Functional Anatomy of the Cerebellum

Sugihara, Izumi; Luo, Yuanjun; Owusu-Mensah, Richard Nana Abankwah

doi:10.1007/978-3-031-24345-5_1

Izumi Sugihara ORCID: orcid.org/0000-0002-4598-9882^6,7,
Yuanjun Luo⁶ &
Richard Nana Abankwah Owusu-Mensah⁶

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

This chapter revises the neuronal connections and their functional consequences in the mammalian cerebellum based on a new understating of its basic comparative and circuit-level anatomy. The transverse lobular structure and the longitudinally striped arrangement are both essential in understanding the functional organization of the cerebellum. Cerebellar neuronal circuitry has been revealed at the level of single axons. The intricate distribution pattern of zebrin-positive and zebrin-negative Purkinje cells represents the longitudinally striped organization, which is linked to the topographic axonal projection patterns of climbing fibers and Purkinje cells. On the contrary, mossy fibers show distinct axonal projection patterns more or less related to lobules. The cerebellar outputs from different parts of the cerebellar nuclei project to the cerebellar-recipient thalamic nuclei and other targets to be involved in motor and non-motor functions. Tentatively, the cerebellar cortex has some nine divisions of different functional localization related to the region-specific axonal projection patterns.

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The authors have no competing interests to declare.

Acknowledgments

This chapter was supported by Grant-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science (19K06919 and 21F21107 to I.S., and 19H21208 and 20K15911 to Y.L.). L.Y. is a recipient of the JSPS Postdoctoral Fellowship for Overseas Researchers. O.M.R.N.A. is a recipient of the MEXT Scholarship for Overseas Students.

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Department of Systems Neurophysiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
Izumi Sugihara, Yuanjun Luo & Richard Nana Abankwah Owusu-Mensah
Center for Brain Integration Research, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
Izumi Sugihara

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Richard Nana Abankwah Owusu-Mensah
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Professor of Neurology, Shuang Ho Hospital, Taipei Medical University, Taipei, (Republic of China), Taiwan
Bing-wen Soong
Professor of Neuroanatomy, University of Mons and CHU-Charleroi, Charleroi, Belgium
Mario Manto
Paris Brain Institute, (Institut du Cerveau – ICM), CNRS INSERM, Sorbonne Université, APHP, Paris, France
Alexis Brice
Department of Neurology, Spencer Fox Eccles School of Medicine University of Utah, Salt Lake City, UT, USA
Stefan M. Pulst

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Sugihara, I., Luo, Y., Owusu-Mensah, R.N.A. (2023). Functional Anatomy of the Cerebellum. In: Soong, Bw., Manto, M., Brice, A., Pulst, S.M. (eds) Trials for Cerebellar Ataxias. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-031-24345-5_1

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