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Prophylactic Antibiotics

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Dental Science for the Medical Professional

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Abstract

Physicians are generally not well versed in the field of dentistry. Despite this, they are frequently consulted regarding prophylactic antibiotics or asked to evaluate patients for medical optimization prior to dental procedures with which they lack familiarity. When physicians are unknowledgeable of the procedure in question, antibiotics may be inappropriately prescribed. This chapter aims to update healthcare providers with evidence from the current literature on antibiotic indication and selection prior to dental procedures. In order to understand the appropriate spectrum of activity necessary for dental procedures, it is important to review the constituents of the oropharyngeal microbiome. The chapter will also familiarize medical practitioners on specific dental procedures to provide an understanding of what their patients will be undergoing and to better delineate which dental procedures are considered “invasive.”

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References

  1. Stein K, Farmer J, Singhal S, Marra F, Sutherland S, Quiñonez C. The use and misuse of antibiotics in dentistry: a scoping review. J Am Dent Assoc. 2018;149(10):869–84.e5.

    Article  PubMed  Google Scholar 

  2. Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol. 2006;33(6):401–7.

    Article  PubMed  Google Scholar 

  3. Schlein RA, Kudlick EM, Reindorf CA, Gregory J, Royal GC. Toothbrushing and transient bacteremia in patients undergoing orthodontic treatment. Am J Orthod Dentofac Orthop. 1991;99(5):466–72.

    Article  CAS  Google Scholar 

  4. Akbulut Y, Goymen M, Zer Y, Buyuktas MA. Investigation of bacteremia after debonding procedures. Acta Odontol Scand. 2018;76(5):314–9.

    Article  CAS  PubMed  Google Scholar 

  5. Martin M. Is there a link between tooth brushing and infective endocarditis? Int Dent J. 2003;53(Suppl 3):187–90.

    Article  PubMed  Google Scholar 

  6. Chung A, Kudlick EM, Gregory JE, Royal GC, Reindorf CA. Toothbrushing and transient bacteremia in patients undergoing orthodontic treatment. Am J Orthod Dentofac Orthop. 1986;90(3):181–6.

    Article  CAS  Google Scholar 

  7. Deo PN, Deshmukh R. Oral microbiome: unveiling the fundamentals. J Oral Maxillofac Pathol. 2019;23(1):122–8.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kilian M, Chapple IL, Hannig M, Marsh PD, Meuric V, Pedersen AM, et al. The oral microbiome - an update for oral healthcare professionals. Br Dent J. 2016;221(10):657–66.

    Article  CAS  PubMed  Google Scholar 

  9. Lockhart PB, Durack DT. Oral microflora as a cause of endocarditis and other distant site infections. Infect Dis Clin N Am. 1999;13(4):833–50, vi.

    Article  CAS  Google Scholar 

  10. Doern CD, Burnham CA. It’s not easy being green: the viridans group streptococci, with a focus on pediatric clinical manifestations. J Clin Microbiol. 2010;48(11):3829–35.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Sutter VL. Anaerobes as normal oral flora. Rev Infect Dis. 1984;6(Suppl 1):S62–6.

    Article  PubMed  Google Scholar 

  12. Baltch AL, Schaffer C, Hammer MC, Sutphen NT, Smith RP, Conroy J, et al. Bacteremia following dental cleaning in patients with and without penicillin prophylaxis. Am Heart J. 1982;104(6):1335–9.

    Article  CAS  PubMed  Google Scholar 

  13. Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with toothbrushing and dental extraction. Circulation. 2008;117(24):3118–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Marchionni S, Toti P, Barone A, Covani U, Esposito M. The effectiveness of systemic antibiotic prophylaxis in preventing local complications after tooth extraction. A systematic review. Eur J Oral Implantol. 2017;10(2):127–32.

    PubMed  Google Scholar 

  15. Yoshida K, Kodama Y, Nagai T, Estacio Salazar AR, Kaneko S, Saito C, et al. Clinico-statistical survey of oral antimicrobial prophylaxis and surgical site infection regarding ordinary tooth extraction and mandibular wisdom tooth extraction in the dental outpatient clinic. J Infect Chemother. 2021;27(2):192–7.

    Article  CAS  PubMed  Google Scholar 

  16. Menon RK, Kar Yan L, Gopinath D, Botelho MG. Is there a need for postoperative antibiotics after third molar surgery? A 5-year retrospective study. J Investig Clin Dent. 2019;10(4):e12460.

