Abstract
The deep cerebellar nuclei (DCN) are critical in defining the output of the cerebellum. The DCN are positioned at the base of cerebellum where they receive primarily GABAergic inhibitory input from Purkinje cells of cerebellar cortex. DCN cells exhibit a form of rebound membrane depolarization following a hyperpolarization that gives rise to a rebound spike burst. Intracellular recordings and calcium imaging have established roles for virtually all classes of calcium channels in the rebound response, with additional roles for sodium, HCN, and potassium channels. To determine the encoding properties of rebound depolarization in DCN cells, physiological patterns of Purkinje cell firing collected in vivo in response to whisker stimulation have been used to activate Purkinje cell axon tracts in cerebellar slices maintained in vitro. These tests reveal unexpected parameters of afferent spike input from Purkinje cells that are important to driving the rebound depolarizations in DCN cells, and thus the final output from cerebellum.
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Dykstra, S., Turner, R.W. (2023). Rebound Depolarizations. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_41
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DOI: https://doi.org/10.1007/978-3-031-15070-8_41
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