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Endolysosomal Voltage-Dependent Cation Channels

  • Book
  • © 2023

Overview

Editors:
  1. Christian Wahl-Schott

    1. Institute for Cardiovascular Physiology and Pathophysiology, LMU, Planegg-Martinsried, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Martin Biel

    1. Department Pharmazie der LMU, Pharmakologie für Naturwissenschaften, München, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Discusses high resolution structures of endolysosomal ion channels that became available over the last few years
  • Presents studies involving genetic mouse models that are utilized to derive in vivo function of these channels
  • Highlights functional interaction between endolysosomal membrane proteins and membrane proteins of the ER

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 278)

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About this book

This book covers the molecular structures and the cellular and in vivo function of endosomes and lysosomes, i.e. intracellular vesicles which are involved in many cellular processes such as endocytosis, intracellular trafficking, degradation of material from inside (e.g. autophagy) and outside the cell as well as exocytosis. Membranes of endolysosomal organelles contain an amazing number and diversity of ion channels. These ion channels are the topic of the present book that focusses on describing the structure, the biophysical properties, physiological functions of endolysosomal ion channels at the molecular, cellular and in vivo level. 



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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
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  2. Physiological Functions of Endolysosomal Cation Channels

    1. Front Matter

      Pages 1-1
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    2. NAADP-Mediated Ca2+ Signalling

      • Antony Galione, Lianne C. Davis, Lora L. Martucci, Anthony J. Morgan
      Pages 3-34

    3. NAADP-Dependent TPC Current

      • Qiaochu Wang, Michael X. Zhu
      Pages 35-56

    4. NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axis

      • Andreas H. Guse
      Pages 57-70

    5. TPC Functions in the Immune System

      • Philip Steiner, Elisabeth Arlt, Ingrid Boekhoff, Thomas Gudermann, Susanna Zierler
      Pages 71-92

    6. Lysosomal Ion Channels and Lysosome–Organelle Interactions

      • Weijie Cai, Ping Li, Mingxue Gu, Haoxing Xu
      Pages 93-108

    7. TRPML1 and TFEB, an Intimate Affair

      • Diego Luis Medina
      Pages 109-126

    8. Lysosomal Potassium Channels

      • Peng Huang, Mengnan Xu, Yi Wu, Alia Kazim Rizvi Syeda, Xian-Ping Dong
      Pages 127-152

  3. Structure and Composition of TPC and TRPML Channels

    1. Front Matter

      Pages 153-153
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    2. Structure and Function of Plant and Mammalian TPC Channels

      • Ji She, Jiangtao Guo, Youxing Jiang
      Pages 155-180

    3. A Structural Overview of TRPML1 and the TRPML Family

      • Michael Fine, Xiaochun Li
      Pages 181-198

    4. Endo-Lysosomal Two-Pore Channels and Their Protein Partners

      • Sandip Patel, Spyros Zissimopoulos, Jonathan S. Marchant
      Pages 199-214

  4. Tools and Methods to Characterize Endolysosomal Cation Channels

    1. Front Matter

      Pages 215-215
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    2. Electrophysiological Techniques on the Study of Endolysosomal Ion Channels

      • Cheng-Chang Chen
      Pages 217-233

    3. The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels

      • P. Dietrich, A. Gradogna, A. Carpaneto
      Pages 235-247

    4. Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels

      • Susanne Rautenberg, Marco Keller, Charlotte Leser, Cheng-Chang Chen, Franz Bracher, Christian Grimm
      Pages 249-276

    5. Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging

      • Christian Wahl-Schott, Marc Freichel, Konstantin Hennis, Koenraad Philippaert, Roger Ottenheijm, Volodymyr Tsvilovskyy et al.
      Pages 277-304
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Editors and Affiliations

  • Institute for Cardiovascular Physiology and Pathophysiology, LMU, Planegg-Martinsried, Germany

    Christian Wahl-Schott

  • Department Pharmazie der LMU, Pharmakologie für Naturwissenschaften, München, Germany

    Martin Biel

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