    Article  PubMed  Google Scholar 

  17. Ren YF, Malmstrom HS. Effectiveness of antibiotic prophylaxis in third molar surgery: a meta-analysis of randomized controlled clinical trials. J Oral Maxillofac Surg. 2007;65(10):1909–21.

    Article  PubMed  Google Scholar 

  18. Reiland MD, Ettinger KS, Lohse CM, Viozzi CF. Does administration of oral versus intravenous antibiotics for third molar removal have an effect on the incidence of alveolar osteitis or postoperative surgical site infections? J Oral Maxillofac Surg. 2017;75(9):1801–8.

    Article  PubMed  Google Scholar 

  19. Halpern LR, Dodson TB. Does prophylactic administration of systemic antibiotics prevent postoperative inflammatory complications after third molar surgery? J Oral Maxillofac Surg. 2007;65(2):177–85.

    Article  PubMed  Google Scholar 

  20. Poeschl PW, Eckel D, Poeschl E. Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity? J Oral Maxillofac Surg. 2004;62(1):3–8; discussion 9.

    Article  PubMed  Google Scholar 

  21. Marcussen KB, Laulund AS, Jørgensen HL, Pinholt EM. A systematic review on effect of single-dose preoperative antibiotics at surgical osteotomy extraction of lower third molars. J Oral Maxillofac Surg. 2016;74(4):693–703.

    Article  PubMed  Google Scholar 

  22. Moreno-Drada JA, García-Perdomo HA. Effectiveness of antimicrobial prophylaxis in preventing the spread of infection as a result of oral procedures: a systematic review and meta-analysis. J Oral Maxillofac Surg. 2016;74(7):1313–21.

    Article  PubMed  Google Scholar 

  23. Morrow AJ, Dodson TB, Gonzalez ML, Chuang SK, Lang MS. Do postoperative antibiotics decrease the frequency of inflammatory complications following third molar removal? J Oral Maxillofac Surg. 2018;76(4):700–8.

    Article  PubMed  Google Scholar 

  24. Menon RK, Gopinath D, Li KY, Leung YY, Botelho MG. Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. Int J Oral Maxillofac Surg. 2019;48(2):263–73.

    Article  CAS  PubMed  Google Scholar 

  25. Iguchi R, Moroi A, Saito Y, Takayama A, Hiraide R, Yoshizawa K, et al. Evaluation of intravenous prophylaxis antibiotics for third molar extraction under general anesthesia. Odontology. 2020;108(4):681–7.

    Article  CAS  PubMed  Google Scholar 

  26. Isiordia-Espinoza MA, Aragon-Martinez OH, Martínez-Morales JF, Zapata-Morales JR. Risk of wound infection and safety profile of amoxicillin in healthy patients which required third molar surgery: a systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2015;53(9):796–804.

    Article  CAS  PubMed  Google Scholar 

  27. Arteagoitia MI, Barbier L, Santamaría J, Santamaría G, Ramos E. Efficacy of amoxicillin and amoxicillin/clavulanic acid in the prevention of infection and dry socket after third molar extraction. A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2016;21(4):e494–504.

    PubMed  PubMed Central  Google Scholar 

  28. Dobson M, Pillon L, Kwon O, Innes N. Chlorhexidine gel to prevent alveolar osteitis following mandibular third molar extractions. Evid Based Dent. 2018;19(1):16–7.

    Article  PubMed  Google Scholar 

  29. Simonis P, Dufour T, Tenenbaum H. Long-term implant survival and success: a 10-16-year follow-up of non-submerged dental implants. Clin Oral Implants Res. 2010;21(7):772–7.

    Article  PubMed  Google Scholar 

  30. Singh Gill A, Morrissey H, Rahman A. A systematic review and meta-analysis evaluating antibiotic prophylaxis in dental implants and extraction procedures. Medicina (Kaunas). 2018;54(6):95.

    Article  PubMed  Google Scholar 

  31. Canullo L, Troiano G, Sbricoli L, Guazzo R, Laino L, Caiazzo A, et al. The use of antibiotics in implant therapy: a systematic review and meta-analysis with trial sequential analysis on early implant failure. Int J Oral Maxillofac Implants. 2020;35(3):485–94.

