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Characteristics of Sleep in Critically Ill Patients: Part II: Circadian Rhythm Disruption

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Sleep in Critical Illness

Abstract

Circadian rhythms are ubiquitous in organisms, tuning internal physiology to external conditions and allowing anticipation of environmental daily changes to confer advantage. To synchronize master and peripheral clocks with the environment, organisms entrain their rhythms to external cues. In intensive care units (ICUs), these external cues are mistimed or weak, leading to the desynchronization of patients’ circadian rhythms. This nontherapeutic environment may impair recovery from critical illness. The effects of critical illness itself on circadian rhythms are complex, and it is not known which “dysrhythm” are adaptive and which are harmful and thus represent targets for intervention. In this chapter, we review the basis of circadian rhythms, the circadian disrupters found in ICUs, and the changes in circadian rhythms in critically ill patients.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Iowa, Iowa City, IA, USA

    Marie-Anne Melone

  2. Departments of Internal Medicine and Neurology, University of Iowa, Iowa City, IA, USA

    Brian K. Gehlbach

  3. Department of Pulmonary, Thoracic Oncology and Respiratory Intensive Care, Rouen University Hospital, Rouen, France

    Marie-Anne Melone

Authors
  1. Marie-Anne Melone
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  2. Brian K. Gehlbach
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Correspondence to Brian K. Gehlbach .

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  1. Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Gerald L. Weinhouse

  2. Bouve College of Health Sciences, Northeastern University and Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    John W. Devlin

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Melone, MA., Gehlbach, B.K. (2022). Characteristics of Sleep in Critically Ill Patients: Part II: Circadian Rhythm Disruption. In: Weinhouse, G.L., Devlin, J.W. (eds) Sleep in Critical Illness. Springer, Cham. https://doi.org/10.1007/978-3-031-06447-0_2

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  • DOI: https://doi.org/10.1007/978-3-031-06447-0_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-06446-3

  • Online ISBN: 978-3-031-06447-0

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