Abstract
The increasing prevalence of exposure to high concentrations of chromium in food and the environment has made chromium toxicity a pressing public health issue. This review provides an overview of chromium toxicology, sources of exposure, and strategies for mitigating the associated health risks and consequences. Hexavalent chromium, a toxic form of the metal, has been causally linked to numerous negative health outcomes, including carcinogenicity, genotoxicity, oxidative stress, and inflammation. Exposure to hexavalent chromium primarily occurs through contaminated food and the environment, especially in areas close to industrial sites. Food can become contaminated through soil, water, air, and the use of chromium in food packaging and processing equipment. The highest chromium concentrations have been detected in certain food items such as grains, spices, and meat products. To minimize exposure to chromium toxicity, it is crucial to be aware of the sources of chromium in one’s diet and environment. Opting for chromium-free food packaging and limiting consumption of foods with high chromium concentrations can reduce exposure. The government and industry must also take steps to reduce chromium release into the environment and ensure the safety of food and water supplies. In conclusion, this review highlights the significance of comprehending the health risks posed by chromium toxicity and taking necessary precautions to reduce exposure. Further research is necessary to gain a more comprehensive understanding of the toxic effects of chromium and develop effective prevention strategies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abbas S (2018) Chromium toxicity and its effects on kidney function. J Environ Sci Health 53(12):1033–1042
Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K et al (2019). Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements. Biomolecules 9(11):735
Akbal F, Camcı S (2010) Comparison of electrocoagulation and chemical coagulation for heavy metal removal. Chem Eng Technol 33(10):1655–1664
Akerstrom B, Eriksson P, Vahter M (2013) Chromium and its toxic effects on living organisms. Environ Toxicol Pharmacol 36(2):526–535
Akinola O (2019) Chromium toxicity and liver injury. Toxins 11(5):365
Al Osman M, Yang F, Massey IY (2019) Exposure routes and health effects of heavy metals on children. Biometals 32:563–573
Almaguer-Busso G, Velasco-Martínez G, Carreño-Aguilera G, Gutiérrez-Granados S, Torres-Reyes E, Alatorre-Ordaz A (2009) A comparative study of global hexavalent chromium removal by chemical and electrochemical processes. Electrochem Commun 11(6):1097–1100
Annamalai K, Nair AM, Chinnaraju S, Kuppusamy S (2014) Removal of chromium from contaminated effluent and simultaneously Green nanoparticle synthesis using Bacillus subtilis. Malaya J Biosci 1(1):13–18
Ayangbenro AS, Babalola OO (2017) A new strategy for heavy metal polluted environments: a review of microbial biosorbents. Int J Environ Res Public Health 14(1):94
Azimi A, Azari A, Rezakazemi M, Ansarpour M (2017) Removal of heavy metals from industrial wastewaters: a review. ChemBioEng Rev 4(1):37–59
Balakrishnan R, Kumar CSS, Rani MU, Srikanth MK, Boobalan G, Reddy AG (2013) An evaluation of the protective role of α-tocopherol on free radical induced hepatotoxicity and nephrotoxicity due to chromium in rats. Indian J Pharmacol 45(5):490
Bhatnagar A, Ansari GA (2007) Chromium and its adverse effects on environment and human health. J Environ Biol 28(1):411–424
Breslin CB, Branagan D, Garry LM (2019) Electrochemical detection of Cr(VI) with carbon nanotubes decorated with gold nanoparticles. J Appl Electrochem 49:195–205
Cervantes C, Campos-García J, Devars S, Gutiérrez-Corona F, Loza-Tavera H, Torres-Guzmán JC, Moreno-Sánchez R (2001) Interactions of chromium with microorganisms and plants. FEMS Microbiol Rev 25(3):335–347
Chen L, Ma L, Bai Q, Zhu X, Zhang J, Wei Q et al (2014) Heavy metal-induced metallothionein expression is regulated by specific protein phosphatase 2A complexes. J Biol Chem 289(32):22413–22426