    Article  PubMed  Google Scholar 

  32. Chirilă L, Rotaru C, Filipov I, Săndulescu M. Management of acute maxillary sinusitis after sinus bone grafting procedures with simultaneous dental implants placement - a retrospective study. BMC Infect Dis. 2016;16(Suppl 1):94.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Hai JH, Lee C, Kapila YL, Chaffee BW, Armitage GC. Antibiotic prescribing practices in periodontal surgeries with and without bone grafting. J Periodontol. 2020;91(4):508–15.

    Article  PubMed  Google Scholar 

  34. Lewis T, Grant R. Observation relating to subascute infective endocarditis. Heart. 1923;10:21–9.

    Google Scholar 

  35. Lockhart PB, Hanson NB, Ristic H, Menezes AR, Baddour L. Acceptance among and impact on dental practitioners and patients of American Heart Association recommendations for antibiotic prophylaxis. J Am Dent Assoc. 2013;144(9):1030–5.

    Article  PubMed  Google Scholar 

  36. Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG Jr, Bayer AS, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the international collaboration on endocarditis-prospective cohort study. Arch Intern Med. 2009;169(5):463–73.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Lone AN, Khan M, Khan MU, Khan SU, Balla S. Abstract 28: health care cost burden of infective endocarditis in United States: a nationwide study. Circ Cardiovasc Qual Outcomes. 2020;13(Suppl_1):A28-A.

    Article  Google Scholar 

  38. Pant S, Patel NJ, Deshmukh A, Golwala H, Patel N, Badheka A, et al. Trends in infective endocarditis incidence, microbiology, and valve replacement in the United States from 2000 to 2011. J Am Coll Cardiol. 2015;65(19):2070–6.

    Article  PubMed  Google Scholar 

  39. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116(15):1736–54.

    Article  PubMed  Google Scholar 

  40. Sullam PM, Drake TA, Sande MA. Pathogenesis of endocarditis. Am J Med. 1985;78(6b):110–5.

    Article  CAS  PubMed  Google Scholar 

  41. Wilson WR, Gewitz M, Lockhart PB, Bolger AF, DeSimone DC, Kazi DS, et al. Prevention of Viridans group streptococcal infective endocarditis: a scientific statement from the American Heart Association. Circulation. 2021;143(20):e963–e78.

    Article  PubMed  Google Scholar 

  42. Hall G, Heimdahl A, Nord CE. Bacteremia after oral surgery and antibiotic prophylaxis for endocarditis. Clin Infect Dis. 1999;29(1):1–8; quiz 9–10.

    Article  CAS  PubMed  Google Scholar 

  43. Heimdahl A, Hall G, Hedberg M, Sandberg H, Söder PO, Tunér K, et al. Detection and quantitation by lysis-filtration of bacteremia after different oral surgical procedures. J Clin Microbiol. 1990;28(10):2205–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Hubers SA, DeSimone DC, Gersh BJ, Anavekar NS. Infective endocarditis: a contemporary review. Mayo Clin Proc. 2020;95(5):982–97.

    Article  PubMed  Google Scholar 

  45. Pallasch TJ, Wahl MJ. Focal infection: new age or ancient history? Endod Top. 2003;4(1):32–45.

    Article  Google Scholar 

  46. Garg P, Ko DT, Bray Jenkyn KM, Li L, Shariff SZ. Infective endocarditis hospitalizations and antibiotic prophylaxis rates before and after the 2007 American Heart Association guideline revision. Circulation. 2019;140(3):170–80.

    Article  PubMed  Google Scholar 

  47. Rogers AM, Schiller NB. Impact of the first nine months of revised infective endocarditis prophylaxis guidelines at a university hospital: so far so good. J Am Soc Echocardiogr. 2008;21(6):775.

    Article  PubMed  Google Scholar 

  48. Desimone DC, Tleyjeh IM, Correa de Sa DD, Anavekar NS, Lahr BD, Sohail MR, et al. Incidence of infective endocarditis caused by viridans group streptococci before and after publication of the 2007 American Heart Association’s endocarditis prevention guidelines. Circulation. 2012;126(1):60–4.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Pasquali SK, He X, Mohamad Z, McCrindle BW, Newburger JW, Li JS, et al. Trends in endocarditis hospitalizations at US children’s hospitals: impact of the 2007 American Heart Association antibiotic prophylaxis guidelines. Am Heart J. 2012;163(5):894–9.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Bikdeli B, Wang Y, Kim N, Desai MM, Quagliarello V, Krumholz HM. Trends in hospitalization rates and outcomes of endocarditis among Medicare beneficiaries. J Am Coll Cardiol. 2013;62(23):2217–26.

