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Keratolimbal Grafts: Outcomes, Innovations and Alternatives

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Modern Keratoplasty

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Limbal epithelial stem cell deficiency is one of the most difficult histopathological causes of corneal opacity and keratoplasty failure. Its implication in the medical and surgical treatment of several corneal diseases has been widely described, but its treatment and clinical results have variable success rates. Several surgical techniques have been proposed in the past century, being limbal autografts from the fellow healthy eye, the one with the most long-term survival rate. The classification of the ocular surface reconstructive techniques is nowadays well defined, and the tissue options and donor sources have been widely described by researchers. Recent advances like Simple limbal epithelial transplantation (SLET) are providing new promising results, waiting until the research in ex vivo expansion and transplantation of isolated limbal stem cells becomes available to the general corneal surgeon.

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Author information

Authors and Affiliations

  1. Centro de Oftalmologia Barraquer, Barcelona, Spain

    Rafael I. Barraquer & Juan Alvarez de Toledo

  2. International University of Catalonia, Barcelona, Spain

    Rafael I. Barraquer

  3. Institut Universitari Barraquer, Univestitat Autònoma de Barcelona, Barcelona, Spain

    Rafael I. Barraquer & Juan Alvarez de Toledo

Authors
  1. Rafael I. Barraquer
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  2. Juan Alvarez de Toledo
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Editor information

Editors and Affiliations

  1. Vissum Miranza, Miguel Hernández University, Alicante, Spain

    Jorge L. Alió

  2. Vissum-Instituto Oftalmologico de Alica, Miguel Hernandez University, Alicante, Alicante, Spain

    Jorge L. Alió del Barrio

Electronic Supplementary Materials

Limbal autograft in a case of a chemical burn (MP4 345158 kb)

Limbal allografts harvesting techniques and combined penetrating keratoplasty (MP4 282295 kb)

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Barraquer, R.I., de Toledo, J.A. (2023). Keratolimbal Grafts: Outcomes, Innovations and Alternatives. In: Alió, J.L., del Barrio, J.L.A. (eds) Modern Keratoplasty. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-031-32408-6_12

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  • DOI: https://doi.org/10.1007/978-3-031-32408-6_12

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  • Online ISBN: 978-3-031-32408-6

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