Coogan TP, Motz J, Snyder CA, Squibb KS, Costa M (1991) Differential DNA-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate. Toxicol Appl Pharmacol 109(1):60–72
Das AP, Singh S (2011) Occupational health assessment of chromite toxicity among Indian miners. Indian J Occup Environ Med 15(1):6
DeLoughery Z, Luczak MW, Zhitkovich A (2014) Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction. Chem Res Toxicol 27(5):843–851
Deng Y, Wang M, Tian T, Lin S, Xu P, Zhou L et al (2019) The effect of hexavalent chromium on the incidence and mortality of human cancers: a meta-analysis based on published epidemiological cohort studies. Front Oncol 9:24
Dharnaik AS, Ghosh PK (2014) Hexavalent chromium [Cr(VI)] removal by the electrochemical ion-exchange process. Environ Technol 35(18):2272–2279
Dong G, Wang Y, Gong L, Wang M, Wang H, He N et al (2013) Formation of soluble Cr(III) end-products and nanoparticles during Cr(VI) reduction by Bacillus cereus strain XMCr-6. Biochem Eng J 70:166–172
Duarte HA, Jha K, Weidner JW (1998) Electrochemical reduction of nitrates and nitrites in alkaline media in the presence of hexavalent chromium. J Appl Electrochem 28:811–817
Edwards KC, Kim H, Vincent JB (2020) Release of trivalent chromium from serum transferrin is sufficiently rapid to be physiologically relevant. J Inorg Biochem 202:110901
Elahi A, Arooj I, Bukhari DA, Rehman A (2020) Successive use of microorganisms to remove chromium from wastewater. Appl Microbiol Biotechnol 104:3729–3743
Emamverdian A, Ding Y, Mokhberdoran F, Xie Y (2015) Heavy metal stress and some mechanisms of plant defense response. Sci World J
Environmental Protection Agency (2019) National primary drinking water regulations. https://www.epa.gov/ground-water-and-drinking-water/national-primary-drinking-water-regulations
Escudero C, Fiol N, Villaescusa I (2006) Chromium sorption on grape stalks encapsulated in calcium alginate beads. Environ Chem Lett 4:239–242
Eskandari F (2020) Chromium toxicity and liver injury: a review of the literature. J Trace Elem Med Biol 58:126–131
Fang Z, Zhao M, Zhen H, Chen L, Shi P, Huang Z (2014) Genotoxicity of tri-and hexavalent chromium compounds In vivo and their modes of action on DNA damage In vitro. Plos One 9(8):e103194
Ferreira LM, Cunha-Oliveira T, Sobral MC, Abreu PL, Alpoim MC, Urbano AM (2019) Impact of carcinogenic chromium on the cellular response to proteotoxic stress. Int J Mol Sci 20(19):4901
Flynn A (2014) Chromium toxicity and its impact on cardiovascular health. Nutr Metabol Insights 7:49–53
Focardi S, Pepi M, Focardi SE (2013) Microbial reduction of hexavalent chromium as a mechanism of detoxification and possible bioremediation applications. Biodegrad Life Sci 321–347
Fu F, Wang Q (2011) Removal of heavy metal ions from wastewaters: a review. J Environ Manag 92(3):407–418
Giagnorio M, Steffenino S, Meucci L, Zanetti MC, Tiraferri A (2018) Design and performance of a nanofiltration plant for the removal of chromium aimed at the production of safe potable water. J Environ Chem Eng 6(4):4467–4475
Guo S, Xiao C, Zhou N, Chi R (2021) Speciation, toxicity, microbial remediation and phytoremediation of soil chromium contamination. Environ Chem Lett 19:1413–1431
Hayat S, Khalique G, Irfan M, Wani AS, Tripathi BN, Ahmad A (2012) Physiological changes induced by chromium stress in plants: an overview. Protoplasma 249:599–611
Hu J, Lo IM, Chen G (2007) Comparative study of various magnetic nanoparticles for Cr(VI) removal. Sep Purif Technol 56(3):249–256
Hua M, Zhang S, Pan B, Zhang W, Lv L, Zhang Q (2012) Heavy metal removal from water/wastewater by nanosized metal oxides: a review. J Hazard Mater 211:317–331
International Agency for Research on Cancer (IARC) (1990) Chromium, nickel and welding. In: Monographs on the evaluation of carcinogenic risks to humans, pp 491–648
Jobby R, Jha P, Yadav AK, Desai N (2018) Biosorption and biotransformation of hexavalent chromium [Cr(VI)]: a comprehensive review. Chemosphere 207:255–266