    Article  PubMed  PubMed Central  Google Scholar 

  51. DeSimone DC, Tleyjeh IM, Correa de Sa DD, Anavekar NS, Lahr BD, Sohail MR, et al. Incidence of infective endocarditis due to Viridans group streptococci before and after the 2007 American Heart Association’s prevention guidelines: an extended evaluation of the Olmsted County, Minnesota, population and nationwide inpatient sample. Mayo Clin Proc. 2015;90(7):874–81.

    Google Scholar 

  52. Toyoda N, Chikwe J, Itagaki S, Gelijns AC, Adams DH, Egorova NN. Trends in infective endocarditis in California and New York state, 1998-2013. JAMA. 2017;317(16):1652–60.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Bates KE, Hall M, Shah SS, Hill KD, Pasquali SK. Trends in infective endocarditis hospitalisations at United States children’s hospitals from 2003 to 2014: impact of the 2007 American Heart Association antibiotic prophylaxis guidelines. Cardiol Young. 2017;27(4):686–90.

    Article  PubMed  Google Scholar 

  54. Sakai Bizmark R, Chang RR, Tsugawa Y, Zangwill KM, Kawachi I. Impact of AHA’s 2007 guideline change on incidence of infective endocarditis in infants and children. Am Heart J. 2017;189:110–9.

    Article  PubMed  Google Scholar 

  55. van den Brink FS, Swaans MJ, Hoogendijk MG, Alipour A, Kelder JC, Jaarsma W, et al. Increased incidence of infective endocarditis after the 2009 European Society of Cardiology guideline update: a nationwide study in The Netherlands. Eur Heart J Qual Care Clin Outcomes. 2017;3(2):141–7.

    Article  PubMed  Google Scholar 

  56. Keller K, von Bardeleben RS, Ostad MA, Hobohm L, Munzel T, Konstantinides S, et al. Temporal trends in the prevalence of infective endocarditis in Germany between 2005 and 2014. Am J Cardiol. 2017;119(2):317–22.

    Article  PubMed  Google Scholar 

  57. Dayer MJ, Jones S, Prendergast B, Baddour LM, Lockhart PB, Thornhill MH. Incidence of infective endocarditis in England, 2000-13: a secular trend, interrupted time-series analysis. Lancet. 2015;385(9974):1219–28.

    Article  PubMed  Google Scholar 

  58. Suda KJ, Calip GS, Zhou J, Rowan S, Gross AE, Hershow RC, et al. Assessment of the appropriateness of antibiotic prescriptions for infection prophylaxis before dental procedures, 2011 to 2015. JAMA Netw Open. 2019;2(5):e193909.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Freed LA, Levy D, Levine RA, Larson MG, Evans JC, Fuller DL, et al. Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med. 1999;341(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  60. Delling FN, Vasan RS. Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation. 2014;129(21):2158–70.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Devereux RB, Jones EC, Roman MJ, Howard BV, Fabsitz RR, Liu JE, et al. Prevalence and correlates of mitral valve prolapse in a population-based sample of American Indians: the Strong Heart Study. Am J Med. 2001;111(9):679–85.

    Article  CAS  PubMed  Google Scholar 

  62. Katan O, Michelena HI, Avierinos JF, Mahoney DW, DeSimone DC, Baddour LM, et al. Incidence and predictors of infective endocarditis in mitral valve prolapse: a population-based study. Mayo Clin Proc. 2016;91(3):336–42.

    Article  PubMed  Google Scholar 

  63. Steckelberg JM, Wilson WR. Risk factors for infective endocarditis. Infect Dis Clin N Am. 1993;7(1):9–19.

    Article  CAS  Google Scholar 

  64. MacMahon SW, Hickey AJ, Wilcken DE, Wittes JT, Feneley MP, Hickie JB. Risk of infective endocarditis in mitral valve prolapse with and without precordial systolic murmurs. Am J Cardiol. 1987;59(1):105–8.

    Article  CAS  PubMed  Google Scholar 

  65. Zegri-Reiriz I, de Alarcón A, Muñoz P, Martínez Sellés M, González-Ramallo V, Miro JM, et al. Infective endocarditis in patients with bicuspid aortic valve or mitral valve prolapse. J Am Coll Cardiol. 2018;71(24):2731–40.

