Abstract
The existence of neuropeptides in the central nervous system has been known for over 50 years with the initial studies being conducted in the early 1970s. At present, a total of 33 neuropeptides have been identified in the cerebellum based on the use of different experimental techniques including immunocytochemistry, in situ hybridization, and gene studies. Indirect evidence for the presence of some neuropeptides has been based on studies that identify the presence of their G-protein coupled receptors. Although 33 cerebellar peptides have been identified, relatively little is conclusively known about the modulatory role of the vast majority of these peptides on cerebellar circuits. Further, the function of peptides produced by cerebellar neurons such as Purkinje cells, Golgi cells, or Lugaro cells is poorly if at all defined. Questions need to be addressed as to the role(s) of neuropeptides in modulating the output of the cerebellum, as carried by the axons of cerebellar nuclear neurons. Future research should focus on determining the mechanism of action of these peptides in modulating neuronal activity including defining transduction pathways activated following the binding of the peptide to its receptor. To truly understand the cerebellar function, it is essential to address the effect of the numerous peptides present within cerebellar circuits and the role they play in modulating neuronal activity in the cerebellum.
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Bishop, G.A., King, J.S. (2023). Neuropeptides in the Cerebellum. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_36
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