via Branze 38, 25123, Brescia, Italy

    P. Poesio & R. Pedrazzani

  3. Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy

    N. Steimberg & G. Mazzoleni

Authors
  1. M. Demori
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  2. V. Ferrari
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  3. P. Poesio
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  4. R. Pedrazzani
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  5. N. Steimberg
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  6. G. Mazzoleni
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Corresponding author

Correspondence to M. Demori .

Editor information

Editors and Affiliations

  1. Dept. of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy

    Corrado Di Natale

  2. Department of Information Engineering, University of Brescia, Brescia, Italy

    Vittorio Ferrari

  3. SENSOR Laboratory, IDASC, National Research Council (CNR), Brescia, Italy

    Andrea Ponzoni

  4. Department of Information Engineering, University of Brescia, Brescia, Italy

    Giorgio Sberveglieri

  5. Department of Information Engineering, University of Brescia, Brescia, Italy

    Marco Ferrari

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© 2014 Springer International Publishing Switzerland

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Demori, M., Ferrari, V., Poesio, P., Pedrazzani, R., Steimberg, N., Mazzoleni, G. (2014). Microfluidic Sensor for Noncontact Detection of Cell Flow in a Microchannel. In: Di Natale, C., Ferrari, V., Ponzoni, A., Sberveglieri, G., Ferrari, M. (eds) Sensors and Microsystems. Lecture Notes in Electrical Engineering, vol 268. Springer, Cham. https://doi.org/10.1007/978-3-319-00684-0_6

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  • DOI: https://doi.org/10.1007/978-3-319-00684-0_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-00683-3

  • Online ISBN: 978-3-319-00684-0

  • eBook Packages: EngineeringEngineering (R0)

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