    Article  PubMed  Google Scholar 

  66. Glaser N, Jackson V, Holzmann MJ, Franco-Cereceda A, Sartipy U. Prosthetic valve endocarditis after surgical aortic valve replacement. Circulation. 2017;136(3):329–31.

    Article  PubMed  Google Scholar 

  67. Ferrieri P, Gewitz MH, Gerber MA, Newburger JW, Dajani AS, Shulman ST, et al. Unique features of infective endocarditis in childhood. Pediatrics. 2002;109(5):931–43.

    Article  PubMed  Google Scholar 

  68. Manne MB, Shrestha NK, Lytle BW, Nowicki ER, Blackstone E, Gordon SM, et al. Outcomes after surgical treatment of native and prosthetic valve infective endocarditis. Ann Thorac Surg. 2012;93(2):489–93.

    Article  PubMed  Google Scholar 

  69. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. 2015 ESC guidelines for the management of infective endocarditis: the Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075–128.

    Article  PubMed  Google Scholar 

  70. Dodo H, Child JS. Infective endocarditis in congenital heart disease. Cardiol Clin. 1996;14(3):383–92.

    Article  CAS  PubMed  Google Scholar 

  71. Martin JM, Neches WH, Wald ER. Infective endocarditis: 35 years of experience at a children’s hospital. Clin Infect Dis. 1997;24(4):669–75.

    Article  CAS  PubMed  Google Scholar 

  72. Coward K, Tucker N, Darville T. Infective endocarditis in Arkansan children from 1990 through 2002. Pediatr Infect Dis J. 2003;22(12):1048–52.

    Article  PubMed  Google Scholar 

  73. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Veen G, et al. Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population. Eur Heart J. 2011;32(15):1926–34.

    Article  PubMed  Google Scholar 

  74. Mylonakis E, Calderwood SB. Infective endocarditis in adults. N Engl J Med. 2001;345(18):1318–30.

    Article  CAS  PubMed  Google Scholar 

  75. Rushani D, Kaufman JS, Ionescu-Ittu R, Mackie AS, Pilote L, Therrien J, et al. Infective endocarditis in children with congenital heart disease: cumulative incidence and predictors. Circulation. 2013;128(13):1412–9.

    Article  PubMed  Google Scholar 

  76. Kuijpers JM, Koolbergen DR, Groenink M, Peels KCH, Reichert CLA, Post MC, et al. Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material. Eur Heart J. 2017;38(26):2048–56.

    PubMed  Google Scholar 

  77. Myles O, Thomas WJ, Daniels JT, Aronson N. Infected endovascular stents managed with medical therapy alone. Catheter Cardiovasc Interv. 2000;51(4):471–6.

    Article  CAS  PubMed  Google Scholar 

  78. Baddour LM, Bettmann MA, Bolger AF, Epstein AE, Ferrieri P, Gerber MA, et al. Nonvalvular cardiovascular device-related infections. Circulation. 2003;108(16):2015–31.

    Article  PubMed  Google Scholar 

  79. Que YA, François P, Haefliger JA, Entenza JM, Vaudaux P, Moreillon P. Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis. Infect Immun. 2001;69(10):6296–302.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Belle EV, Tio FO, Couffinhal T, Maillard L, Passeri J, Isner JM. Stent endothelialization. Circulation. 1997;95(2):438–48.

    Article  PubMed  Google Scholar 

  81. Gordon RJ, Quagliarello B, Lowy FD. Ventricular assist device-related infections. Lancet Infect Dis. 2006;6(7):426–37.

    Article  PubMed  Google Scholar 

  82. Gordon RJ, Weinberg AD, Pagani FD, Slaughter MS, Pappas PS, Naka Y, et al. Prospective, multicenter study of ventricular assist device infections. Circulation. 2013;127(6):691–702.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Trachtenberg BH, Cordero-Reyes A, Elias B, Loebe M. A review of infections in patients with left ventricular assist devices: prevention, diagnosis and management. Methodist Debakey Cardiovasc J. 2015;11(1):28–32.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Pereda D, Conte JV. Left ventricular assist device driveline infections. Cardiol Clin. 2011;29(4):515–27.

    Article  PubMed  Google Scholar 

  85. Leuck AM. Left ventricular assist device driveline infections: recent advances and future goals. J Thorac Dis. 2015;7(12):2151–7.

