Abstract
Preimplantation genetic testing of aneuploidies of oocytes and embryos in vitro prior to implantation refers to the biopsy of polar bodies, blastomeres or trophoblast cells. In cases not dealing with hereditary diseases, the indications are controversial, like to increase the chance of pregnancy and reduce the risk of miscarriage, multiples, malformation and pointless sterility treatments and when dealing with advanced maternal age, repeated implantation failure, repeated miscarriage and severe male factor. Ethics should be observed when designing studies in this field. Following the introduction of blastocyst biopsy and comprehensive chromosome screening, all RCTs have found some positive effect. The majority view suggests that it works, accompanied by an increasing global use. It should be done with strict indications, taking into account stochastics and the will of the patients.
This chapter is a newly edited, updated, partly shortened, partly extended textbook version of a journal article of the author [1].
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Acknowledgements
I thank my wife and clinical partner Dr. med. Monica Tobler, specialist in reproductive medicine, for many clinical and scientific discussions and the critical review of this chapter.
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Because this investigation analysed theories and the literature and because new patient examinations were not conducted, ethical approval was not required.
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This study was funded by gyn-medicum, Center for Reproductive Medicine, Goettingen, Germany.
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Schmutzler, A.G. (2023). PGT-A also Known as PGS: The Indications. In: Schenker, J.G., Birkhaeuser, M.H., Genazzani, A.R., Mettler, L., Sciarra, J.J. (eds) Hot Topics in Human Reproduction. Reproductive Medicine for Clinicians, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-031-24903-7_15
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