Abstract
Lysosomes are acidic membrane-bound organelles that use hydrolytic enzymes to break down material through pathways such as endocytosis, phagocytosis, mitophagy, and autophagy. To function properly, intralysosomal environments are strictly controlled by a set of integral membrane proteins such as ion channels and transporters. Potassium ion (K+) channels are a large and diverse family of membrane proteins that control K+ flux across both the plasma membrane and intracellular membranes. In the plasma membrane, they are essential in both excitable and non-excitable cells for the control of membrane potential and cell signaling. However, our understanding of intracellular K+ channels is very limited. In this review, we summarize the recent development in studies of K+ channels in the lysosome. We focus on their characterization, potential roles in maintaining lysosomal membrane potential and lysosomal function, and pathological implications.
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Acknowledgements
This work was supported by Canadian Institute of Health Research (CIHR) grant (PJT-156102) to X.P.D. and Shanghai Municipal Health Commission grant (201740161) to P.H. We are grateful to Dr. Dejian Ren for his thoughtful and constructive comments and to other members of the Dong laboratory and the Huang laboratory for their encouragement and helpful criticism.
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Huang, P., Xu, M., Wu, Y., Rizvi Syeda, A.K., Dong, XP. (2022). Lysosomal Potassium Channels. In: Wahl-Schott, C., Biel, M. (eds) Endolysosomal Voltage-Dependent Cation Channels. Handbook of Experimental Pharmacology, vol 278. Springer, Cham. https://doi.org/10.1007/164_2022_600
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