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Polymeric Micelles for Targeted Drug Delivery Systems

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Pharmaceutical Nanobiotechnology for Targeted Therapy

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

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Abstract

Polymeric micelles exhibit several features that favor their use for drug delivery applications. Although micellar structures have been studied for about 100 years, they are still considered peculiar objects of physicochemical research.

Micelles are nanosized colloidal particles with a hydrophobic inner part (core) and a hydrophilic surface (shell). Drugs and contrast agents can either be embedded in the lipid core of a micelle or covalently bind to its surface. Bifunctional polymeric micelles have been described that are used for simultaneous drug delivery and visualization of damaged tissue. The most important advantage of polymeric micelles is their ability to solubilize poorly water-soluble or hydrophobic drugs within their core, thus enhancing their bioavailability. Based on the type of intermolecular force driving micelle formation, block copolymer micelles can be divided into several categories, including hydrophobically assembled amphiphilic micelles, polyion complex micelles, and micelles stemming from metal complexation. Micelles are advantageous as nanocarriers for drug delivery and treatments owing to their excellent physicochemical properties, drug loading and release capacities, facile preparation methods, biocompatibility, and tumor targetability.

The current line of research in this area is to generate heterogeneous polymeric nanostructures with controlled composition, hydrophilic-hydrophobic balance, and properties. This chapter will consider the existing approaches to preparing polymer micelles for drug delivery applications, the complexity of working with them, and the prospects for their use in therapy.

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Abbreviations

ATP:

Adenosine triphosphate

AuNPs:

Gold nanoparticles

CDs:

Cyclodextrins

CMC:

Critical micelle concentration

DDS:

Drug delivery system

DOX:

Doxorubicin

PBLG:

Poly(γ-benzyl L-glutamate)

PEG:

Polyethylene glycol

PEG–PLA:

Polyethylene glycol–polylactide

RES:

Reticuloendothelial system

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Acknowledgments

This work was supported by the Russian Science Foundation [Projects Nos. 22-24-00417 (O. I. Guliy), and 19-14-00077-II (S. A. Staroverov, A. S. Fomin, L. A. Dykman)].

Conflict of Interest

There are no conflicts of interests in this chapter.

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Authors and Affiliations

  1. Institute of Biochemistry and Physiology of Plants and Microorganisms – Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia

    Olga I. Guliy, Alexander S. Fomin, Sergey A. Staroverov & Lev A. Dykman

  2. Saratov State Vavilov Agrarian University, Saratov, Russia

    Elena G. Zhnichkova, Sergey V. Kozlov & Sergey A. Staroverov

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  1. Olga I. Guliy
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  2. Alexander S. Fomin
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  3. Elena G. Zhnichkova
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  4. Sergey V. Kozlov
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  5. Sergey A. Staroverov
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  6. Lev A. Dykman
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Editors and Affiliations

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran

    Hamed Barabadi

  2. Stanford Cardiovascular Institute & Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Ebrahim Mostafavi

  3. AMR and Nanotherapeutics Laboratory, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India

    Muthupandian Saravanan

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Guliy, O.I., Fomin, A.S., Zhnichkova, E.G., Kozlov, S.V., Staroverov, S.A., Dykman, L.A. (2022). Polymeric Micelles for Targeted Drug Delivery Systems. In: Barabadi, H., Mostafavi, E., Saravanan, M. (eds) Pharmaceutical Nanobiotechnology for Targeted Therapy. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-031-12658-1_18

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