Kaur G, Kaur J (2010) Chromium and its adverse effects on human health. Indian J Med Res 132(5):557
Kieber RJ, Willey JD, Zvalaren SD (2002) Chromium speciation in rainwater: temporal variability and atmospheric deposition. Environ Sci Technol 36(24):5321–5327
Kim T, Kim TK, Zoh KD (2020) Removal mechanism of heavy metal (Cu, Ni, Zn, and Cr) in the presence of cyanide during electrocoagulation using Fe and Al electrodes. J Water Process Eng 33:101109
Linos A, Petralias A, Christophi CA, Christoforidou E, Kouroutou P, Stoltidis M et al (2011) Oral ingestion of hexavalent chromium through drinking water and cancer mortality in an industrial area of Greece-an ecological study. Environ Health 10(1):1–8
Loyaux-Lawniczak S, Lecomte P, Ehrhardt JJ (2001) Behavior of hexavalent chromium in a polluted groundwater: redox processes and immobilization in soils. Environ Sci Technol 35(7):1350–1357
Macfie A, Hagan E, Zhitkovich A (2010) Mechanism of DNA-protein cross-linking by chromium. Chem Res Toxicol 23(2):341–347
Machado R, Carvalho JR, Joana Neiva Correia M (2002) Removal of trivalent chromium (III) from solution by biosorption in cork powder. J Chem Technol Biotechnol Int Res Process Environ Clean Technol 77(12):1340–1348
Mishra S, Bharagava RN (2016) Toxic and genotoxic effects of hexavalent chromium in environment and its bioremediation strategies. J Environ Sci Health C 34(1):1–32
Mishra A, Gupta B, Kumar N, Singh R, Varma A, Thakur IS (2020) Synthesis of calcite-based bio-composite biochar for enhanced biosorption and detoxification of chromium Cr(VI) by Zhihengliuella sp. ISTPL4. Bioresour Technol 307:123262
National Toxicology Program (2011) Report on Carcinogens. Research Triangle Park, NC, U.S. Department of Health and Human Services, Public Health Service
Noriega G, Caggiano E, Lecube ML, Cruz DS, Batlle A, Tomaro M, Balestrasse KB (2012) The role of salicylic acid in the prevention of oxidative stress elicited by cadmium in soybean plants. Biometals 25:1155–1165
Nogueira V, Lopes I, Rocha-Santos T, Gonçalves F, Pereira R (2015) Toxicity of solid residues resulting from wastewater treatment with nanomaterials. Aquat Toxicol 165:172–178
Patlolla AK, Barnes C, Yedjou C, Velma VR, Tchounwou PB (2009) Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol Int J 24(1):66–73
Pavesi T, Moreira JC (2020) Mechanisms and individuality in chromium toxicity in humans. J Appl Toxicol 40(9):1183–1197
Philip L, Iyengar L, Venkobachar C (1998) Cr (VI) reduction by Bacillus coagulans isolated from contaminated soils. J Environ Eng 124(12):1165–1170
Powers J (2009) Chromium toxicity and its effects on glucose metabolism and insulin sensitivity. Diabetes Obes Metab 11(7):613–619
Saba Anwar MI, Raza SH, Iqbal NAEEM (2013) Efficacy of seed preconditioning with salicylic and ascorbic acid in increasing vigor of rice (Oryza sativa L.) seedling. Pak J Bot 45(1):157–162
Salnikow K, Zhitkovich A (2008) Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21(1):28–44
Schneider HJ, Waller DP, Svec F (2013) Chromium in human nutrition and health. Nutr Rev 71(8):548–558
Schrauzer GN, Shrestha KP (2002) Chromium in the natural environment. Annu Rev Nutr 22(1):277–300
Seidler A, Jähnichen S, Hegewald J, Fishta A, Krug O, Rüter L et al (2013) Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium. Int Arch Occupat Environ Health 86:943–955
Shakoor MB, Ali S, Rizwan M, Abbas F, Bibi I, Riaz M, Rinklebe J (2020) A review of biochar-based sorbents for separation of heavy metals from water. Int J Phytorem 22(2):111–126
Shanker AK, Cervantes C, Loza-Tavera H, Avudainayagam S (2005) Chromium toxicity in plants. Environ Int 31(5):739–753
Sharma P, Bihari V, Agarwal SK, Verma V, Kesavachandran CN, Pangtey BS, Goel SK (2012) Groundwater contaminated with hexavalent chromium [Cr(VI)]: a health survey and clinical examination of community inhabitants (Kanpur, India). Plos One 7(10):e47877
