Abstract
Oxidative stress is caused by an imbalance between the overproduction of free radicals and the radical-scavenging anti-oxidative defense system, which results in the accumulation of detrimental reactive oxygen and nitrogen species (ROS/RNS). Seabuckthorn (Hippophae rhamnoides L.) is a precious plant resource that has been reported useful in foods, nutraceuticals, cosmetics, and drugs for a long time. The medicinal value of seabuckthorn is attracting considerable attention mainly for its antioxidant properties. However, there is no systematic literature review focused on the antioxidant capacity and underlying mechanisms of the seabuckthorn extracts. This review summarizes the antioxidant property of the leaf, berry, and oil extracts of seabuckthorn. We also pay much attention to the anti-oxidative properties of the polyphenols, flavonoids, polysaccharides, and other fractions in seabuckthorn extracts. It is noteworthy that the underlying mechanisms of the antioxidant activity of seabuckthorn have been discussed as follows: modulating the NRf-2/ARE antioxidant system, inhibiting the MAPK, NF-κB, STAT3 signaling pathway, suppressing the apoptotic signaling pathway, modulating the metabolic pathway, and impacting the gut microbiota. Major challenges related to the uncertainty problems in the research on seabuckthorn and the key research directions are suggested in this review.
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Acknowledgements
This work was partly supported by grants from the program for Yong Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region (No. NJYT-19-A14) and Inner Mongolia Natural Science foundation (2019MS03019, 2020MS08055, 2020MS08033).
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Zhong, M., Zhao, S., Xie, J., Wang, Y. (2022). Molecular and Cellular Mechanisms of the Anti-oxidative Activity of Seabuckthorn (Hippophae rhamnoides L.). In: Sharma, P.C. (eds) The Seabuckthorn Genome. Compendium of Plant Genomes. Springer, Cham. https://doi.org/10.1007/978-3-031-11276-8_15
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