    PubMed  PubMed Central  Google Scholar 

  86. Söderlund C, Rådegran G. Immunosuppressive therapies after heart transplantation--the balance between under- and over-immunosuppression. Transplant Rev (Orlando). 2015;29(3):181–9.

    Article  PubMed  Google Scholar 

  87. Sherman-Weber S, Axelrod P, Suh B, Rubin S, Beltramo D, Manacchio J, et al. Infective endocarditis following orthotopic heart transplantation: 10 cases and a review of the literature. Transpl Infect Dis. 2004;6(4):165–70.

    Article  CAS  PubMed  Google Scholar 

  88. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87(3):978–82.

    Article  CAS  PubMed  Google Scholar 

  89. Kotagal M, Symons RG, Hirsch IB, Umpierrez GE, Dellinger EP, Farrokhi ET, et al. Perioperative hyperglycemia and risk of adverse events among patients with and without diabetes. Ann Surg. 2015;261(1):97–103.

    Article  PubMed  Google Scholar 

  90. Frisch A, Chandra P, Smiley D, Peng L, Rizzo M, Gatcliffe C, et al. Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery. Diabetes Care. 2010;33(8):1783–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Clement S, Braithwaite SS, Magee MF, Ahmann A, Smith EP, Schafer RG, et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care. 2004;27(2):553.

    Article  PubMed  Google Scholar 

  92. Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev. 2020;16(5):442–9.

    PubMed  PubMed Central  Google Scholar 

  93. Jafar N, Edriss H, Nugent K. The effect of short-term hyperglycemia on the innate immune system. Am J Med Sci. 2016;351(2):201–11.

    Article  PubMed  Google Scholar 

  94. Alexander RE. Routine prophylactic antibiotic use in diabetic dental patients. J Calif Dent Assoc. 1999;27(8):611–8.

    CAS  PubMed  Google Scholar 

  95. Lockhart PB, Loven B, Brennan MT, Fox PC. The evidence base for the efficacy of antibiotic prophylaxis in dental practice. J Am Dent Assoc. 2007;138(4):458–74; quiz 534–5, 437.

    Article  PubMed  Google Scholar 

  96. Wukich DK. Diabetes and its negative impact on outcomes in orthopaedic surgery. World J Orthop. 2015;6(3):331–9.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Navaratnarajah M, Rea R, Evans R, Gibson F, Antoniades C, Keiralla A, et al. Effect of glycaemic control on complications following cardiac surgery: literature review. J Cardiothorac Surg. 2018;13(1):10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Moghissi ES, Korytkowski MT, DiNardo M, Einhorn D, Hellman R, Hirsch IB, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32(6):1119–31.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Umpierrez GE, Hellman R, Korytkowski MT, Kosiborod M, Maynard GA, Montori VM, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(1):16–38.

    Article  CAS  PubMed  Google Scholar 

  100. Dhatariya K, Levy N, Kilvert A, Watson B, Cousins D, Flanagan D, et al. NHS diabetes guideline for the perioperative management of the adult patient with diabetes. Diabet Med. 2012;29(4):420–33.

    Article  CAS  PubMed  Google Scholar 

  101. Duncan AE. Hyperglycemia and perioperative glucose management. Curr Pharm Des. 2012;18(38):6195–203.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Duggan EW, Carlson K, Umpierrez GE. Perioperative hyperglycemia management: an update. Anesthesiology. 2017;126(3):547–60.

    Article  PubMed  Google Scholar 

  103. Seymour RA, Whitworth JM. Antibiotic prophylaxis for endocarditis, prosthetic joints, and surgery. Dent Clin N Am. 2002;46(4):635–51.

    Article  PubMed  Google Scholar 

  104. Perfetti DC, Boylan MR, Naziri Q, Paulino CB, Kurtz SM, Mont MA. Have periprosthetic hip infection rates plateaued? J Arthroplast. 2017;32(7):2244–7.

    Article  Google Scholar 

  105. Berbari EF, Osmon DR, Carr A, Hanssen AD, Baddour LM, Greene D, et al. Dental procedures as risk factors for prosthetic hip or knee infection: a hospital-based prospective case-control study. Clin Infect Dis. 2010;50(1):8–16.

    Article  PubMed  Google Scholar 

  106. Premkumar A, Kolin DA, Farley KX, Wilson JM, McLawhorn AS, Cross MB, et al. Projected economic burden of periprosthetic joint infection of the hip and knee in the United States. J Arthroplast. 2021;36(5):1484–9.e3.