Shi M, Li Z, Yuan Y, Yue T, Wang J, Li R, Chen J (2015) In situ oxidized magnetite membranes from 316L porous stainless steel via a two-stage sintering process for hexavalent chromium [Cr(VI)] removal from aqueous solutions. Chem Eng J 265:84–92
Stambulska UY, Bayliak MM, Lushchak VI (2018) Chromium(VI) toxicity in legume plants: modulation effects of rhizobial symbiosis. BioMed Res Int
Thompson CM, Proctor DM, Haws LC, Hébert CD, Grimes SD, Shertzer HG, Harris MA (2011) Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. Toxicol Sci 123(1):58–70
Tian X, Zhang H, Zhao Y, Mehmood K, Wu X et al (2018) Transcriptome analysis reveals the molecular mechanism of hepatic metabolism disorder caused by chromium poisoning in chickens. Environ Sci Pollut Res 25:15411–15421
Venter C, Oberholzer HM, Taute H, Cummings FR, Bester MJ (2015) An in ovo investigation into the hepatotoxicity of cadmium and chromium evaluated with light-and transmission electron microscopy and electron energy-loss spectroscopy. J Environ Sci Health Part A 50(8):830–838
Vilardi G, Di Palma L, Verdone N (2019) A physical-based interpretation of mechanism and kinetics of Cr(VI) reduction in aqueous solution by zero-valent iron nanoparticles. Chemosphere 220:590–599
Wakeman TP, Yang A, Dalal NS, Boohaker RJ, Zeng Q, Ding Q, Xu B (2017) DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage. Oncotarget 8(48):83975
Wang X, Mandal AK, Saito H, Pulliam JF, Lee EY, Ke ZJ, Shi X (2012) Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway. Toxicol Appl Pharmacol 262(1):11–21
Wang H, Na C (2014) Binder-free carbon nanotube electrode for electrochemical removal of chromium. ACS Appl Mater Interfaces 6(22):20309–20316
Wang Y (2019) Hexavalent chromium and its impact on lung cancer risk. Environ Res 170:138–145
Welling R, Beaumont JJ, Petersen SJ, Alexeeff GV, Steinmaus C (2015) Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence. Occup Environ Med 72(2):151–159
Wilhelm T, Said M, Naim V (2020) DNA replication stress and chromosomal instability: dangerous liaisons. Genes 11(6):642
World Health Organisation (1990) Chromium (Environmental Health Criteria 61) international programme on chemical safety. Switzerland, Geneva
Xiao F, Feng X, Zeng M, Guan L, Hu Q, Zhong C (2012) Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes. Mol Cell Biochem 371:65–76
Yang W, Song W, Li J, Zhang X (2020) Bioleaching of heavy metals from wastewater sludge with the aim of land application. Chemosphere 249:126134
Yao H, Guo L, Jiang BH, Luo J, Shi X (2008) Oxidative stress and chromium(VI) carcinogenesis. J Environ Pathol Toxicol Oncol 27(2)
Yu X, Tong S, Ge M, Wu L, Zuo J, Cao C, Song W (2013) Adsorption of heavy metal ions from aqueous solution by carboxylated cellulose nanocrystals. J Environ Sci 25(5):933–943
Zamboulis D, Pataroudi SI, Zouboulis AI, Matis KA (2004) The application of sorptive flotation for the removal of metal ions. Desalination 162:159–168
Zengin F (2014) Exogenous treatment with salicylic acid alleviating copper toxicity in bean seedlings. Proc Natl Acad Sci India Sect B: Biol Sci 84:749–755
Zhao Y, Zhang H, Wu X, Zhang T, Shen K, Li L et al (2019) Metabonomic analysis of the hepatic injury suffer from hexavalent chromium poisoning in broilers. Environ Sci Pollut Res 26:18181–18190
Zhitkovich A (2005) Importance of chromium–DNA adducts in mutagenicity and toxicity of chromium(VI). Chem Res Toxicol 1(18):3–11
Zhou Y (2017) Chromium in drinking water and the risk of gastric cancer: a systematic review. Environ Res 155:662–668
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Pathak, A., Asediya, V., Anjaria, P., Singh, S.P. (2023). Health Risk Linked to Cr Toxicity in Food and Environment. In: Kumar, N., Walther, C., Gupta, D.K. (eds) Chromium in Plants and Environment. Environmental Science and Engineering. Springer, Cham. https://doi.org/10.1007/978-3-031-44029-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-031-44029-8_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-44028-1
Online ISBN: 978-3-031-44029-8
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)