    Article  Google Scholar 

  107. Lum ZC, Natsuhara KM, Shelton TJ, Giordani M, Pereira GC, Meehan JP. Mortality during total knee periprosthetic joint infection. J Arthroplast. 2018;33(12):3783–8.

    Article  Google Scholar 

  108. Watters W III, Rethman MP, Hanson NB, Abt E, Anderson PA, Carroll KC, et al. Prevention of orthopaedic implant infection in patients undergoing dental procedures. J Am Acad Orthop Surg. 2013;21(3):180–9.

    Article  PubMed  Google Scholar 

  109. Rosteius T, Jansen O, Fehmer T, Baecker H, Citak M, Schildhauer TA, et al. Evaluating the microbial pattern of periprosthetic joint infections of the hip and knee. J Med Microbiol. 2018;67(11):1608–13.

    Article  CAS  PubMed  Google Scholar 

  110. Kotzé MJ. Prosthetic joint infection, dental treatment and antibiotic prophylaxis. Orthop Rev (Pavia). 2009;1(1):e7.

    PubMed  Google Scholar 

  111. McNally CM, Visvanathan R, Liberali S, Adams RJ. Antibiotic prophylaxis for dental treatment after prosthetic joint replacement: exploring the orthopaedic surgeon’s opinion. Arthroplast Today. 2016;2(3):123–6.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Ward KA, Brundo GC, Nunn M, Wee AG. Current practices of the 2012 antibiotic prophylaxis recommendations for orthopaedic implants in a mid-West City. Int J Health Sci. 2015;3.

    Google Scholar 

  113. Colterjohn T, de Beer J, Petruccelli D, Zabtia N, Winemaker M. Antibiotic prophylaxis for dental procedures at risk of causing bacteremia among post-total joint arthroplasty patients: a survey of Canadian orthopaedic surgeons and dental surgeons. J Arthroplast. 2014;29(6):1091–7.

    Article  Google Scholar 

  114. Cummings SR, Lui LY, Eastell R, Allen IE. Association between drug treatments for patients with osteoporosis and overall mortality rates: a meta-analysis. JAMA Intern Med. 2019;179(11):1491–500.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61(9):1115–7.

    Article  PubMed  Google Scholar 

  116. Hellstein JW, Adler RA, Edwards B, Jacobsen PL, Kalmar JR, Koka S, et al. Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: executive summary of recommendations from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2011;142(11):1243–51.

    Article  CAS  PubMed  Google Scholar 

  117. Lo JC, O’Ryan FS, Gordon NP, Yang J, Hui RL, Martin D, et al. Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure. J Oral Maxillofac Surg. 2010;68(2):243–53.

    Article  PubMed  Google Scholar 

  118. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg. 2014;72(10):1938–56.

    Article  PubMed  Google Scholar 

  119. Tsao C, Darby I, Ebeling PR, Walsh K, O’Brien-Simpson N, Reynolds E, et al. Oral health risk factors for bisphosphonate-associated jaw osteonecrosis. J Oral Maxillofac Surg. 2013;71(8):1360–6.

    Article  PubMed  Google Scholar 

  120. Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, et al. Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127(2):117–35.

    Article  PubMed  Google Scholar 

  121. Jeong HG, Hwang JJ, Lee JH, Kim YH, Na JY, Han SS. Risk factors of osteonecrosis of the jaw after tooth extraction in osteoporotic patients on oral bisphosphonates. Imaging Sci Dent. 2017;47(1):45–50.

    Article  PubMed  PubMed Central  Google Scholar 

  122. Montefusco V, Gay F, Spina F, Miceli R, Maniezzo M, Teresa Ambrosini M, et al. Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates. Leuk Lymphoma. 2008;49(11):2156–62.

    Article  CAS  PubMed  Google Scholar 

  123. Bermúdez-Bejarano EB, Serrera-Figallo M, Gutiérrez-Corrales A, Romero-Ruiz MM, Castillo-de-Oyagüe R, Gutiérrez-Pérez JL, et al. Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates. J Clin Exp Dent. 2017;9(1):e141–e9.

    PubMed  PubMed Central  Google Scholar 

  124. Poxleitner P, Engelhardt M, Schmelzeisen R, Voss P. The prevention of medication-related osteonecrosis of the jaw. Dtsch Arztebl Int. 2017;114(5):63–9.

    PubMed  PubMed Central  Google Scholar 

  125. Dental management of patients receiving oral bisphosphonate therapy: expert panel recommendations. J Am Dent Assoc 2006;137(8):1144–50.

    Google Scholar 

  126. Nahass RG, Weinstein MP, Bartels J, Gocke DJ. Infective endocarditis in intravenous drug users: a comparison of human immunodeficiency virus type 1-negative and -positive patients. J Infect Dis. 1990;162(4):967–70.

    Article  CAS  PubMed  Google Scholar 

  127. Bestetti RB, Figueiredo JF, Da Costa JC. Salmonella tricuspid endocarditis in an intravenous drug abuser with human immunodeficiency virus infection. Int J Cardiol. 1991;30(3):361–2.

    Article  CAS  PubMed  Google Scholar 

  128. Riancho JA, Echevarría S, Napal J, Martin Duran R, Gonzalez MJ. Endocarditis due to Listeria monocytogenes and human immunodeficiency virus infection. Am J Med. 1988;85(5):737.

    Article  CAS  PubMed  Google Scholar 

  129. American Academy of Pediatric Dentistry. Antibiotic prophylaxis for dental patients at risk for infection. The reference manual of pediatric dentistry. Chicago, III: American academy of pediatric dentistry; 2022:500–6.

    Google Scholar 

  130. Zhang M, Differding MK, Benjamin-Neelon SE, Østbye T, Hoyo C, Mueller NT. Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome. Ann Clin Microbiol Antimicrob. 2019;18(1):18.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Kuperman AA, Koren O. Antibiotic use during pregnancy: how bad is it? BMC Med. 2016;14(1):91.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Stokholm J, Schjørring S, Eskildsen CE, Pedersen L, Bischoff AL, Følsgaard N, et al. Antibiotic use during pregnancy alters the commensal vaginal microbiota. Clin Microbiol Infect. 2014;20(7):629–35.

    Article  CAS  PubMed  Google Scholar 

  133. Mueller NT, Whyatt R, Hoepner L, Oberfield S, Dominguez-Bello MG, Widen EM, et al. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. Int J Obes. 2015;39(4):665–70.

    Article  CAS  Google Scholar 

  134. Bombassaro AM, Wetmore SJ, John MA. Clostridium difficile colitis following antibiotic prophylaxis for dental procedures. J Can Dent Assoc. 2001;67(1):20–2.

    CAS  PubMed  Google Scholar 

  135. Thornhill MH, Dayer M, Lockhart PB, Prendergast B. Antibiotic prophylaxis of infective endocarditis. Curr Infect Dis Rep. 2017;19(2):9.

    Article  PubMed  PubMed Central  Google Scholar 

  136. Hancox JC, Hasnain M, Vieweg WV, Crouse EL, Baranchuk A. Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: a narrative review based on the study of case reports. Ther Adv Infect Dis. 2013;1(5):155–65.

    PubMed  PubMed Central  Google Scholar 

  137. CDC. Antibiotic resistance threats in the United States. Atlanta: US Department of Health and Human Services; 2019.

    Google Scholar 

  138. Rammelkamp CH. Prevention of rheumatic fever and bacterial endocarditis through control of streptococcal infections. Circulation. 1957;15(1):154–8.

    Article  Google Scholar 

  139. Mortimer EA, Rammelkamp CH. Prophylaxis of rheumatic fever. Circulation. 1956;14(6):1144–52.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Oral and Maxillofacial Surgery, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA

    Steven Halepas

  2. College of Dental Medicine, Columbia University, New York, NY, USA

    Brian Quinn

  3. Division of Infectious Diseases, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA

    Benjamin A. Miko

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  1. Steven Halepas
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  2. Brian Quinn
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  3. Benjamin A. Miko
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Correspondence to Steven Halepas .

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Editors and Affiliations

  1. Quinnipiac University, Frank H Netter MD School of Medicine, North Haven, CT, USA

    Christine E. Niekrash

  2. Division of Oral and Maxillofacial Surgery, University of Connecticut, Farmington, CT, USA

    Elie M. Ferneini

  3. Surgery, Consultant in Oral and Maxillofacial, Carmel, IN, USA

    Michael T. Goupil

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Halepas, S., Quinn, B., Miko, B.A. (2023). Prophylactic Antibiotics. In: Niekrash, C.E., Ferneini, E.M., Goupil, M.T. (eds) Dental Science for the Medical Professional. Springer, Cham. https://doi.org/10.1007/978-3-031-38567-4_15

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